Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study

S. Janssen*, K. Osbak, R. Holman, S. Hermans, A. Moekotte, M. Knap, E. Rossatanga, M. Massinga-Loembe, A. Alabi, A. Adegnika, C. Meenken, M. van Vugt, P. G. Kremsner, G. Meintjes, T. van der Poll, M. P. Grobusch

*Corresponding author for this work

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There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in five. All IRIS cases were mucocutaneous manifestations. There were no cases of tuberculosis (TB) IRIS, but active TB (n = 20) was associated with developing other forms of IRIS (p = 0.02). Six patients died. The incidence of IRIS is low in Gabon, with mild, mucocutaneous manifestations.

Original languageEnglish
Pages (from-to)669-676
Number of pages8
Issue number5
Publication statusPublished - 1 Oct 2017

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