Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study

S. Janssen; K. Osbak; R. Holman; S. Hermans; A. Moekotte; M. Knap; E. Rossatanga; M. Massinga-Loembe; A. Alabi; A. Adegnika; C. Meenken; M. van Vugt; P. G. Kremsner; G. Meintjes; T. van der Poll; M. P. Grobusch

doi:10.1007/s15010-017-1000-9

Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study

S. Janssen^*, K. Osbak, R. Holman, S. Hermans, A. Moekotte, M. Knap, E. Rossatanga, M. Massinga-Loembe, A. Alabi, A. Adegnika, C. Meenken, M. van Vugt, P. G. Kremsner, G. Meintjes, T. van der Poll, M. P. Grobusch

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in five. All IRIS cases were mucocutaneous manifestations. There were no cases of tuberculosis (TB) IRIS, but active TB (n = 20) was associated with developing other forms of IRIS (p = 0.02). Six patients died. The incidence of IRIS is low in Gabon, with mild, mucocutaneous manifestations.

Original language	English
Pages (from-to)	669-676
Number of pages	8
Journal	Infection
Volume	45
Issue number	5
DOIs	https://doi.org/10.1007/s15010-017-1000-9
Publication status	Published - 1 Oct 2017

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Janssen, S., Osbak, K., Holman, R., Hermans, S., Moekotte, A., Knap, M., Rossatanga, E., Massinga-Loembe, M., Alabi, A., Adegnika, A., Meenken, C., van Vugt, M., Kremsner, P. G., Meintjes, G., van der Poll, T., & Grobusch, M. P. (2017). Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study. Infection, 45(5), 669-676. https://doi.org/10.1007/s15010-017-1000-9

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title = "Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study",

abstract = "There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in five. All IRIS cases were mucocutaneous manifestations. There were no cases of tuberculosis (TB) IRIS, but active TB (n = 20) was associated with developing other forms of IRIS (p = 0.02). Six patients died. The incidence of IRIS is low in Gabon, with mild, mucocutaneous manifestations.",

keywords = "AIDS, HIV, Opportunistic infections, Tuberculosis",

author = "S. Janssen and K. Osbak and R. Holman and S. Hermans and A. Moekotte and M. Knap and E. Rossatanga and M. Massinga-Loembe and A. Alabi and A. Adegnika and C. Meenken and {van Vugt}, M. and Kremsner, {P. G.} and G. Meintjes and {van der Poll}, T. and Grobusch, {M. P.}",

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Janssen, S, Osbak, K, Holman, R, Hermans, S, Moekotte, A, Knap, M, Rossatanga, E, Massinga-Loembe, M, Alabi, A, Adegnika, A, Meenken, C, van Vugt, M, Kremsner, PG, Meintjes, G, van der Poll, T & Grobusch, MP 2017, 'Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study', Infection, vol. 45, no. 5, pp. 669-676. https://doi.org/10.1007/s15010-017-1000-9

TY - JOUR

T1 - Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon

T2 - a prospective cohort study

AU - Janssen, S.

AU - Osbak, K.

AU - Holman, R.

AU - Hermans, S.

AU - Moekotte, A.

AU - Knap, M.

AU - Rossatanga, E.

AU - Massinga-Loembe, M.

AU - Alabi, A.

AU - Adegnika, A.

AU - Meenken, C.

AU - van Vugt, M.

AU - Kremsner, P. G.

AU - Meintjes, G.

AU - van der Poll, T.

AU - Grobusch, M. P.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in five. All IRIS cases were mucocutaneous manifestations. There were no cases of tuberculosis (TB) IRIS, but active TB (n = 20) was associated with developing other forms of IRIS (p = 0.02). Six patients died. The incidence of IRIS is low in Gabon, with mild, mucocutaneous manifestations.

AB - There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in five. All IRIS cases were mucocutaneous manifestations. There were no cases of tuberculosis (TB) IRIS, but active TB (n = 20) was associated with developing other forms of IRIS (p = 0.02). Six patients died. The incidence of IRIS is low in Gabon, with mild, mucocutaneous manifestations.

KW - AIDS

KW - HIV

KW - Opportunistic infections

KW - Tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=85016100290&partnerID=8YFLogxK

U2 - 10.1007/s15010-017-1000-9

DO - 10.1007/s15010-017-1000-9

M3 - Article

C2 - 28349491

AN - SCOPUS:85016100290

VL - 45

SP - 669

EP - 676

JO - Infection

JF - Infection

SN - 0300-8126

IS - 5

ER -

Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study

Abstract

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