Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study

Carolien N H Abheiden; Birgit S Blomjous; Sylvia J Kroese; Irene E M Bultink; Ruth D E Fritsch-Stork; A Titia Lely; Marjon A de Boer; Johanna I P de Vries

doi:10.1080/10641955.2016.1217337

Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study

Carolien N H Abheiden, Birgit S Blomjous, Sylvia J Kroese, Irene E M Bultink, Ruth D E Fritsch-Stork, A Titia Lely, Marjon A de Boer, Johanna I P de Vries

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS).

METHODS: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015.

RESULTS: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p < 0.001).

CONCLUSION: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Hypertension in Pregnancy
DOIs	https://doi.org/10.1080/10641955.2016.1217337
Publication status	Published - 6 Sept 2016

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10.1080/10641955.2016.1217337

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Abheiden, C. N. H., Blomjous, B. S., Kroese, S. J., Bultink, I. E. M., Fritsch-Stork, R. D. E., Lely, A. T., de Boer, M. A., & de Vries, J. I. P. (2016). Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study. Hypertension in Pregnancy, 1-8. https://doi.org/10.1080/10641955.2016.1217337

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title = "Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study",

abstract = "OBJECTIVE: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS).METHODS: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015.RESULTS: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p < 0.001).CONCLUSION: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.",

author = "Abheiden, {Carolien N H} and Blomjous, {Birgit S} and Kroese, {Sylvia J} and Bultink, {Irene E M} and Fritsch-Stork, {Ruth D E} and Lely, {A Titia} and {de Boer}, {Marjon A} and {de Vries}, {Johanna I P}",

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Abheiden, CNH, Blomjous, BS, Kroese, SJ, Bultink, IEM, Fritsch-Stork, RDE, Lely, AT, de Boer, MA & de Vries, JIP 2016, 'Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study', Hypertension in Pregnancy, pp. 1-8. https://doi.org/10.1080/10641955.2016.1217337

Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome : A cohort study. / Abheiden, Carolien N H; Blomjous, Birgit S; Kroese, Sylvia J et al.

In: Hypertension in Pregnancy, 06.09.2016, p. 1-8.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome

T2 - A cohort study

AU - Abheiden, Carolien N H

AU - Blomjous, Birgit S

AU - Kroese, Sylvia J

AU - Bultink, Irene E M

AU - Fritsch-Stork, Ruth D E

AU - Lely, A Titia

AU - de Boer, Marjon A

AU - de Vries, Johanna I P

PY - 2016/9/6

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N2 - OBJECTIVE: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS).METHODS: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015.RESULTS: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p < 0.001).CONCLUSION: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.

AB - OBJECTIVE: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS).METHODS: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015.RESULTS: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p < 0.001).CONCLUSION: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.

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