Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study

Carolien N H Abheiden, Birgit S Blomjous, Sylvia J Kroese, Irene E M Bultink, Ruth D E Fritsch-Stork, A Titia Lely, Marjon A de Boer, Johanna I P de Vries

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Abstract

OBJECTIVE: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS).

METHODS: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015.

RESULTS: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p < 0.001).

CONCLUSION: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalHypertension in Pregnancy
DOIs
Publication statusPublished - 6 Sep 2016

Cite this

@article{c9855cfcf8cc48b4993606c80557d4ac,
title = "Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study",
abstract = "OBJECTIVE: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS).METHODS: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015.RESULTS: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4{\%}, 23.3{\%}, 50{\%}, 18.4{\%}, respectively, p = 0.12) and preterm birth (16.7{\%}, 34.3{\%}, 75{\%}, 36.8{\%}, respectively, p < 0.001).CONCLUSION: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.",
author = "Abheiden, {Carolien N H} and Blomjous, {Birgit S} and Kroese, {Sylvia J} and Bultink, {Irene E M} and Fritsch-Stork, {Ruth D E} and Lely, {A Titia} and {de Boer}, {Marjon A} and {de Vries}, {Johanna I P}",
year = "2016",
month = "9",
day = "6",
doi = "10.1080/10641955.2016.1217337",
language = "English",
pages = "1--8",
journal = "Hypertension in Pregnancy",
issn = "1064-1955",
publisher = "Informa Healthcare",

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TY - JOUR

T1 - Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome

T2 - A cohort study

AU - Abheiden, Carolien N H

AU - Blomjous, Birgit S

AU - Kroese, Sylvia J

AU - Bultink, Irene E M

AU - Fritsch-Stork, Ruth D E

AU - Lely, A Titia

AU - de Boer, Marjon A

AU - de Vries, Johanna I P

PY - 2016/9/6

Y1 - 2016/9/6

N2 - OBJECTIVE: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS).METHODS: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015.RESULTS: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p < 0.001).CONCLUSION: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.

AB - OBJECTIVE: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS).METHODS: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015.RESULTS: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p < 0.001).CONCLUSION: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.

U2 - 10.1080/10641955.2016.1217337

DO - 10.1080/10641955.2016.1217337

M3 - Article

SP - 1

EP - 8

JO - Hypertension in Pregnancy

JF - Hypertension in Pregnancy

SN - 1064-1955

ER -