Low prevalence of (pre) malignant lesions in the breast and high prevalence in the ovary and fallopian tube in women at hereditary high risk of breast and ovarian cancer

Brenda B.J. Hermsen, Paul J. Van Diest, Johannes Berkhof, Fred H. Menko, Johan J.P. Gille, Jurgen M.J. Piek, Sybren Meijer, Henri A.H. Winters, Peter Kenemans, Silvia Von Mensdorff-Pouilly, René H.M. Verheijen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

To analyse the prevalence of (pre) malignant lesions occurring in breast and adnexal tissue at prophylactic surgery in women at hereditary high risk of breast and/or ovarian cancers. Tissue was obtained from 85 women who underwent prophylactic bilateral salpingo-oophorectomy (pBSO) and from 59 women who underwent prophylactic mastectomy (pM). Control tissue samples were obtained from women undergoing breast reduction surgery (N = 99) or adnexal surgery for benign reasons (N = 72). In women with a BRCA1/2 mutation, the prevalence of a (pre) malignant adnexal lesion was 50% (95% CI 26-74) if older than 40 years and 14% (95% CI 0-58) if younger. The prevalences of (pre) malignant breast lesions in women older than 40 years, with and without a BRCA1/2 mutation, were 0% (95% CI 0-16) and 47% (95% CI 21-73), respectively. No association was found between (pre) malignant lesions in breast and adnexal tissue occurring in 28 women who underwent surgery on both organs (R = 0.155, p = 0.432), but the prevalence of lesions was significantly higher in adnexal tissue than in the breast (p = 0.023). Compared to controls, women at hereditary high risk had a higher chance of (pre) malignant lesions in the breast and an even higher chance of such lesions in the adnexal tissue. There was no indication for concomitant presence of such lesions in both organs at the time of prophylactic surgery. The high frequency of (pre) malignant lesions in the adnexal tissue stresses further the importance of pBSO from the age of 40 onwards in women at hereditary high risk.

Original languageEnglish
Pages (from-to)1412-1418
Number of pages7
JournalInternational Journal of Cancer
Volume119
Issue number6
DOIs
Publication statusPublished - 15 Sep 2006

Cite this

Hermsen, Brenda B.J. ; Van Diest, Paul J. ; Berkhof, Johannes ; Menko, Fred H. ; Gille, Johan J.P. ; Piek, Jurgen M.J. ; Meijer, Sybren ; Winters, Henri A.H. ; Kenemans, Peter ; Von Mensdorff-Pouilly, Silvia ; Verheijen, René H.M. / Low prevalence of (pre) malignant lesions in the breast and high prevalence in the ovary and fallopian tube in women at hereditary high risk of breast and ovarian cancer. In: International Journal of Cancer. 2006 ; Vol. 119, No. 6. pp. 1412-1418.
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title = "Low prevalence of (pre) malignant lesions in the breast and high prevalence in the ovary and fallopian tube in women at hereditary high risk of breast and ovarian cancer",
abstract = "To analyse the prevalence of (pre) malignant lesions occurring in breast and adnexal tissue at prophylactic surgery in women at hereditary high risk of breast and/or ovarian cancers. Tissue was obtained from 85 women who underwent prophylactic bilateral salpingo-oophorectomy (pBSO) and from 59 women who underwent prophylactic mastectomy (pM). Control tissue samples were obtained from women undergoing breast reduction surgery (N = 99) or adnexal surgery for benign reasons (N = 72). In women with a BRCA1/2 mutation, the prevalence of a (pre) malignant adnexal lesion was 50{\%} (95{\%} CI 26-74) if older than 40 years and 14{\%} (95{\%} CI 0-58) if younger. The prevalences of (pre) malignant breast lesions in women older than 40 years, with and without a BRCA1/2 mutation, were 0{\%} (95{\%} CI 0-16) and 47{\%} (95{\%} CI 21-73), respectively. No association was found between (pre) malignant lesions in breast and adnexal tissue occurring in 28 women who underwent surgery on both organs (R = 0.155, p = 0.432), but the prevalence of lesions was significantly higher in adnexal tissue than in the breast (p = 0.023). Compared to controls, women at hereditary high risk had a higher chance of (pre) malignant lesions in the breast and an even higher chance of such lesions in the adnexal tissue. There was no indication for concomitant presence of such lesions in both organs at the time of prophylactic surgery. The high frequency of (pre) malignant lesions in the adnexal tissue stresses further the importance of pBSO from the age of 40 onwards in women at hereditary high risk.",
keywords = "BRCA1/2, Breast, Ovary, Premalignant lesions",
author = "Hermsen, {Brenda B.J.} and {Van Diest}, {Paul J.} and Johannes Berkhof and Menko, {Fred H.} and Gille, {Johan J.P.} and Piek, {Jurgen M.J.} and Sybren Meijer and Winters, {Henri A.H.} and Peter Kenemans and {Von Mensdorff-Pouilly}, Silvia and Verheijen, {Ren{\'e} H.M.}",
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language = "English",
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Low prevalence of (pre) malignant lesions in the breast and high prevalence in the ovary and fallopian tube in women at hereditary high risk of breast and ovarian cancer. / Hermsen, Brenda B.J.; Van Diest, Paul J.; Berkhof, Johannes; Menko, Fred H.; Gille, Johan J.P.; Piek, Jurgen M.J.; Meijer, Sybren; Winters, Henri A.H.; Kenemans, Peter; Von Mensdorff-Pouilly, Silvia; Verheijen, René H.M.

In: International Journal of Cancer, Vol. 119, No. 6, 15.09.2006, p. 1412-1418.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Low prevalence of (pre) malignant lesions in the breast and high prevalence in the ovary and fallopian tube in women at hereditary high risk of breast and ovarian cancer

AU - Hermsen, Brenda B.J.

AU - Van Diest, Paul J.

AU - Berkhof, Johannes

AU - Menko, Fred H.

AU - Gille, Johan J.P.

AU - Piek, Jurgen M.J.

AU - Meijer, Sybren

AU - Winters, Henri A.H.

AU - Kenemans, Peter

AU - Von Mensdorff-Pouilly, Silvia

AU - Verheijen, René H.M.

PY - 2006/9/15

Y1 - 2006/9/15

N2 - To analyse the prevalence of (pre) malignant lesions occurring in breast and adnexal tissue at prophylactic surgery in women at hereditary high risk of breast and/or ovarian cancers. Tissue was obtained from 85 women who underwent prophylactic bilateral salpingo-oophorectomy (pBSO) and from 59 women who underwent prophylactic mastectomy (pM). Control tissue samples were obtained from women undergoing breast reduction surgery (N = 99) or adnexal surgery for benign reasons (N = 72). In women with a BRCA1/2 mutation, the prevalence of a (pre) malignant adnexal lesion was 50% (95% CI 26-74) if older than 40 years and 14% (95% CI 0-58) if younger. The prevalences of (pre) malignant breast lesions in women older than 40 years, with and without a BRCA1/2 mutation, were 0% (95% CI 0-16) and 47% (95% CI 21-73), respectively. No association was found between (pre) malignant lesions in breast and adnexal tissue occurring in 28 women who underwent surgery on both organs (R = 0.155, p = 0.432), but the prevalence of lesions was significantly higher in adnexal tissue than in the breast (p = 0.023). Compared to controls, women at hereditary high risk had a higher chance of (pre) malignant lesions in the breast and an even higher chance of such lesions in the adnexal tissue. There was no indication for concomitant presence of such lesions in both organs at the time of prophylactic surgery. The high frequency of (pre) malignant lesions in the adnexal tissue stresses further the importance of pBSO from the age of 40 onwards in women at hereditary high risk.

AB - To analyse the prevalence of (pre) malignant lesions occurring in breast and adnexal tissue at prophylactic surgery in women at hereditary high risk of breast and/or ovarian cancers. Tissue was obtained from 85 women who underwent prophylactic bilateral salpingo-oophorectomy (pBSO) and from 59 women who underwent prophylactic mastectomy (pM). Control tissue samples were obtained from women undergoing breast reduction surgery (N = 99) or adnexal surgery for benign reasons (N = 72). In women with a BRCA1/2 mutation, the prevalence of a (pre) malignant adnexal lesion was 50% (95% CI 26-74) if older than 40 years and 14% (95% CI 0-58) if younger. The prevalences of (pre) malignant breast lesions in women older than 40 years, with and without a BRCA1/2 mutation, were 0% (95% CI 0-16) and 47% (95% CI 21-73), respectively. No association was found between (pre) malignant lesions in breast and adnexal tissue occurring in 28 women who underwent surgery on both organs (R = 0.155, p = 0.432), but the prevalence of lesions was significantly higher in adnexal tissue than in the breast (p = 0.023). Compared to controls, women at hereditary high risk had a higher chance of (pre) malignant lesions in the breast and an even higher chance of such lesions in the adnexal tissue. There was no indication for concomitant presence of such lesions in both organs at the time of prophylactic surgery. The high frequency of (pre) malignant lesions in the adnexal tissue stresses further the importance of pBSO from the age of 40 onwards in women at hereditary high risk.

KW - BRCA1/2

KW - Breast

KW - Ovary

KW - Premalignant lesions

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U2 - 10.1002/ijc.21988

DO - 10.1002/ijc.21988

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JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

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