TY - JOUR
T1 - Lower cerebral blood flow is associated with impairment in multiple cognitive domains in Alzheimer's disease
AU - Leeuwis, Anna E.
AU - Benedictus, Marije R.
AU - Kuijer, Joost P.A.
AU - Binnewijzend, Maja A.A.
AU - Hooghiemstra, Astrid M.
AU - Verfaillie, Sander C.J.
AU - Koene, Teddy
AU - Scheltens, Philip
AU - Barkhof, Frederik
AU - Prins, Niels D.
AU - van der Flier, Wiesje M.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Introduction We examined the association between decreased cerebral blood flow (CBF) and cognitive impairment in Alzheimer's disease (AD), mild cognitive impairment (MCI), and subjective cognitive decline (SCD). Methods We included 161 AD, 95 MCI, and 143 SCD patients from the Amsterdam Dementia Cohort. We used 3-T pseudo-continuous arterial spin labeling to estimate whole-brain and regional partial volume–corrected CBF. Neuropsychological tests covered global cognition and five cognitive domains. Associations were investigated using linear regression analyses. Results In the whole sample, reduced overall and regional CBF was associated with impairment in all cognitive domains. We found significant interactions between diagnosis and CBF for language and between diagnosis and parietal CBF for global cognition and executive functioning. Stratification showed that decreased CBF was associated with worse performance in AD patients but not in MCI or SCD. Discussion Our results suggest that CBF may have potential as a functional marker of disease severity.
AB - Introduction We examined the association between decreased cerebral blood flow (CBF) and cognitive impairment in Alzheimer's disease (AD), mild cognitive impairment (MCI), and subjective cognitive decline (SCD). Methods We included 161 AD, 95 MCI, and 143 SCD patients from the Amsterdam Dementia Cohort. We used 3-T pseudo-continuous arterial spin labeling to estimate whole-brain and regional partial volume–corrected CBF. Neuropsychological tests covered global cognition and five cognitive domains. Associations were investigated using linear regression analyses. Results In the whole sample, reduced overall and regional CBF was associated with impairment in all cognitive domains. We found significant interactions between diagnosis and CBF for language and between diagnosis and parietal CBF for global cognition and executive functioning. Stratification showed that decreased CBF was associated with worse performance in AD patients but not in MCI or SCD. Discussion Our results suggest that CBF may have potential as a functional marker of disease severity.
KW - Alzheimer's disease
KW - Arterial spin labeling
KW - Brain perfusion
KW - Cognition
KW - Dementia
UR - http://www.scopus.com/inward/record.url?scp=85005950971&partnerID=8YFLogxK
U2 - 10.1016/j.jalz.2016.08.013
DO - 10.1016/j.jalz.2016.08.013
M3 - Article
C2 - 27693109
AN - SCOPUS:85005950971
VL - 13
SP - 531
EP - 540
JO - Alzheimers & Dementia
JF - Alzheimers & Dementia
SN - 1552-5260
IS - 5
ER -