Macronodular adrenocortical hyperplasia in a postmenopausal woman

G. S. Mijnhout, S. A. Danner, F. R W van de Goot, E. W C M van Dam

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

This case report describes the diagnosis of Cushing's syndrome due to macronodular adrenal hyperplasia in an elderly woman who presented with fatigue, muscle weakness and oedema, and recent excessive bruising. Long-standing disease and comorbidity precluded adrenalectomy. Despite treatment with metyrapone and diuretics, the patient died after two months hospitalisation. Postmortal examination revealed overexpression of luteinising hormone (LH) receptors in the adrenal glands, suggesting that the postmenopausal rise in LH may have a role in adrenal hyperplasia and hypercortisolism.

Original languageEnglish
Pages (from-to)454-455
Number of pages2
JournalNetherlands Journal of Medicine
Volume62
Issue number11
Publication statusPublished - 1 Dec 2004

Cite this

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Macronodular adrenocortical hyperplasia in a postmenopausal woman. / Mijnhout, G. S.; Danner, S. A.; van de Goot, F. R W; van Dam, E. W C M.

In: Netherlands Journal of Medicine, Vol. 62, No. 11, 01.12.2004, p. 454-455.

Research output: Contribution to journalArticleAcademicpeer-review

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N2 - This case report describes the diagnosis of Cushing's syndrome due to macronodular adrenal hyperplasia in an elderly woman who presented with fatigue, muscle weakness and oedema, and recent excessive bruising. Long-standing disease and comorbidity precluded adrenalectomy. Despite treatment with metyrapone and diuretics, the patient died after two months hospitalisation. Postmortal examination revealed overexpression of luteinising hormone (LH) receptors in the adrenal glands, suggesting that the postmenopausal rise in LH may have a role in adrenal hyperplasia and hypercortisolism.

AB - This case report describes the diagnosis of Cushing's syndrome due to macronodular adrenal hyperplasia in an elderly woman who presented with fatigue, muscle weakness and oedema, and recent excessive bruising. Long-standing disease and comorbidity precluded adrenalectomy. Despite treatment with metyrapone and diuretics, the patient died after two months hospitalisation. Postmortal examination revealed overexpression of luteinising hormone (LH) receptors in the adrenal glands, suggesting that the postmenopausal rise in LH may have a role in adrenal hyperplasia and hypercortisolism.

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