Macrophage Immunometabolism: Where Are We (Going)?

Jan Van den Bossche, Luke A O'Neill, Deepthi Menon

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

A growing number of findings highlight the crucial role of metabolic reprogramming in macrophage activation. Metabolic pathways are closely interconnected and recent literature demonstrates the need for glucose metabolism in anti-inflammatory as well as inflammatory macrophages. Moreover, fatty acid oxidation (FAO) not only supports anti-inflammatory responses as described formerly but also drives inflammasome activation in inflammatory macrophages. Hence, defining glycolysis as proinflammatory and FAO as anti-inflammatory may be an oversimplification. Here we review how the rapid growth of the immunometabolism field has improved our understanding of macrophage activation and at the same time has led to an increase in the appearance of contradictory observations. To conclude we discuss current challenges in immunometabolism and present crucial areas for future research.

Original languageEnglish
Pages (from-to)395-406
Number of pages12
JournalTrends in Immunology
Volume38
Issue number6
DOIs
Publication statusPublished - Jun 2017

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