Abstract
Purpose: To study the use of image registration in the analysis of multiple sclerosis (MS) lesion volume and compare this with repositioning error and observer-based variability. Materials and Methods: The normalized mutual information (NMI) algorithm is evaluated in an accuracy study using a phantom, followed by a validation study on magnetic resonance (MR) data of MS patients. Further, using scan-rescan MR data, the effect of registration on MS lesion volume compared with repositioning error and observer based variability is assessed. Results: The registration accuracy was near perfect in the phantom study, while the in vivo validation study demonstrated an accuracy on the order of 0.2-0.3 mm. In the scan-rescan study, quantification accounted for 15.6% of the relative variance, repositioning for 44,4%, and registration for 40,0%. Conclusion: NMI resulted in robust and accurate alignment of MR brain images of MS patients. Its use in the detection of changes in MS using large serial MR imaging (MRI) data warrants future evaluation.
| Original language | English |
|---|---|
| Pages (from-to) | 505-510 |
| Number of pages | 6 |
| Journal | Journal of Magnetic Resonance Imaging |
| Volume | 15 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 13 May 2002 |
Cite this
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Magnetic resonance image registration in multiple sclerosis : Comparison with repositioning error and observer-based variability. / Leng Tan, I.; Van Schijndel, Ronald A.; Van Walderveen, Marianne A.A.; Quist, Marcel; Bos, Reinhard; Pouwels, Petra J.W.; Desmedt, Pol; Adr, Herman J.; Barkhof, Frederik.
In: Journal of Magnetic Resonance Imaging, Vol. 15, No. 5, 13.05.2002, p. 505-510.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Magnetic resonance image registration in multiple sclerosis
T2 - Comparison with repositioning error and observer-based variability
AU - Leng Tan, I.
AU - Van Schijndel, Ronald A.
AU - Van Walderveen, Marianne A.A.
AU - Quist, Marcel
AU - Bos, Reinhard
AU - Pouwels, Petra J.W.
AU - Desmedt, Pol
AU - Adr, Herman J.
AU - Barkhof, Frederik
PY - 2002/5/13
Y1 - 2002/5/13
N2 - Purpose: To study the use of image registration in the analysis of multiple sclerosis (MS) lesion volume and compare this with repositioning error and observer-based variability. Materials and Methods: The normalized mutual information (NMI) algorithm is evaluated in an accuracy study using a phantom, followed by a validation study on magnetic resonance (MR) data of MS patients. Further, using scan-rescan MR data, the effect of registration on MS lesion volume compared with repositioning error and observer based variability is assessed. Results: The registration accuracy was near perfect in the phantom study, while the in vivo validation study demonstrated an accuracy on the order of 0.2-0.3 mm. In the scan-rescan study, quantification accounted for 15.6% of the relative variance, repositioning for 44,4%, and registration for 40,0%. Conclusion: NMI resulted in robust and accurate alignment of MR brain images of MS patients. Its use in the detection of changes in MS using large serial MR imaging (MRI) data warrants future evaluation.
AB - Purpose: To study the use of image registration in the analysis of multiple sclerosis (MS) lesion volume and compare this with repositioning error and observer-based variability. Materials and Methods: The normalized mutual information (NMI) algorithm is evaluated in an accuracy study using a phantom, followed by a validation study on magnetic resonance (MR) data of MS patients. Further, using scan-rescan MR data, the effect of registration on MS lesion volume compared with repositioning error and observer based variability is assessed. Results: The registration accuracy was near perfect in the phantom study, while the in vivo validation study demonstrated an accuracy on the order of 0.2-0.3 mm. In the scan-rescan study, quantification accounted for 15.6% of the relative variance, repositioning for 44,4%, and registration for 40,0%. Conclusion: NMI resulted in robust and accurate alignment of MR brain images of MS patients. Its use in the detection of changes in MS using large serial MR imaging (MRI) data warrants future evaluation.
KW - Image registration
KW - Magnetic resonance imaging
KW - Multiple sclerosis
KW - Mutual information
KW - Repositioning
UR - http://www.scopus.com/inward/record.url?scp=0036238396&partnerID=8YFLogxK
U2 - 10.1002/jmri.10093
DO - 10.1002/jmri.10093
M3 - Article
VL - 15
SP - 505
EP - 510
JO - Journal of magnetic resonance imaging : JMRI
JF - Journal of magnetic resonance imaging : JMRI
SN - 1053-1807
IS - 5
ER -