Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis

James William L. Brown, Azmain Chowdhury, Baris Kanber, Ferran Prados Carrasco, Arman Eshaghi, Carole H. Sudre, Matteo Pardini, Rebecca S. Samson, Steven H. P. van de Pavert, Claudia Gandini Wheeler-Kingshott, Declan T. Chard

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: In relapse-onset multiple sclerosis (MS), tissue abnormality – as assessed with magnetisation transfer ratio (MTR) imaging – is greater in the outer cortical and inner periventricular layers. The cause of this remains unknown but meningeal inflammation has been implicated, particularly lymphoid follicles, which are seen in secondary progressive (SP) but not primary progressive (PP) MS. Cortical and periventricular MTR gradients might, therefore, differ in PPMS and SPMS if these follicles are responsible. Objective: We assessed cortical and periventricular MTR gradients in PPMS, and compared gradients between people with PPMS and SPMS. Methods: Using an optimised processing pipeline, periventricular normal-appearing white matter and cortical grey-matter MTR gradients were compared between 51 healthy controls and 63 people with progressive MS (28 PPMS, 35 SPMS). Results: The periventricular gradient was significantly shallower in healthy controls (0.122 percentage units (pu)/band) compared to PPMS (0.952 pu/band, p < 0.0001) and SPMS (1.360 pu/band, p < 0.0001). The cortical gradient was also significantly shallower in healthy controls (−2.860 pu/band) compared to PPMS (−3.214 pu/band, p = 0.038) and SPMS (−3.328 pu/band, p = 0.016). Conclusion: Abnormal periventricular and cortical MTR gradients occur in both PPMS and SPMS, suggesting comparable underlying pathological processes.
Original languageEnglish
JournalMultiple Sclerosis Journal
DOIs
Publication statusPublished - 2019

Cite this

Brown, James William L. ; Chowdhury, Azmain ; Kanber, Baris ; Prados Carrasco, Ferran ; Eshaghi, Arman ; Sudre, Carole H. ; Pardini, Matteo ; Samson, Rebecca S. ; van de Pavert, Steven H. P. ; Wheeler-Kingshott, Claudia Gandini ; Chard, Declan T. / Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis. In: Multiple Sclerosis Journal. 2019.
@article{bc832a9100c743a6af5c3714b4480176,
title = "Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis",
abstract = "Background: In relapse-onset multiple sclerosis (MS), tissue abnormality – as assessed with magnetisation transfer ratio (MTR) imaging – is greater in the outer cortical and inner periventricular layers. The cause of this remains unknown but meningeal inflammation has been implicated, particularly lymphoid follicles, which are seen in secondary progressive (SP) but not primary progressive (PP) MS. Cortical and periventricular MTR gradients might, therefore, differ in PPMS and SPMS if these follicles are responsible. Objective: We assessed cortical and periventricular MTR gradients in PPMS, and compared gradients between people with PPMS and SPMS. Methods: Using an optimised processing pipeline, periventricular normal-appearing white matter and cortical grey-matter MTR gradients were compared between 51 healthy controls and 63 people with progressive MS (28 PPMS, 35 SPMS). Results: The periventricular gradient was significantly shallower in healthy controls (0.122 percentage units (pu)/band) compared to PPMS (0.952 pu/band, p < 0.0001) and SPMS (1.360 pu/band, p < 0.0001). The cortical gradient was also significantly shallower in healthy controls (−2.860 pu/band) compared to PPMS (−3.214 pu/band, p = 0.038) and SPMS (−3.328 pu/band, p = 0.016). Conclusion: Abnormal periventricular and cortical MTR gradients occur in both PPMS and SPMS, suggesting comparable underlying pathological processes.",
author = "Brown, {James William L.} and Azmain Chowdhury and Baris Kanber and {Prados Carrasco}, Ferran and Arman Eshaghi and Sudre, {Carole H.} and Matteo Pardini and Samson, {Rebecca S.} and {van de Pavert}, {Steven H. P.} and Wheeler-Kingshott, {Claudia Gandini} and Chard, {Declan T.}",
year = "2019",
doi = "10.1177/1352458519841810",
language = "English",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",

}

Brown, JWL, Chowdhury, A, Kanber, B, Prados Carrasco, F, Eshaghi, A, Sudre, CH, Pardini, M, Samson, RS, van de Pavert, SHP, Wheeler-Kingshott, CG & Chard, DT 2019, 'Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis' Multiple Sclerosis Journal. https://doi.org/10.1177/1352458519841810

Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis. / Brown, James William L.; Chowdhury, Azmain; Kanber, Baris; Prados Carrasco, Ferran; Eshaghi, Arman; Sudre, Carole H.; Pardini, Matteo; Samson, Rebecca S.; van de Pavert, Steven H. P.; Wheeler-Kingshott, Claudia Gandini; Chard, Declan T.

In: Multiple Sclerosis Journal, 2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis

AU - Brown, James William L.

AU - Chowdhury, Azmain

AU - Kanber, Baris

AU - Prados Carrasco, Ferran

AU - Eshaghi, Arman

AU - Sudre, Carole H.

AU - Pardini, Matteo

AU - Samson, Rebecca S.

AU - van de Pavert, Steven H. P.

AU - Wheeler-Kingshott, Claudia Gandini

AU - Chard, Declan T.

PY - 2019

Y1 - 2019

N2 - Background: In relapse-onset multiple sclerosis (MS), tissue abnormality – as assessed with magnetisation transfer ratio (MTR) imaging – is greater in the outer cortical and inner periventricular layers. The cause of this remains unknown but meningeal inflammation has been implicated, particularly lymphoid follicles, which are seen in secondary progressive (SP) but not primary progressive (PP) MS. Cortical and periventricular MTR gradients might, therefore, differ in PPMS and SPMS if these follicles are responsible. Objective: We assessed cortical and periventricular MTR gradients in PPMS, and compared gradients between people with PPMS and SPMS. Methods: Using an optimised processing pipeline, periventricular normal-appearing white matter and cortical grey-matter MTR gradients were compared between 51 healthy controls and 63 people with progressive MS (28 PPMS, 35 SPMS). Results: The periventricular gradient was significantly shallower in healthy controls (0.122 percentage units (pu)/band) compared to PPMS (0.952 pu/band, p < 0.0001) and SPMS (1.360 pu/band, p < 0.0001). The cortical gradient was also significantly shallower in healthy controls (−2.860 pu/band) compared to PPMS (−3.214 pu/band, p = 0.038) and SPMS (−3.328 pu/band, p = 0.016). Conclusion: Abnormal periventricular and cortical MTR gradients occur in both PPMS and SPMS, suggesting comparable underlying pathological processes.

AB - Background: In relapse-onset multiple sclerosis (MS), tissue abnormality – as assessed with magnetisation transfer ratio (MTR) imaging – is greater in the outer cortical and inner periventricular layers. The cause of this remains unknown but meningeal inflammation has been implicated, particularly lymphoid follicles, which are seen in secondary progressive (SP) but not primary progressive (PP) MS. Cortical and periventricular MTR gradients might, therefore, differ in PPMS and SPMS if these follicles are responsible. Objective: We assessed cortical and periventricular MTR gradients in PPMS, and compared gradients between people with PPMS and SPMS. Methods: Using an optimised processing pipeline, periventricular normal-appearing white matter and cortical grey-matter MTR gradients were compared between 51 healthy controls and 63 people with progressive MS (28 PPMS, 35 SPMS). Results: The periventricular gradient was significantly shallower in healthy controls (0.122 percentage units (pu)/band) compared to PPMS (0.952 pu/band, p < 0.0001) and SPMS (1.360 pu/band, p < 0.0001). The cortical gradient was also significantly shallower in healthy controls (−2.860 pu/band) compared to PPMS (−3.214 pu/band, p = 0.038) and SPMS (−3.328 pu/band, p = 0.016). Conclusion: Abnormal periventricular and cortical MTR gradients occur in both PPMS and SPMS, suggesting comparable underlying pathological processes.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/30957691

U2 - 10.1177/1352458519841810

DO - 10.1177/1352458519841810

M3 - Article

JO - Multiple Sclerosis

JF - Multiple Sclerosis

SN - 1352-4585

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