Magnetization transfer imaging of gray and white matter in mild cognitive impairment and Alzheimer's disease

A. C.G.M. van Es; W. M. van der Flier; F. Admiraal-Behloul; H. Olofsen; E. L.E.M. Bollen; H. A.M. Middelkoop; A. W.E. Weverling-Rijnsburger; R. G.J. Westendorp; M. A. van Buchem

doi:10.1016/j.neurobiolaging.2005.09.042

Magnetization transfer imaging of gray and white matter in mild cognitive impairment and Alzheimer's disease

A. C.G.M. van Es^*, W. M. van der Flier, F. Admiraal-Behloul, H. Olofsen, E. L.E.M. Bollen, H. A.M. Middelkoop, A. W.E. Weverling-Rijnsburger, R. G.J. Westendorp, M. A. van Buchem

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective: To assess whether structural brain damage as detected by magnetization transfer imaging (MTI) in Alzheimer's disease (AD) and mild cognitive impairment (MCI) is located in the gray matter (GM) and/or the white matter (WM). Methods: Fifty-five AD patients, 19 MCI patients and 43 subjects with normal cognitive function participated in this study. GM and WM segmentations were generated from dual fast spin-echo MR images. These masks were co-registrated to MT images for volumetric MTI-analysis of the GM and WM. Results: AD patients had a lower GM volume than controls. Both MCI and AD patients had more structural brain damage in both GM and WM than subjects with normal cognition. Cerebral lesion load in both GM and WM was associated with the degree of cognitive impairment. Conclusion: Using MTI, structural brain changes that are related to cognitive impairment could be demonstrated in both GM and WM of patients with AD and MCI. These results suggest that cerebral changes are present in GM and WM even before patients are clinically demented.

Original language	English
Pages (from-to)	1757-1762
Number of pages	6
Journal	Neurobiology of Aging
Volume	27
Issue number	12
DOIs	https://doi.org/10.1016/j.neurobiolaging.2005.09.042
Publication status	Published - 1 Dec 2006

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van Es, A. C. G. M., van der Flier, W. M., Admiraal-Behloul, F., Olofsen, H., Bollen, E. L. E. M., Middelkoop, H. A. M., Weverling-Rijnsburger, A. W. E., Westendorp, R. G. J., & van Buchem, M. A. (2006). Magnetization transfer imaging of gray and white matter in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging, 27(12), 1757-1762. https://doi.org/10.1016/j.neurobiolaging.2005.09.042

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title = "Magnetization transfer imaging of gray and white matter in mild cognitive impairment and Alzheimer's disease",

abstract = "Objective: To assess whether structural brain damage as detected by magnetization transfer imaging (MTI) in Alzheimer's disease (AD) and mild cognitive impairment (MCI) is located in the gray matter (GM) and/or the white matter (WM). Methods: Fifty-five AD patients, 19 MCI patients and 43 subjects with normal cognitive function participated in this study. GM and WM segmentations were generated from dual fast spin-echo MR images. These masks were co-registrated to MT images for volumetric MTI-analysis of the GM and WM. Results: AD patients had a lower GM volume than controls. Both MCI and AD patients had more structural brain damage in both GM and WM than subjects with normal cognition. Cerebral lesion load in both GM and WM was associated with the degree of cognitive impairment. Conclusion: Using MTI, structural brain changes that are related to cognitive impairment could be demonstrated in both GM and WM of patients with AD and MCI. These results suggest that cerebral changes are present in GM and WM even before patients are clinically demented.",

keywords = "Alzheimer's disease, Grey matter, Magnetic resonance imaging, Magnetization transfer imaging, Mild cognitive impairment, White matter",

author = "{van Es}, {A. C.G.M.} and {van der Flier}, {W. M.} and F. Admiraal-Behloul and H. Olofsen and Bollen, {E. L.E.M.} and Middelkoop, {H. A.M.} and Weverling-Rijnsburger, {A. W.E.} and Westendorp, {R. G.J.} and {van Buchem}, {M. A.}",

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doi = "10.1016/j.neurobiolaging.2005.09.042",

language = "English",

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journal = "Neurobiology of Aging",

issn = "0197-4580",

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van Es, ACGM, van der Flier, WM, Admiraal-Behloul, F, Olofsen, H, Bollen, ELEM, Middelkoop, HAM, Weverling-Rijnsburger, AWE, Westendorp, RGJ & van Buchem, MA 2006, 'Magnetization transfer imaging of gray and white matter in mild cognitive impairment and Alzheimer's disease', Neurobiology of Aging, vol. 27, no. 12, pp. 1757-1762. https://doi.org/10.1016/j.neurobiolaging.2005.09.042

TY - JOUR

T1 - Magnetization transfer imaging of gray and white matter in mild cognitive impairment and Alzheimer's disease

AU - van Es, A. C.G.M.

AU - van der Flier, W. M.

AU - Admiraal-Behloul, F.

AU - Olofsen, H.

AU - Bollen, E. L.E.M.

AU - Middelkoop, H. A.M.

AU - Weverling-Rijnsburger, A. W.E.

AU - Westendorp, R. G.J.

AU - van Buchem, M. A.

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Objective: To assess whether structural brain damage as detected by magnetization transfer imaging (MTI) in Alzheimer's disease (AD) and mild cognitive impairment (MCI) is located in the gray matter (GM) and/or the white matter (WM). Methods: Fifty-five AD patients, 19 MCI patients and 43 subjects with normal cognitive function participated in this study. GM and WM segmentations were generated from dual fast spin-echo MR images. These masks were co-registrated to MT images for volumetric MTI-analysis of the GM and WM. Results: AD patients had a lower GM volume than controls. Both MCI and AD patients had more structural brain damage in both GM and WM than subjects with normal cognition. Cerebral lesion load in both GM and WM was associated with the degree of cognitive impairment. Conclusion: Using MTI, structural brain changes that are related to cognitive impairment could be demonstrated in both GM and WM of patients with AD and MCI. These results suggest that cerebral changes are present in GM and WM even before patients are clinically demented.

AB - Objective: To assess whether structural brain damage as detected by magnetization transfer imaging (MTI) in Alzheimer's disease (AD) and mild cognitive impairment (MCI) is located in the gray matter (GM) and/or the white matter (WM). Methods: Fifty-five AD patients, 19 MCI patients and 43 subjects with normal cognitive function participated in this study. GM and WM segmentations were generated from dual fast spin-echo MR images. These masks were co-registrated to MT images for volumetric MTI-analysis of the GM and WM. Results: AD patients had a lower GM volume than controls. Both MCI and AD patients had more structural brain damage in both GM and WM than subjects with normal cognition. Cerebral lesion load in both GM and WM was associated with the degree of cognitive impairment. Conclusion: Using MTI, structural brain changes that are related to cognitive impairment could be demonstrated in both GM and WM of patients with AD and MCI. These results suggest that cerebral changes are present in GM and WM even before patients are clinically demented.

KW - Alzheimer's disease

KW - Grey matter

KW - Magnetic resonance imaging

KW - Magnetization transfer imaging

KW - Mild cognitive impairment

KW - White matter

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AN - SCOPUS:33750208615

VL - 27

SP - 1757

EP - 1762

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 12

ER -

Magnetization transfer imaging of gray and white matter in mild cognitive impairment and Alzheimer's disease

Abstract

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