Magnetization transfer ratio measurement in multiple sclerosis normal-appearing brain tissue: Limited differences with controls but relationships with clinical and MR measures of disease

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Abstract

We investigated the magnetization transfer ratio (MTR) of normal-appearing white (NAWM) and grey matter (NAGM) in a relatively large group of multiple sclerosis (MS) patients, and the relations of MTR changes with clinical disability. MTR was measured in 66 MS patients (12 PP, 35 RR, 19 SP) and 23 healthy controls, using a whole-brain 3D-FLASH technique corrected post-hoc for B1-induced variation. Histogram parameters of conservatively selected NAWM and cortical NAGM were analysed using Bonferroni-corrected ANOVA with age as covariate. Additionally, manually outlined regions of interest were analysed using a multilevel method. Lesions had low MTR (mean 22.7 ± 6.9%), but NAWM exhibited limited changes: MTR histogram peak position was 32.8 ± 1.0% in controls and 32.4 ± 0.9% in MS patients, with a significant decrease compared to controls only in SPMS patients (31.9 ± 1.1%, p=0.045). Cortical NAGM histograms did not differ significantly between patients and controls. In SPMS, regional mean MTR was significantly decreased in corpus callosum and hippocampus. MTR histogram parameters of NAGM and NAWM were correlated with EDSS and MSFC scores, with lesion volume and with normalized brain volume. We conclude that disease-induced MTR changes were small in MS NAWM and NAGM, but did correlate with clinical decline, lesion volume and overall cerebral atrophy.

Original languageEnglish
Pages (from-to)708-716
Number of pages9
JournalMultiple Sclerosis
Volume13
Issue number6
DOIs
Publication statusPublished - 1 Jul 2007

Cite this

@article{34fb0ab0c1bc43cfbe5afc3f35ac7f06,
title = "Magnetization transfer ratio measurement in multiple sclerosis normal-appearing brain tissue: Limited differences with controls but relationships with clinical and MR measures of disease",
abstract = "We investigated the magnetization transfer ratio (MTR) of normal-appearing white (NAWM) and grey matter (NAGM) in a relatively large group of multiple sclerosis (MS) patients, and the relations of MTR changes with clinical disability. MTR was measured in 66 MS patients (12 PP, 35 RR, 19 SP) and 23 healthy controls, using a whole-brain 3D-FLASH technique corrected post-hoc for B1-induced variation. Histogram parameters of conservatively selected NAWM and cortical NAGM were analysed using Bonferroni-corrected ANOVA with age as covariate. Additionally, manually outlined regions of interest were analysed using a multilevel method. Lesions had low MTR (mean 22.7 ± 6.9{\%}), but NAWM exhibited limited changes: MTR histogram peak position was 32.8 ± 1.0{\%} in controls and 32.4 ± 0.9{\%} in MS patients, with a significant decrease compared to controls only in SPMS patients (31.9 ± 1.1{\%}, p=0.045). Cortical NAGM histograms did not differ significantly between patients and controls. In SPMS, regional mean MTR was significantly decreased in corpus callosum and hippocampus. MTR histogram parameters of NAGM and NAWM were correlated with EDSS and MSFC scores, with lesion volume and with normalized brain volume. We conclude that disease-induced MTR changes were small in MS NAWM and NAGM, but did correlate with clinical decline, lesion volume and overall cerebral atrophy.",
keywords = "B correction, Magnetization transfer, Multiple sclerosis, Normal-appearing brain tissue",
author = "H. Vrenken and Pouwels, {P. J W} and S. Ropele and Knol, {D. L.} and Geurts, {J. J G} and Polman, {C. H.} and F. Barkhof and Castelijns, {J. A.}",
year = "2007",
month = "7",
day = "1",
doi = "10.1177/1352458506075521",
language = "English",
volume = "13",
pages = "708--716",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "6",

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TY - JOUR

T1 - Magnetization transfer ratio measurement in multiple sclerosis normal-appearing brain tissue

T2 - Limited differences with controls but relationships with clinical and MR measures of disease

AU - Vrenken, H.

AU - Pouwels, P. J W

AU - Ropele, S.

AU - Knol, D. L.

AU - Geurts, J. J G

AU - Polman, C. H.

AU - Barkhof, F.

AU - Castelijns, J. A.

PY - 2007/7/1

Y1 - 2007/7/1

N2 - We investigated the magnetization transfer ratio (MTR) of normal-appearing white (NAWM) and grey matter (NAGM) in a relatively large group of multiple sclerosis (MS) patients, and the relations of MTR changes with clinical disability. MTR was measured in 66 MS patients (12 PP, 35 RR, 19 SP) and 23 healthy controls, using a whole-brain 3D-FLASH technique corrected post-hoc for B1-induced variation. Histogram parameters of conservatively selected NAWM and cortical NAGM were analysed using Bonferroni-corrected ANOVA with age as covariate. Additionally, manually outlined regions of interest were analysed using a multilevel method. Lesions had low MTR (mean 22.7 ± 6.9%), but NAWM exhibited limited changes: MTR histogram peak position was 32.8 ± 1.0% in controls and 32.4 ± 0.9% in MS patients, with a significant decrease compared to controls only in SPMS patients (31.9 ± 1.1%, p=0.045). Cortical NAGM histograms did not differ significantly between patients and controls. In SPMS, regional mean MTR was significantly decreased in corpus callosum and hippocampus. MTR histogram parameters of NAGM and NAWM were correlated with EDSS and MSFC scores, with lesion volume and with normalized brain volume. We conclude that disease-induced MTR changes were small in MS NAWM and NAGM, but did correlate with clinical decline, lesion volume and overall cerebral atrophy.

AB - We investigated the magnetization transfer ratio (MTR) of normal-appearing white (NAWM) and grey matter (NAGM) in a relatively large group of multiple sclerosis (MS) patients, and the relations of MTR changes with clinical disability. MTR was measured in 66 MS patients (12 PP, 35 RR, 19 SP) and 23 healthy controls, using a whole-brain 3D-FLASH technique corrected post-hoc for B1-induced variation. Histogram parameters of conservatively selected NAWM and cortical NAGM were analysed using Bonferroni-corrected ANOVA with age as covariate. Additionally, manually outlined regions of interest were analysed using a multilevel method. Lesions had low MTR (mean 22.7 ± 6.9%), but NAWM exhibited limited changes: MTR histogram peak position was 32.8 ± 1.0% in controls and 32.4 ± 0.9% in MS patients, with a significant decrease compared to controls only in SPMS patients (31.9 ± 1.1%, p=0.045). Cortical NAGM histograms did not differ significantly between patients and controls. In SPMS, regional mean MTR was significantly decreased in corpus callosum and hippocampus. MTR histogram parameters of NAGM and NAWM were correlated with EDSS and MSFC scores, with lesion volume and with normalized brain volume. We conclude that disease-induced MTR changes were small in MS NAWM and NAGM, but did correlate with clinical decline, lesion volume and overall cerebral atrophy.

KW - B correction

KW - Magnetization transfer

KW - Multiple sclerosis

KW - Normal-appearing brain tissue

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U2 - 10.1177/1352458506075521

DO - 10.1177/1352458506075521

M3 - Article

VL - 13

SP - 708

EP - 716

JO - Multiple Sclerosis

JF - Multiple Sclerosis

SN - 1352-4585

IS - 6

ER -