Management of Multiple Secreting Paragangliomas in a Succinate Dehydrogenase Subunit D (SDHD) Variant Carrier

Johannes Rijken; Berry de Vos; René Leemans; Ben Zwezerijnen; Pim de Graaf; Erik Hensen; Koen Dreijerink; Chris Dickhoff; Petr Symersky

doi:10.1016/j.athoracsur.2019.05.037

Management of Multiple Secreting Paragangliomas in a Succinate Dehydrogenase Subunit D (SDHD) Variant Carrier

Johannes Rijken, Berry de Vos, René Leemans, Ben Zwezerijnen, Pim de Graaf, Erik Hensen, Koen Dreijerink, Chris Dickhoff, Petr Symersky

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Management of functional intrathoracic sympathetic paragangliomas in succinate dehydrogenase subunit D (SDHD) mutation carriers is challenging, and there is no uniform guideline for treatment to date. The risks of potential malignant behavior and long-term cardiovascular morbidity have to be weighed against the risks of treatment complications. We report the multidisciplinary and shared decision-making approach that resulted in successful surgical removal of 3 paragangliomas in a SDHD mutation carrier.

Original language	English
Pages (from-to)	e87-e90
Journal	The Annals of Thoracic Surgery
Volume	109
Issue number	2
DOIs	https://doi.org/10.1016/j.athoracsur.2019.05.037
Publication status	Published - 1 Feb 2020

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abstract = "Management of functional intrathoracic sympathetic paragangliomas in succinate dehydrogenase subunit D (SDHD) mutation carriers is challenging, and there is no uniform guideline for treatment to date. The risks of potential malignant behavior and long-term cardiovascular morbidity have to be weighed against the risks of treatment complications. We report the multidisciplinary and shared decision-making approach that resulted in successful surgical removal of 3 paragangliomas in a SDHD mutation carrier.",

author = "Johannes Rijken and {de Vos}, Berry and Ren{\'e} Leemans and Ben Zwezerijnen and {de Graaf}, Pim and Erik Hensen and Koen Dreijerink and Chris Dickhoff and Petr Symersky",

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AU - Rijken, Johannes

AU - de Vos, Berry

AU - Leemans, René

AU - Zwezerijnen, Ben

AU - de Graaf, Pim

AU - Hensen, Erik

AU - Dreijerink, Koen

AU - Dickhoff, Chris

AU - Symersky, Petr

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AB - Management of functional intrathoracic sympathetic paragangliomas in succinate dehydrogenase subunit D (SDHD) mutation carriers is challenging, and there is no uniform guideline for treatment to date. The risks of potential malignant behavior and long-term cardiovascular morbidity have to be weighed against the risks of treatment complications. We report the multidisciplinary and shared decision-making approach that resulted in successful surgical removal of 3 paragangliomas in a SDHD mutation carrier.

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ER -

Management of Multiple Secreting Paragangliomas in a Succinate Dehydrogenase Subunit D (SDHD) Variant Carrier

Abstract

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