Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium

Xiang-Zhen Kong, Premika S. W. Boedhoe, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Paul D. Arnold, Francesca Assogna, Justin T. Baker, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Brian P. Brennan, Jan Buitelaar, Rosa Calvo, Yuqi Cheng, Kang Ik K. Cho, Sara Dallaspezia & 32 others Damiaan Denys, Benjamin A. Ely, Jamie Feusner, Kate D. Fitzgerald, Jean-Paul Fouche, Egill A. Fridgeirsson, David C. Glahn, Patricia Gruner, Deniz A. Gürsel, Tobias U. Hauser, Yoshiyuki Hirano, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Anthony James, Fern Jaspers-Fayer, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Masaru Kuno, Gerd Kvale, Jun Soo Kwon, Lianne Schmaal, Froukje E. de Vries, Stella J. de Wit, Martijn Figee, Anders Lillevik Thorsen, Ysbrand D. van der Werf, Dick J. Veltman, Odile A. van den Heuvel, Clyde Francks, ENIGMA OCD Working Group

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. Methods: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. Results: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = −0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. Conclusions: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.
Original languageEnglish
JournalBiological Psychiatry
DOIs
Publication statusE-pub ahead of print - 30 Apr 2019

Cite this

Kong, X-Z., Boedhoe, P. S. W., Abe, Y., Alonso, P., Ameis, S. H., Arnold, P. D., ... ENIGMA OCD Working Group (2019). Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2019.04.022
Kong, Xiang-Zhen ; Boedhoe, Premika S. W. ; Abe, Yoshinari ; Alonso, Pino ; Ameis, Stephanie H. ; Arnold, Paul D. ; Assogna, Francesca ; Baker, Justin T. ; Batistuzzo, Marcelo C. ; Benedetti, Francesco ; Beucke, Jan C. ; Bollettini, Irene ; Bose, Anushree ; Brem, Silvia ; Brennan, Brian P. ; Buitelaar, Jan ; Calvo, Rosa ; Cheng, Yuqi ; Cho, Kang Ik K. ; Dallaspezia, Sara ; Denys, Damiaan ; Ely, Benjamin A. ; Feusner, Jamie ; Fitzgerald, Kate D. ; Fouche, Jean-Paul ; Fridgeirsson, Egill A. ; Glahn, David C. ; Gruner, Patricia ; Gürsel, Deniz A. ; Hauser, Tobias U. ; Hirano, Yoshiyuki ; Hoexter, Marcelo Q. ; Hu, Hao ; Huyser, Chaim ; James, Anthony ; Jaspers-Fayer, Fern ; Kathmann, Norbert ; Kaufmann, Christian ; Koch, Kathrin ; Kuno, Masaru ; Kvale, Gerd ; Kwon, Jun Soo ; Schmaal, Lianne ; de Vries, Froukje E. ; de Wit, Stella J. ; Figee, Martijn ; Thorsen, Anders Lillevik ; van der Werf, Ysbrand D. ; Veltman, Dick J. ; van den Heuvel, Odile A. ; Francks, Clyde ; ENIGMA OCD Working Group. / Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium. In: Biological Psychiatry. 2019.
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title = "Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium",
abstract = "Background: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. Methods: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. Results: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = −0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. Conclusions: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.",
author = "Xiang-Zhen Kong and Boedhoe, {Premika S. W.} and Yoshinari Abe and Pino Alonso and Ameis, {Stephanie H.} and Arnold, {Paul D.} and Francesca Assogna and Baker, {Justin T.} and Batistuzzo, {Marcelo C.} and Francesco Benedetti and Beucke, {Jan C.} and Irene Bollettini and Anushree Bose and Silvia Brem and Brennan, {Brian P.} and Jan Buitelaar and Rosa Calvo and Yuqi Cheng and Cho, {Kang Ik K.} and Sara Dallaspezia and Damiaan Denys and Ely, {Benjamin A.} and Jamie Feusner and Fitzgerald, {Kate D.} and Jean-Paul Fouche and Fridgeirsson, {Egill A.} and Glahn, {David C.} and Patricia Gruner and G{\"u}rsel, {Deniz A.} and Hauser, {Tobias U.} and Yoshiyuki Hirano and Hoexter, {Marcelo Q.} and Hao Hu and Chaim Huyser and Anthony James and Fern Jaspers-Fayer and Norbert Kathmann and Christian Kaufmann and Kathrin Koch and Masaru Kuno and Gerd Kvale and Kwon, {Jun Soo} and Lianne Schmaal and {de Vries}, {Froukje E.} and {de Wit}, {Stella J.} and Martijn Figee and Thorsen, {Anders Lillevik} and {van der Werf}, {Ysbrand D.} and Veltman, {Dick J.} and {van den Heuvel}, {Odile A.} and Clyde Francks and {ENIGMA OCD Working Group}",
year = "2019",
month = "4",
day = "30",
doi = "10.1016/j.biopsych.2019.04.022",
language = "English",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",

}

Kong, X-Z, Boedhoe, PSW, Abe, Y, Alonso, P, Ameis, SH, Arnold, PD, Assogna, F, Baker, JT, Batistuzzo, MC, Benedetti, F, Beucke, JC, Bollettini, I, Bose, A, Brem, S, Brennan, BP, Buitelaar, J, Calvo, R, Cheng, Y, Cho, KIK, Dallaspezia, S, Denys, D, Ely, BA, Feusner, J, Fitzgerald, KD, Fouche, J-P, Fridgeirsson, EA, Glahn, DC, Gruner, P, Gürsel, DA, Hauser, TU, Hirano, Y, Hoexter, MQ, Hu, H, Huyser, C, James, A, Jaspers-Fayer, F, Kathmann, N, Kaufmann, C, Koch, K, Kuno, M, Kvale, G, Kwon, JS, Schmaal, L, de Vries, FE, de Wit, SJ, Figee, M, Thorsen, AL, van der Werf, YD, Veltman, DJ, van den Heuvel, OA, Francks, C & ENIGMA OCD Working Group 2019, 'Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium' Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2019.04.022

Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium. / Kong, Xiang-Zhen; Boedhoe, Premika S. W.; Abe, Yoshinari; Alonso, Pino; Ameis, Stephanie H.; Arnold, Paul D.; Assogna, Francesca; Baker, Justin T.; Batistuzzo, Marcelo C.; Benedetti, Francesco; Beucke, Jan C.; Bollettini, Irene; Bose, Anushree; Brem, Silvia; Brennan, Brian P.; Buitelaar, Jan; Calvo, Rosa; Cheng, Yuqi; Cho, Kang Ik K.; Dallaspezia, Sara; Denys, Damiaan; Ely, Benjamin A.; Feusner, Jamie; Fitzgerald, Kate D.; Fouche, Jean-Paul; Fridgeirsson, Egill A.; Glahn, David C.; Gruner, Patricia; Gürsel, Deniz A.; Hauser, Tobias U.; Hirano, Yoshiyuki; Hoexter, Marcelo Q.; Hu, Hao; Huyser, Chaim; James, Anthony; Jaspers-Fayer, Fern; Kathmann, Norbert; Kaufmann, Christian; Koch, Kathrin; Kuno, Masaru; Kvale, Gerd; Kwon, Jun Soo; Schmaal, Lianne; de Vries, Froukje E.; de Wit, Stella J.; Figee, Martijn; Thorsen, Anders Lillevik; van der Werf, Ysbrand D.; Veltman, Dick J.; van den Heuvel, Odile A.; Francks, Clyde; ENIGMA OCD Working Group.

In: Biological Psychiatry, 30.04.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium

AU - Kong, Xiang-Zhen

AU - Boedhoe, Premika S. W.

AU - Abe, Yoshinari

AU - Alonso, Pino

AU - Ameis, Stephanie H.

AU - Arnold, Paul D.

AU - Assogna, Francesca

AU - Baker, Justin T.

AU - Batistuzzo, Marcelo C.

AU - Benedetti, Francesco

AU - Beucke, Jan C.

AU - Bollettini, Irene

AU - Bose, Anushree

AU - Brem, Silvia

AU - Brennan, Brian P.

AU - Buitelaar, Jan

AU - Calvo, Rosa

AU - Cheng, Yuqi

AU - Cho, Kang Ik K.

AU - Dallaspezia, Sara

AU - Denys, Damiaan

AU - Ely, Benjamin A.

AU - Feusner, Jamie

AU - Fitzgerald, Kate D.

AU - Fouche, Jean-Paul

AU - Fridgeirsson, Egill A.

AU - Glahn, David C.

AU - Gruner, Patricia

AU - Gürsel, Deniz A.

AU - Hauser, Tobias U.

AU - Hirano, Yoshiyuki

AU - Hoexter, Marcelo Q.

AU - Hu, Hao

AU - Huyser, Chaim

AU - James, Anthony

AU - Jaspers-Fayer, Fern

AU - Kathmann, Norbert

AU - Kaufmann, Christian

AU - Koch, Kathrin

AU - Kuno, Masaru

AU - Kvale, Gerd

AU - Kwon, Jun Soo

AU - Schmaal, Lianne

AU - de Vries, Froukje E.

AU - de Wit, Stella J.

AU - Figee, Martijn

AU - Thorsen, Anders Lillevik

AU - van der Werf, Ysbrand D.

AU - Veltman, Dick J.

AU - van den Heuvel, Odile A.

AU - Francks, Clyde

AU - ENIGMA OCD Working Group

PY - 2019/4/30

Y1 - 2019/4/30

N2 - Background: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. Methods: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. Results: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = −0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. Conclusions: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.

AB - Background: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. Methods: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. Results: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = −0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. Conclusions: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85066780035&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/31178097

U2 - 10.1016/j.biopsych.2019.04.022

DO - 10.1016/j.biopsych.2019.04.022

M3 - Article

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

ER -