Mast cells are increased in the media of coronary lesions in patients with myocardial infarction and may favor atherosclerotic plaque instability

Koba Kupreishvili, Wessel W Fuijkschot, Alexander B A Vonk, Yvo M Smulders, Wim Stooker, Victor W M Van Hinsbergh, Hans W M Niessen, Paul A J Krijnen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVES: Mast cells (MCs) may play an important role in plaque destabilization and atherosclerotic coronary complications. Here, we have studied the presence of MCs in the intima and media of unstable and stable coronary lesions at different time points after myocardial infarction (MI).

METHODS: Coronary arteries were obtained at autopsy from patients with acute MI (up to 5 days old; n=27) and with chronic MI (5-14 days old; n=18), as well as sections from controls without cardiac disease (n=10). Herein, tryptase-positive MCs were quantified in the intima and media of both unstable and stable atherosclerotic plaques in infarct-related and non-infarct-related coronary arteries.

RESULTS: In the media of both acute and chronic MI patients, the number of MCs was significantly higher than in controls. This was also found when evaluating unstable and stable plaques separately. In patients with chronic MI, the number of MCs in unstable lesions was significantly higher than in stable lesions. This coincided with a significant increase in the relative number of unstable plaques in patients with chronic MI compared with control and acute MI. No differences in MC density were found between infarct-related and non-infarct-related coronary arteries in patients with MI.

CONCLUSION: The presence of MCs in the media of both stable and unstable atherosclerotic coronary lesions after MI suggests that MCs may be involved in the onset of MI and, on the other hand, that MI triggers intra-plaque infiltration of MCs especially in unstable plaques, possibly increasing the risk of re-infarction.

Original languageEnglish
Pages (from-to)548-554
Number of pages7
JournalJournal of Cardiology
Volume69
Issue number3
DOIs
Publication statusPublished - Mar 2017

Cite this

@article{9dd83f887ec149fca85e49441a98142c,
title = "Mast cells are increased in the media of coronary lesions in patients with myocardial infarction and may favor atherosclerotic plaque instability",
abstract = "OBJECTIVES: Mast cells (MCs) may play an important role in plaque destabilization and atherosclerotic coronary complications. Here, we have studied the presence of MCs in the intima and media of unstable and stable coronary lesions at different time points after myocardial infarction (MI).METHODS: Coronary arteries were obtained at autopsy from patients with acute MI (up to 5 days old; n=27) and with chronic MI (5-14 days old; n=18), as well as sections from controls without cardiac disease (n=10). Herein, tryptase-positive MCs were quantified in the intima and media of both unstable and stable atherosclerotic plaques in infarct-related and non-infarct-related coronary arteries.RESULTS: In the media of both acute and chronic MI patients, the number of MCs was significantly higher than in controls. This was also found when evaluating unstable and stable plaques separately. In patients with chronic MI, the number of MCs in unstable lesions was significantly higher than in stable lesions. This coincided with a significant increase in the relative number of unstable plaques in patients with chronic MI compared with control and acute MI. No differences in MC density were found between infarct-related and non-infarct-related coronary arteries in patients with MI.CONCLUSION: The presence of MCs in the media of both stable and unstable atherosclerotic coronary lesions after MI suggests that MCs may be involved in the onset of MI and, on the other hand, that MI triggers intra-plaque infiltration of MCs especially in unstable plaques, possibly increasing the risk of re-infarction.",
keywords = "Myocardial infarction, Mast cells, Atherosclerosis, Plaque stability",
author = "Koba Kupreishvili and Fuijkschot, {Wessel W} and Vonk, {Alexander B A} and Smulders, {Yvo M} and Wim Stooker and {Van Hinsbergh}, {Victor W M} and Niessen, {Hans W M} and Krijnen, {Paul A J}",
note = "Copyright {\circledC} 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.",
year = "2017",
month = "3",
doi = "10.1016/j.jjcc.2016.04.018",
language = "English",
volume = "69",
pages = "548--554",
journal = "Journal of Cardiology",
issn = "0914-5087",
number = "3",

}

Mast cells are increased in the media of coronary lesions in patients with myocardial infarction and may favor atherosclerotic plaque instability. / Kupreishvili, Koba; Fuijkschot, Wessel W; Vonk, Alexander B A; Smulders, Yvo M; Stooker, Wim; Van Hinsbergh, Victor W M; Niessen, Hans W M; Krijnen, Paul A J.

In: Journal of Cardiology, Vol. 69, No. 3, 03.2017, p. 548-554.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Mast cells are increased in the media of coronary lesions in patients with myocardial infarction and may favor atherosclerotic plaque instability

AU - Kupreishvili, Koba

AU - Fuijkschot, Wessel W

AU - Vonk, Alexander B A

AU - Smulders, Yvo M

AU - Stooker, Wim

AU - Van Hinsbergh, Victor W M

AU - Niessen, Hans W M

AU - Krijnen, Paul A J

N1 - Copyright © 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

PY - 2017/3

Y1 - 2017/3

N2 - OBJECTIVES: Mast cells (MCs) may play an important role in plaque destabilization and atherosclerotic coronary complications. Here, we have studied the presence of MCs in the intima and media of unstable and stable coronary lesions at different time points after myocardial infarction (MI).METHODS: Coronary arteries were obtained at autopsy from patients with acute MI (up to 5 days old; n=27) and with chronic MI (5-14 days old; n=18), as well as sections from controls without cardiac disease (n=10). Herein, tryptase-positive MCs were quantified in the intima and media of both unstable and stable atherosclerotic plaques in infarct-related and non-infarct-related coronary arteries.RESULTS: In the media of both acute and chronic MI patients, the number of MCs was significantly higher than in controls. This was also found when evaluating unstable and stable plaques separately. In patients with chronic MI, the number of MCs in unstable lesions was significantly higher than in stable lesions. This coincided with a significant increase in the relative number of unstable plaques in patients with chronic MI compared with control and acute MI. No differences in MC density were found between infarct-related and non-infarct-related coronary arteries in patients with MI.CONCLUSION: The presence of MCs in the media of both stable and unstable atherosclerotic coronary lesions after MI suggests that MCs may be involved in the onset of MI and, on the other hand, that MI triggers intra-plaque infiltration of MCs especially in unstable plaques, possibly increasing the risk of re-infarction.

AB - OBJECTIVES: Mast cells (MCs) may play an important role in plaque destabilization and atherosclerotic coronary complications. Here, we have studied the presence of MCs in the intima and media of unstable and stable coronary lesions at different time points after myocardial infarction (MI).METHODS: Coronary arteries were obtained at autopsy from patients with acute MI (up to 5 days old; n=27) and with chronic MI (5-14 days old; n=18), as well as sections from controls without cardiac disease (n=10). Herein, tryptase-positive MCs were quantified in the intima and media of both unstable and stable atherosclerotic plaques in infarct-related and non-infarct-related coronary arteries.RESULTS: In the media of both acute and chronic MI patients, the number of MCs was significantly higher than in controls. This was also found when evaluating unstable and stable plaques separately. In patients with chronic MI, the number of MCs in unstable lesions was significantly higher than in stable lesions. This coincided with a significant increase in the relative number of unstable plaques in patients with chronic MI compared with control and acute MI. No differences in MC density were found between infarct-related and non-infarct-related coronary arteries in patients with MI.CONCLUSION: The presence of MCs in the media of both stable and unstable atherosclerotic coronary lesions after MI suggests that MCs may be involved in the onset of MI and, on the other hand, that MI triggers intra-plaque infiltration of MCs especially in unstable plaques, possibly increasing the risk of re-infarction.

KW - Myocardial infarction

KW - Mast cells

KW - Atherosclerosis

KW - Plaque stability

U2 - 10.1016/j.jjcc.2016.04.018

DO - 10.1016/j.jjcc.2016.04.018

M3 - Article

VL - 69

SP - 548

EP - 554

JO - Journal of Cardiology

JF - Journal of Cardiology

SN - 0914-5087

IS - 3

ER -