Maternal deprivation of rat pups increases clinical symptoms of experimental autoimmune encephalomyelitis at adult age

Marc A T Teunis, Cobi J Heijnen, Frans Sluyter, Joost M Bakker, Anne-Marie M W Van Dam, Maleen Hof, Alexander R Cools, Annemieke Kavelaars

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Abstract

Maternal deprivation of neonatal animals has been shown to induce long-lasting changes in the reactivity of the neuroendocrine system. The aim of the present study was to investigate whether maternal deprivation also affects susceptibility to immune-mediated diseases such as experimental autoimmune encephalomyelitis (EAE) in adult life. To this end, 9-day-old rat pups were subjected to a short-lasting maternal deprivation for a period of 24 h. At the age of 8 weeks, we induced EAE in these rats by immunization with myelin basic protein (MBP) in complete Freund's adjuvant. Our data demonstrate that short-lasting maternal deprivation induces a marked increase in the severity of EAE in the animals in later life. The histopathological evaluation of spinal cord and cerebellum corresponded with the observed differences in clinical symptoms of EAE. Moreover, neonatal maternal deprivation affects macrophage functioning at adult age. In contrast, no differences were observed in in vitro mitogen- and MBP-induced cytokine production by splenocytes. LPS-induced corticosterone release did not differ either between maternally deprived and control animals. We conclude that short-lasting neonatal maternal deprivation of rat pups has long-lasting consequences for macrophage activity and for susceptibility to the inflammatory autoimmune disease EAE.

Original languageEnglish
Pages (from-to)30-8
Number of pages9
JournalJournal of Neuroimmunology
Volume133
Issue number1-2
Publication statusPublished - Dec 2002

Cite this

Teunis, M. A. T., Heijnen, C. J., Sluyter, F., Bakker, J. M., Van Dam, A-M. M. W., Hof, M., ... Kavelaars, A. (2002). Maternal deprivation of rat pups increases clinical symptoms of experimental autoimmune encephalomyelitis at adult age. Journal of Neuroimmunology, 133(1-2), 30-8.