Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions

Catharina M P Vos, Elise S van Haastert, Corline J A de Groot, Paul van der Valk, Helga E de Vries

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Matrix metalloproteinases (MMPs) are proteases involved in extracellular matrix (ECM) remodeling, leukocyte infiltration into lesions and myelin degradation in the central nervous system (CNS) disease multiple sclerosis (MS). We have investigated whether MMP-12 (macrophage metalloelastase) is expressed in MS lesions at various stages. In control patient tissue and (p)reactive MS lesions, only occasional microglial and astrocyte staining was detected. In contrast, in active demyelinating lesions, phagocytic macrophages were MMP-12 positive. A lower proportion of phagocytes was positive for MMP-12 in chronic active demyelinating lesions and inactive lesions. This suggests a role for MMP-12 during demyelination in MS.

Original languageEnglish
Pages (from-to)106-14
Number of pages9
JournalJournal of Neuroimmunology
Volume138
Issue number1-2
Publication statusPublished - May 2003

Cite this

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title = "Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions",
abstract = "Matrix metalloproteinases (MMPs) are proteases involved in extracellular matrix (ECM) remodeling, leukocyte infiltration into lesions and myelin degradation in the central nervous system (CNS) disease multiple sclerosis (MS). We have investigated whether MMP-12 (macrophage metalloelastase) is expressed in MS lesions at various stages. In control patient tissue and (p)reactive MS lesions, only occasional microglial and astrocyte staining was detected. In contrast, in active demyelinating lesions, phagocytic macrophages were MMP-12 positive. A lower proportion of phagocytes was positive for MMP-12 in chronic active demyelinating lesions and inactive lesions. This suggests a role for MMP-12 during demyelination in MS.",
keywords = "Adult, Aged, Aged, 80 and over, Brain/enzymology, Female, Humans, Immunohistochemistry, Macrophages/enzymology, Male, Matrix Metalloproteinase 12, Metalloendopeptidases/biosynthesis, Middle Aged, Multiple Sclerosis/enzymology, Multiple Sclerosis, Chronic Progressive/enzymology, Palatine Tonsil/cytology, Phagocytosis, Placenta/cytology, Retrospective Studies, Spleen/cytology",
author = "Vos, {Catharina M P} and {van Haastert}, {Elise S} and {de Groot}, {Corline J A} and {van der Valk}, Paul and {de Vries}, {Helga E}",
year = "2003",
month = "5",
language = "English",
volume = "138",
pages = "106--14",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

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Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions. / Vos, Catharina M P; van Haastert, Elise S; de Groot, Corline J A; van der Valk, Paul; de Vries, Helga E.

In: Journal of Neuroimmunology, Vol. 138, No. 1-2, 05.2003, p. 106-14.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions

AU - Vos, Catharina M P

AU - van Haastert, Elise S

AU - de Groot, Corline J A

AU - van der Valk, Paul

AU - de Vries, Helga E

PY - 2003/5

Y1 - 2003/5

N2 - Matrix metalloproteinases (MMPs) are proteases involved in extracellular matrix (ECM) remodeling, leukocyte infiltration into lesions and myelin degradation in the central nervous system (CNS) disease multiple sclerosis (MS). We have investigated whether MMP-12 (macrophage metalloelastase) is expressed in MS lesions at various stages. In control patient tissue and (p)reactive MS lesions, only occasional microglial and astrocyte staining was detected. In contrast, in active demyelinating lesions, phagocytic macrophages were MMP-12 positive. A lower proportion of phagocytes was positive for MMP-12 in chronic active demyelinating lesions and inactive lesions. This suggests a role for MMP-12 during demyelination in MS.

AB - Matrix metalloproteinases (MMPs) are proteases involved in extracellular matrix (ECM) remodeling, leukocyte infiltration into lesions and myelin degradation in the central nervous system (CNS) disease multiple sclerosis (MS). We have investigated whether MMP-12 (macrophage metalloelastase) is expressed in MS lesions at various stages. In control patient tissue and (p)reactive MS lesions, only occasional microglial and astrocyte staining was detected. In contrast, in active demyelinating lesions, phagocytic macrophages were MMP-12 positive. A lower proportion of phagocytes was positive for MMP-12 in chronic active demyelinating lesions and inactive lesions. This suggests a role for MMP-12 during demyelination in MS.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Brain/enzymology

KW - Female

KW - Humans

KW - Immunohistochemistry

KW - Macrophages/enzymology

KW - Male

KW - Matrix Metalloproteinase 12

KW - Metalloendopeptidases/biosynthesis

KW - Middle Aged

KW - Multiple Sclerosis/enzymology

KW - Multiple Sclerosis, Chronic Progressive/enzymology

KW - Palatine Tonsil/cytology

KW - Phagocytosis

KW - Placenta/cytology

KW - Retrospective Studies

KW - Spleen/cytology

M3 - Article

VL - 138

SP - 106

EP - 114

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -