Measurement of cardiac output by open-circuit acetylene uptake: a computer model to quantify error caused by ventilation-perfusion inequality

Harm J Bogaard, Peter D Wagner

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The ability to assess cardiac output (Q(T)) noninvasively has been the focus of interest for many researchers. While the open-circuit acetylene (C2H2) method seems promising, it is prone to error due to ventilation-perfusion (V/Q) inequality. Measurements during exercise, at high altitude or in patients with chronic obstructive pulmonary disease (COPD) could be unreliable and further validation studies under these circumstances may be needed. We used a computer model based on formulae derived from the multiple inert gas elimination technique to quantify error in Q(T) measurements resulting from V/Q inequality at rest, during exercise or at high altitude. Moreover, potential errors encountered in patients with COPD were quantified. In healthy subjects, V/Q inequality related measurement error seems negligible, under both normoxic and hypoxic conditions and especially during exercise. In COPD, errors up to 20% at rest and up to 15% during exercise are expected. It is therefore concluded from our model that the open-circuit C2H2 uptake method is expected to be accurate in normal subjects. Its validity in COPD needs further study.

Original languageEnglish
Pages (from-to)1023-32
Number of pages10
JournalPhysiological Measurement
Volume27
Issue number10
DOIs
Publication statusPublished - Oct 2006

Cite this

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title = "Measurement of cardiac output by open-circuit acetylene uptake: a computer model to quantify error caused by ventilation-perfusion inequality",
abstract = "The ability to assess cardiac output (Q(T)) noninvasively has been the focus of interest for many researchers. While the open-circuit acetylene (C2H2) method seems promising, it is prone to error due to ventilation-perfusion (V/Q) inequality. Measurements during exercise, at high altitude or in patients with chronic obstructive pulmonary disease (COPD) could be unreliable and further validation studies under these circumstances may be needed. We used a computer model based on formulae derived from the multiple inert gas elimination technique to quantify error in Q(T) measurements resulting from V/Q inequality at rest, during exercise or at high altitude. Moreover, potential errors encountered in patients with COPD were quantified. In healthy subjects, V/Q inequality related measurement error seems negligible, under both normoxic and hypoxic conditions and especially during exercise. In COPD, errors up to 20{\%} at rest and up to 15{\%} during exercise are expected. It is therefore concluded from our model that the open-circuit C2H2 uptake method is expected to be accurate in normal subjects. Its validity in COPD needs further study.",
keywords = "Acetylene, Cardiac Output/physiology, Computer Simulation, Exercise/physiology, Humans, Hypoxia/physiopathology, Models, Biological, Pulmonary Disease, Chronic Obstructive/physiopathology, Ventilation-Perfusion Ratio/physiology",
author = "Bogaard, {Harm J} and Wagner, {Peter D}",
year = "2006",
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language = "English",
volume = "27",
pages = "1023--32",
journal = "Physiological Measurement",
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Measurement of cardiac output by open-circuit acetylene uptake : a computer model to quantify error caused by ventilation-perfusion inequality. / Bogaard, Harm J; Wagner, Peter D.

In: Physiological Measurement, Vol. 27, No. 10, 10.2006, p. 1023-32.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Measurement of cardiac output by open-circuit acetylene uptake

T2 - a computer model to quantify error caused by ventilation-perfusion inequality

AU - Bogaard, Harm J

AU - Wagner, Peter D

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N2 - The ability to assess cardiac output (Q(T)) noninvasively has been the focus of interest for many researchers. While the open-circuit acetylene (C2H2) method seems promising, it is prone to error due to ventilation-perfusion (V/Q) inequality. Measurements during exercise, at high altitude or in patients with chronic obstructive pulmonary disease (COPD) could be unreliable and further validation studies under these circumstances may be needed. We used a computer model based on formulae derived from the multiple inert gas elimination technique to quantify error in Q(T) measurements resulting from V/Q inequality at rest, during exercise or at high altitude. Moreover, potential errors encountered in patients with COPD were quantified. In healthy subjects, V/Q inequality related measurement error seems negligible, under both normoxic and hypoxic conditions and especially during exercise. In COPD, errors up to 20% at rest and up to 15% during exercise are expected. It is therefore concluded from our model that the open-circuit C2H2 uptake method is expected to be accurate in normal subjects. Its validity in COPD needs further study.

AB - The ability to assess cardiac output (Q(T)) noninvasively has been the focus of interest for many researchers. While the open-circuit acetylene (C2H2) method seems promising, it is prone to error due to ventilation-perfusion (V/Q) inequality. Measurements during exercise, at high altitude or in patients with chronic obstructive pulmonary disease (COPD) could be unreliable and further validation studies under these circumstances may be needed. We used a computer model based on formulae derived from the multiple inert gas elimination technique to quantify error in Q(T) measurements resulting from V/Q inequality at rest, during exercise or at high altitude. Moreover, potential errors encountered in patients with COPD were quantified. In healthy subjects, V/Q inequality related measurement error seems negligible, under both normoxic and hypoxic conditions and especially during exercise. In COPD, errors up to 20% at rest and up to 15% during exercise are expected. It is therefore concluded from our model that the open-circuit C2H2 uptake method is expected to be accurate in normal subjects. Its validity in COPD needs further study.

KW - Acetylene

KW - Cardiac Output/physiology

KW - Computer Simulation

KW - Exercise/physiology

KW - Humans

KW - Hypoxia/physiopathology

KW - Models, Biological

KW - Pulmonary Disease, Chronic Obstructive/physiopathology

KW - Ventilation-Perfusion Ratio/physiology

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