Measurement of mucosal conductivity by MII is a potential marker of mucosal integrity restored in infants on acid-suppression therapy

Clara M Loots; Michiel P Van Wijk; Marije J Smits; Tobias G Wenzl; Marc A Benninga; Taher I Omari

doi:10.1097/MPG.0b013e318214c3cc

Measurement of mucosal conductivity by MII is a potential marker of mucosal integrity restored in infants on acid-suppression therapy

Clara M Loots, Michiel P Van Wijk, Marije J Smits, Tobias G Wenzl, Marc A Benninga, Taher I Omari

Pediatric surgery

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Esophageal multichannel intraluminal impedance (MII) allows measurement of the conductivity of adjacent contents. During esophageal rest, raw impedance levels may represent mucosal integrity. We assessed the influence of proton pump inhibitors (PPIs) on presumed mucosal integrity by reanalyzing raw MII levels of 21 pH-MII tracings from infants with gastroesophageal reflux (GER) disease before and after esomeprazole treatment. Median (interquartile range) esophageal MII increased during treatment, 938 (652-1304) versus 1885 (1360-2183) Ohm, P < 0.0001. Patients with lower MII levels demonstrated a larger increase on therapy: Spearman r2 = 0.28, P = 0.014. No correlation with standard GER parameters was observed. In conclusion, PPI therapy increases MII levels in infants with symptomatic GER disease.

Original language	English
Pages (from-to)	120-3
Number of pages	4
Journal	Journal of Pediatric Gastroenterology and Nutrition
Volume	53
Issue number	1
DOIs	https://doi.org/10.1097/MPG.0b013e318214c3cc
Publication status	Published - Jul 2011

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10.1097/MPG.0b013e318214c3cc

Cite this

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title = "Measurement of mucosal conductivity by MII is a potential marker of mucosal integrity restored in infants on acid-suppression therapy",

abstract = "Esophageal multichannel intraluminal impedance (MII) allows measurement of the conductivity of adjacent contents. During esophageal rest, raw impedance levels may represent mucosal integrity. We assessed the influence of proton pump inhibitors (PPIs) on presumed mucosal integrity by reanalyzing raw MII levels of 21 pH-MII tracings from infants with gastroesophageal reflux (GER) disease before and after esomeprazole treatment. Median (interquartile range) esophageal MII increased during treatment, 938 (652-1304) versus 1885 (1360-2183) Ohm, P < 0.0001. Patients with lower MII levels demonstrated a larger increase on therapy: Spearman r2 = 0.28, P = 0.014. No correlation with standard GER parameters was observed. In conclusion, PPI therapy increases MII levels in infants with symptomatic GER disease.",

keywords = "Anti-Ulcer Agents/therapeutic use, Biomarkers, Cohort Studies, Electric Conductivity, Electrochemical Techniques, Esomeprazole/therapeutic use, Esophagus/drug effects, Gastroesophageal Reflux/diagnosis, Humans, Hydrogen-Ion Concentration, Infant, Infant, Newborn, Infant, Premature, Mucous Membrane/drug effects, Proton Pump Inhibitors/therapeutic use, Severity of Illness Index",

author = "Loots, {Clara M} and {Van Wijk}, {Michiel P} and Smits, {Marije J} and Wenzl, {Tobias G} and Benninga, {Marc A} and Omari, {Taher I}",

year = "2011",

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doi = "10.1097/MPG.0b013e318214c3cc",

language = "English",

volume = "53",

pages = "120--3",

journal = "Journal of Pediatric Gastroenterology and Nutrition",

issn = "0277-2116",

publisher = "Lippincott Williams and Wilkins",

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T1 - Measurement of mucosal conductivity by MII is a potential marker of mucosal integrity restored in infants on acid-suppression therapy

AU - Loots, Clara M

AU - Van Wijk, Michiel P

AU - Smits, Marije J

AU - Wenzl, Tobias G

AU - Benninga, Marc A

AU - Omari, Taher I

PY - 2011/7

Y1 - 2011/7

N2 - Esophageal multichannel intraluminal impedance (MII) allows measurement of the conductivity of adjacent contents. During esophageal rest, raw impedance levels may represent mucosal integrity. We assessed the influence of proton pump inhibitors (PPIs) on presumed mucosal integrity by reanalyzing raw MII levels of 21 pH-MII tracings from infants with gastroesophageal reflux (GER) disease before and after esomeprazole treatment. Median (interquartile range) esophageal MII increased during treatment, 938 (652-1304) versus 1885 (1360-2183) Ohm, P < 0.0001. Patients with lower MII levels demonstrated a larger increase on therapy: Spearman r2 = 0.28, P = 0.014. No correlation with standard GER parameters was observed. In conclusion, PPI therapy increases MII levels in infants with symptomatic GER disease.

AB - Esophageal multichannel intraluminal impedance (MII) allows measurement of the conductivity of adjacent contents. During esophageal rest, raw impedance levels may represent mucosal integrity. We assessed the influence of proton pump inhibitors (PPIs) on presumed mucosal integrity by reanalyzing raw MII levels of 21 pH-MII tracings from infants with gastroesophageal reflux (GER) disease before and after esomeprazole treatment. Median (interquartile range) esophageal MII increased during treatment, 938 (652-1304) versus 1885 (1360-2183) Ohm, P < 0.0001. Patients with lower MII levels demonstrated a larger increase on therapy: Spearman r2 = 0.28, P = 0.014. No correlation with standard GER parameters was observed. In conclusion, PPI therapy increases MII levels in infants with symptomatic GER disease.

KW - Anti-Ulcer Agents/therapeutic use

KW - Biomarkers

KW - Cohort Studies

KW - Electric Conductivity

KW - Electrochemical Techniques

KW - Esomeprazole/therapeutic use

KW - Esophagus/drug effects

KW - Gastroesophageal Reflux/diagnosis

KW - Humans

KW - Hydrogen-Ion Concentration

KW - Infant

KW - Infant, Newborn

KW - Infant, Premature

KW - Mucous Membrane/drug effects

KW - Proton Pump Inhibitors/therapeutic use

KW - Severity of Illness Index

U2 - 10.1097/MPG.0b013e318214c3cc

DO - 10.1097/MPG.0b013e318214c3cc

M3 - Article

C2 - 21694551

VL - 53

SP - 120

EP - 123

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

IS - 1

ER -