Measurement of oncometabolites D-2-hydroxyglutaric acid and L-2-hydroxyglutaric acid

Patricia M. Jones, Richard Boriack, Eduard A. Struys, Dinesh Rakheja*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

We describe a liquid chromatography-tandem mass spectrometry assay for measurement of d-2-hydroxyglutaric acid and l-2-hydroxyglutaric acid. These metabolites are increased in specific inborn errors of metabolism and are now recognized as oncometabolites. The measurement of d-2-hydroxyglutarate in peripheral blood may be used as a biomarker for screening and follow-up of patients with IDH-mutated acute myeloid leukemia.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages219-234
Number of pages16
Volume1633
DOIs
Publication statusPublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1633
ISSN (Print)1064-3745

Cite this

Jones, P. M., Boriack, R., Struys, E. A., & Rakheja, D. (2017). Measurement of oncometabolites D-2-hydroxyglutaric acid and L-2-hydroxyglutaric acid. In Methods in Molecular Biology (Vol. 1633, pp. 219-234). (Methods in Molecular Biology; Vol. 1633). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-7142-8_14