Measurement of Salivary Pepsin to Detect Gastroesophageal Reflux Disease Is Not Ready for Clinical Application

Philip Woodland, Maartje M. J. Singendonk, Joanne Ooi, Kornilia Nikaki, Terry Wong, Chung Lee, Esteban Glasinovic, Romy Koning, Rene Lutter, Marc A. Benninga, Michiel P. van Wijk, Daniel Sifrim

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A noninvasive test for gastroesophageal reflux disease (GERD) is desirable for adults and children. Salivary pepsin measurement has been proposed as such a test.1–3 A previous study from our group demonstrated that a maximal salivary pepsin cutoff of >210 ng/mL using the PepTest device (RD Biomed, Hull, United Kingdom) had excellent specificity of 96% but modest sensitivity of 44% to diagnose GERD,4 leading to optimism about its potential use. In this study, we aimed to confirm the previously reported sensitivity and specificity in healthy volunteers and patients with heartburn, evaluate the association between a positive PepTest and response to proton pump inhibitor (PPI) therapy, assess if test-sensitivity can be improved for GERD when samples are taken over a 72-hour sampling period, and establish normal values of salivary pepsin in infants.
LanguageEnglish
Pages563-565
JournalClinical Gastroenterology and Hepatology
Volume17
Issue number3
Early online date18 May 2018
DOIs
Publication statusPublished - 2019

Cite this

Woodland, Philip ; Singendonk, Maartje M. J. ; Ooi, Joanne ; Nikaki, Kornilia ; Wong, Terry ; Lee, Chung ; Glasinovic, Esteban ; Koning, Romy ; Lutter, Rene ; Benninga, Marc A. ; van Wijk, Michiel P. ; Sifrim, Daniel. / Measurement of Salivary Pepsin to Detect Gastroesophageal Reflux Disease Is Not Ready for Clinical Application. In: Clinical Gastroenterology and Hepatology. 2019 ; Vol. 17, No. 3. pp. 563-565.
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abstract = "A noninvasive test for gastroesophageal reflux disease (GERD) is desirable for adults and children. Salivary pepsin measurement has been proposed as such a test.1–3 A previous study from our group demonstrated that a maximal salivary pepsin cutoff of >210 ng/mL using the PepTest device (RD Biomed, Hull, United Kingdom) had excellent specificity of 96{\%} but modest sensitivity of 44{\%} to diagnose GERD,4 leading to optimism about its potential use. In this study, we aimed to confirm the previously reported sensitivity and specificity in healthy volunteers and patients with heartburn, evaluate the association between a positive PepTest and response to proton pump inhibitor (PPI) therapy, assess if test-sensitivity can be improved for GERD when samples are taken over a 72-hour sampling period, and establish normal values of salivary pepsin in infants.",
author = "Philip Woodland and Singendonk, {Maartje M. J.} and Joanne Ooi and Kornilia Nikaki and Terry Wong and Chung Lee and Esteban Glasinovic and Romy Koning and Rene Lutter and Benninga, {Marc A.} and {van Wijk}, {Michiel P.} and Daniel Sifrim",
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language = "English",
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Woodland, P, Singendonk, MMJ, Ooi, J, Nikaki, K, Wong, T, Lee, C, Glasinovic, E, Koning, R, Lutter, R, Benninga, MA, van Wijk, MP & Sifrim, D 2019, 'Measurement of Salivary Pepsin to Detect Gastroesophageal Reflux Disease Is Not Ready for Clinical Application', Clinical Gastroenterology and Hepatology, vol. 17, no. 3, pp. 563-565. https://doi.org/10.1016/j.cgh.2018.05.016

Measurement of Salivary Pepsin to Detect Gastroesophageal Reflux Disease Is Not Ready for Clinical Application. / Woodland, Philip; Singendonk, Maartje M. J.; Ooi, Joanne; Nikaki, Kornilia; Wong, Terry; Lee, Chung; Glasinovic, Esteban; Koning, Romy; Lutter, Rene; Benninga, Marc A.; van Wijk, Michiel P.; Sifrim, Daniel.

In: Clinical Gastroenterology and Hepatology, Vol. 17, No. 3, 2019, p. 563-565.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Wong, Terry

AU - Lee, Chung

AU - Glasinovic, Esteban

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