Measurement properties of the EQ-5D across four major geriatric conditions: Findings from TOPICS-MDS

J. E. Lutomski, P. F.M. Krabbe, Nienke Bleijenberg, Jeanett Blom, G. I.J.M. Kempen, Janet MacNeil-Vroomen, M. E. Muntinga, Ewout Steyerburg, Marcel G.M. Olde-Rikkert, René J.F. Melis, TOPICS Consortium

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: As populations age, chronic geriatric conditions linked to progressive organ failure jeopardize health-related quality of life (HRQoL). Thus, this research assessed the validity and applicability of the EQ-5D (a common HRQoL instrument) across four major chronic geriatric conditions: hearing issues, joint damage, urinary incontinence, or dizziness with falls. Methods: The study sample comprised 25,637 community-dwelling persons aged 65 years and older residing in the Netherlands (Data source: TOPICS-MDS, www.topics-mds.eu ). Floor and ceiling effects were examined. To assess convergent validity, random effects meta-correlations (Spearman's rho) were derived between individual EQ-5D domains and related survey items. To further examine construct validity, the association between sociodemographic characteristics and EQ-5D summary scores were assessed using linear mixed models. Outcomes were compared to the overall study population as well as a 'healthy' subgroup reporting no major chronic conditions. Results: Whereas ceiling effects were observed in the overall study population and the 'healthy' subgroup, such was not the case in the geriatric condition subgroups. The majority of hypotheses regarding correlations between survey items and sociodemographic associations were supported. EQ-5D summary scores were lower in respondents who were older, female, widowed/single, lower educated, and living alone. Increasing co-morbidity had a clear negative effect on EQ-5D scores. Conclusion: This study supported the construct validity of the EQ-5D across four major geriatric conditions. For older persons who are generally healthy, i.e. reporting few to no chronic conditions, the EQ-5D confers poor discriminative ability due to ceiling effects. Although the overall dataset initially suggested poor discriminative ability for the EQ-5D, such was not the case within subgroups presenting with major geriatric conditions.

Original languageEnglish
Article number45
JournalHealth and Quality of Life Outcomes
Volume15
Issue number1
DOIs
Publication statusPublished - 3 Mar 2017

Cite this

Lutomski, J. E., Krabbe, P. F. M., Bleijenberg, N., Blom, J., Kempen, G. I. J. M., MacNeil-Vroomen, J., ... TOPICS Consortium (2017). Measurement properties of the EQ-5D across four major geriatric conditions: Findings from TOPICS-MDS. Health and Quality of Life Outcomes, 15(1), [45]. https://doi.org/10.1186/s12955-017-0616-x
Lutomski, J. E. ; Krabbe, P. F.M. ; Bleijenberg, Nienke ; Blom, Jeanett ; Kempen, G. I.J.M. ; MacNeil-Vroomen, Janet ; Muntinga, M. E. ; Steyerburg, Ewout ; Olde-Rikkert, Marcel G.M. ; Melis, René J.F. ; TOPICS Consortium. / Measurement properties of the EQ-5D across four major geriatric conditions : Findings from TOPICS-MDS. In: Health and Quality of Life Outcomes. 2017 ; Vol. 15, No. 1.
@article{e635456ffd5b4d4f9f6649ab819419d5,
title = "Measurement properties of the EQ-5D across four major geriatric conditions: Findings from TOPICS-MDS",
abstract = "Background: As populations age, chronic geriatric conditions linked to progressive organ failure jeopardize health-related quality of life (HRQoL). Thus, this research assessed the validity and applicability of the EQ-5D (a common HRQoL instrument) across four major chronic geriatric conditions: hearing issues, joint damage, urinary incontinence, or dizziness with falls. Methods: The study sample comprised 25,637 community-dwelling persons aged 65 years and older residing in the Netherlands (Data source: TOPICS-MDS, www.topics-mds.eu ). Floor and ceiling effects were examined. To assess convergent validity, random effects meta-correlations (Spearman's rho) were derived between individual EQ-5D domains and related survey items. To further examine construct validity, the association between sociodemographic characteristics and EQ-5D summary scores were assessed using linear mixed models. Outcomes were compared to the overall study population as well as a 'healthy' subgroup reporting no major chronic conditions. Results: Whereas ceiling effects were observed in the overall study population and the 'healthy' subgroup, such was not the case in the geriatric condition subgroups. The majority of hypotheses regarding correlations between survey items and sociodemographic associations were supported. EQ-5D summary scores were lower in respondents who were older, female, widowed/single, lower educated, and living alone. Increasing co-morbidity had a clear negative effect on EQ-5D scores. Conclusion: This study supported the construct validity of the EQ-5D across four major geriatric conditions. For older persons who are generally healthy, i.e. reporting few to no chronic conditions, the EQ-5D confers poor discriminative ability due to ceiling effects. Although the overall dataset initially suggested poor discriminative ability for the EQ-5D, such was not the case within subgroups presenting with major geriatric conditions.",
keywords = "Dizziness, EQ-5D, Hearing loss, Joint diseases, Quality of life, Urinary incontinence",
author = "Lutomski, {J. E.} and Krabbe, {P. F.M.} and Nienke Bleijenberg and Jeanett Blom and Kempen, {G. I.J.M.} and Janet MacNeil-Vroomen and Muntinga, {M. E.} and Ewout Steyerburg and Olde-Rikkert, {Marcel G.M.} and Melis, {Ren{\'e} J.F.} and N. Bleijenberg and Blom, {J. W.} and Melis, {R. J.F.} and Muntinga, {M. E.} and Steyerberg, {E. W.} and J. Gussekloo and Olde-Rikkert, {M. G.M.} and {van den Brink}, D. and Lutomski, {J. E.} and L. Qin and Kempen, {G. I.J.M.} and Krabbe, {P. F.M.} and Buurman, {B. M.} and {van der Horst}, {H. E.} and {de Rooij}, {S. E.J.A.} and Schols, {J. M.G.A.} and Schuurmans, {M. J.} and Smilde, {D. A.} and {TOPICS Consortium}",
year = "2017",
month = "3",
day = "3",
doi = "10.1186/s12955-017-0616-x",
language = "English",
volume = "15",
journal = "Health and Quality of Life Outcomes",
issn = "1477-7525",
publisher = "BioMed Central",
number = "1",

}

Lutomski, JE, Krabbe, PFM, Bleijenberg, N, Blom, J, Kempen, GIJM, MacNeil-Vroomen, J, Muntinga, ME, Steyerburg, E, Olde-Rikkert, MGM, Melis, RJF & TOPICS Consortium 2017, 'Measurement properties of the EQ-5D across four major geriatric conditions: Findings from TOPICS-MDS' Health and Quality of Life Outcomes, vol. 15, no. 1, 45. https://doi.org/10.1186/s12955-017-0616-x

Measurement properties of the EQ-5D across four major geriatric conditions : Findings from TOPICS-MDS. / Lutomski, J. E.; Krabbe, P. F.M.; Bleijenberg, Nienke; Blom, Jeanett; Kempen, G. I.J.M.; MacNeil-Vroomen, Janet; Muntinga, M. E.; Steyerburg, Ewout; Olde-Rikkert, Marcel G.M.; Melis, René J.F.; TOPICS Consortium.

In: Health and Quality of Life Outcomes, Vol. 15, No. 1, 45, 03.03.2017.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Measurement properties of the EQ-5D across four major geriatric conditions

T2 - Findings from TOPICS-MDS

AU - Lutomski, J. E.

AU - Krabbe, P. F.M.

AU - Bleijenberg, Nienke

AU - Blom, Jeanett

AU - Kempen, G. I.J.M.

AU - MacNeil-Vroomen, Janet

AU - Muntinga, M. E.

AU - Steyerburg, Ewout

AU - Olde-Rikkert, Marcel G.M.

AU - Melis, René J.F.

AU - Bleijenberg, N.

AU - Blom, J. W.

AU - Melis, R. J.F.

AU - Muntinga, M. E.

AU - Steyerberg, E. W.

AU - Gussekloo, J.

AU - Olde-Rikkert, M. G.M.

AU - van den Brink, D.

AU - Lutomski, J. E.

AU - Qin, L.

AU - Kempen, G. I.J.M.

AU - Krabbe, P. F.M.

AU - Buurman, B. M.

AU - van der Horst, H. E.

AU - de Rooij, S. E.J.A.

AU - Schols, J. M.G.A.

AU - Schuurmans, M. J.

AU - Smilde, D. A.

AU - TOPICS Consortium

PY - 2017/3/3

Y1 - 2017/3/3

N2 - Background: As populations age, chronic geriatric conditions linked to progressive organ failure jeopardize health-related quality of life (HRQoL). Thus, this research assessed the validity and applicability of the EQ-5D (a common HRQoL instrument) across four major chronic geriatric conditions: hearing issues, joint damage, urinary incontinence, or dizziness with falls. Methods: The study sample comprised 25,637 community-dwelling persons aged 65 years and older residing in the Netherlands (Data source: TOPICS-MDS, www.topics-mds.eu ). Floor and ceiling effects were examined. To assess convergent validity, random effects meta-correlations (Spearman's rho) were derived between individual EQ-5D domains and related survey items. To further examine construct validity, the association between sociodemographic characteristics and EQ-5D summary scores were assessed using linear mixed models. Outcomes were compared to the overall study population as well as a 'healthy' subgroup reporting no major chronic conditions. Results: Whereas ceiling effects were observed in the overall study population and the 'healthy' subgroup, such was not the case in the geriatric condition subgroups. The majority of hypotheses regarding correlations between survey items and sociodemographic associations were supported. EQ-5D summary scores were lower in respondents who were older, female, widowed/single, lower educated, and living alone. Increasing co-morbidity had a clear negative effect on EQ-5D scores. Conclusion: This study supported the construct validity of the EQ-5D across four major geriatric conditions. For older persons who are generally healthy, i.e. reporting few to no chronic conditions, the EQ-5D confers poor discriminative ability due to ceiling effects. Although the overall dataset initially suggested poor discriminative ability for the EQ-5D, such was not the case within subgroups presenting with major geriatric conditions.

AB - Background: As populations age, chronic geriatric conditions linked to progressive organ failure jeopardize health-related quality of life (HRQoL). Thus, this research assessed the validity and applicability of the EQ-5D (a common HRQoL instrument) across four major chronic geriatric conditions: hearing issues, joint damage, urinary incontinence, or dizziness with falls. Methods: The study sample comprised 25,637 community-dwelling persons aged 65 years and older residing in the Netherlands (Data source: TOPICS-MDS, www.topics-mds.eu ). Floor and ceiling effects were examined. To assess convergent validity, random effects meta-correlations (Spearman's rho) were derived between individual EQ-5D domains and related survey items. To further examine construct validity, the association between sociodemographic characteristics and EQ-5D summary scores were assessed using linear mixed models. Outcomes were compared to the overall study population as well as a 'healthy' subgroup reporting no major chronic conditions. Results: Whereas ceiling effects were observed in the overall study population and the 'healthy' subgroup, such was not the case in the geriatric condition subgroups. The majority of hypotheses regarding correlations between survey items and sociodemographic associations were supported. EQ-5D summary scores were lower in respondents who were older, female, widowed/single, lower educated, and living alone. Increasing co-morbidity had a clear negative effect on EQ-5D scores. Conclusion: This study supported the construct validity of the EQ-5D across four major geriatric conditions. For older persons who are generally healthy, i.e. reporting few to no chronic conditions, the EQ-5D confers poor discriminative ability due to ceiling effects. Although the overall dataset initially suggested poor discriminative ability for the EQ-5D, such was not the case within subgroups presenting with major geriatric conditions.

KW - Dizziness

KW - EQ-5D

KW - Hearing loss

KW - Joint diseases

KW - Quality of life

KW - Urinary incontinence

UR - http://www.scopus.com/inward/record.url?scp=85014366678&partnerID=8YFLogxK

U2 - 10.1186/s12955-017-0616-x

DO - 10.1186/s12955-017-0616-x

M3 - Article

VL - 15

JO - Health and Quality of Life Outcomes

JF - Health and Quality of Life Outcomes

SN - 1477-7525

IS - 1

M1 - 45

ER -