Measuring metacarpal cortical bone by digital x-ray radiogrammetry: a step forward?

PP Geusens, W.F. Lems

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Abstract

Changes in metacarpal cortical bone mineral density (BMD) using digital x-ray radiogrammetry were studied in patients with early rheumatoid arthritis. After 1, 2, and 5 years, large BMD losses were found: -1.7%, -2.8%, and -5.6%, respectively. Elevated erythrocyte sedimentation rate and anti-cyclic citrullinated peptide levels were independent predictors of bone loss, indicating that the largest amount of bone loss was found in patients with severe inflammation and high production of auto-antibodies, who are known to be at the highest risk of developing radiological bone damage. Studies are needed about the spatial and time relationship between erosions and juxta-articular and metacarpal bone loss
Original languageEnglish
Pages (from-to)127
Number of pages2
JournalArthritis Research & Therapy
Volume11
Issue number5
DOIs
Publication statusPublished - 2009

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