The burden of disease for depression goes beyond functioning and quality of life and extends to somatic health. Depression has shown to subsequently increase the risk of cardiovascular morbidity and mortality. These somatic consequences can be partly explained by mediating mechanisms such as unhealthy lifestyle (smoking, excessive alcohol use, physical inactivity, unhealthy diet) or unfavorable pathophysiological disturbances (metabolic, immuno-inflammatory, autonomic, and HPA-axis dysregulations). This chapter presents epidemiological evidence for the existence of these plausible underlying mechanisms that link depression to cardiovascular disease. However, alternative explanations for an increased cardiovascular risk in depressed persons are also discussed, namely, the confounding hypothesis, iatrogenic effects, or noncausal "third factors."
|Title of host publication||Cardiovascular Diseases and Depression|
|Subtitle of host publication||Treatment and Prevention in Psychocardiology|
|Editors||B. Baune, P. Tully|
|Place of Publication||Cham|
|Publisher||Springer International Publishing Switzerland|
|Number of pages||16|
|Publication status||Published - 1 Jan 2016|