Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue

Sophie N. Saxton, Ben J. Clark, Sarah B. Withers, Etto C. Eringa, Anthony M. Heagerty

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk. Adipose tissue distribution and morphology play a key role in determining the degree of adverse effects, and a key factor in the disease process appears to be the inflammatory cell population in adipose tissue. Healthy adipose tissue secretes a number of vasoactive adipokines and anti-inflammatory cytokines, and changes to this secretory profile will contribute to pathogenesis in obesity. In this review, we discuss the links between adipokine dysregulation and the development of hypertension and diabetes and explore the potential for manipulating adipose tissue morphology and its immune cell population to improve cardiovascular health in obesity.
Original languageEnglish
Pages (from-to)1701-1763
Number of pages64
JournalPhysiological Reviews
Volume99
Issue number4
DOIs
Publication statusPublished - 2019

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