Medication-related adverse events during hospitalization: a retrospective patient record review study in The Netherlands

Nikki L. Damen, Rebecca Baines, Cordula Wagner, Maaike Langelaan

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose: Medication-related adverse events (MRAEs) are an important priority for patient safety. Results from Dutch AE studies showed that—despite various improvement initiatives—the incidence of preventable MRAEs did not decline. The aim of this study is to describe the characteristics of MRAEs during hospitalizations using national patient data from records of patients admitted to Dutch hospitals in 2008 and 2011/2012. Methods: Trained nurses and physicians reviewed the randomly selected records of 8071 patients admitted to one of 20 hospitals in 2008 or 2011/2012 during a two-stage review process. Patient and admission characteristics were collected. After identification of a MRAE, physicians determined their potential preventability, drug type, related prescribing factors, and potential consequences. Results: The physicians identified 928 adverse events (AEs) in 857 admissions, of which 218 (15.2%) were medication-related. They judged 55 (18.4%) of these as preventable. Preventability of MRAEs was high in anticoagulant treatment (42.5%). Haematoma (39.0%) and intra-cerebral haemorrhage (25.5%) were common types of anticoagulant-related AEs. Anticoagulant-related AEs were often related to dosage factors (46.9%) and often resulted in an intervention (80.2%), of which 40.2% was judged as preventable. Conclusions: This study provided detailed information on MRAEs during hospital admissions in The Netherlands. A substantial proportion of AEs was medication-related (15.2%), of which 18.4% was judged to be preventable. As preventability in MRAEs was especially high in anticoagulant treatment (42.5%), those medications are a threat to patient safety. Future research and new safety programs should focus on prevention of AEs related to this medication group.

Original languageEnglish
Pages (from-to)32-39
Number of pages8
JournalPharmacoepidemiology and Drug Safety
Volume26
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

Cite this

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title = "Medication-related adverse events during hospitalization: a retrospective patient record review study in The Netherlands",
abstract = "Purpose: Medication-related adverse events (MRAEs) are an important priority for patient safety. Results from Dutch AE studies showed that—despite various improvement initiatives—the incidence of preventable MRAEs did not decline. The aim of this study is to describe the characteristics of MRAEs during hospitalizations using national patient data from records of patients admitted to Dutch hospitals in 2008 and 2011/2012. Methods: Trained nurses and physicians reviewed the randomly selected records of 8071 patients admitted to one of 20 hospitals in 2008 or 2011/2012 during a two-stage review process. Patient and admission characteristics were collected. After identification of a MRAE, physicians determined their potential preventability, drug type, related prescribing factors, and potential consequences. Results: The physicians identified 928 adverse events (AEs) in 857 admissions, of which 218 (15.2{\%}) were medication-related. They judged 55 (18.4{\%}) of these as preventable. Preventability of MRAEs was high in anticoagulant treatment (42.5{\%}). Haematoma (39.0{\%}) and intra-cerebral haemorrhage (25.5{\%}) were common types of anticoagulant-related AEs. Anticoagulant-related AEs were often related to dosage factors (46.9{\%}) and often resulted in an intervention (80.2{\%}), of which 40.2{\%} was judged as preventable. Conclusions: This study provided detailed information on MRAEs during hospital admissions in The Netherlands. A substantial proportion of AEs was medication-related (15.2{\%}), of which 18.4{\%} was judged to be preventable. As preventability in MRAEs was especially high in anticoagulant treatment (42.5{\%}), those medications are a threat to patient safety. Future research and new safety programs should focus on prevention of AEs related to this medication group.",
keywords = "adverse events, anticoagulant treatment, hospitals, medication errors, patient safety, pharmacoepidemiology, retrospective studies",
author = "Damen, {Nikki L.} and Rebecca Baines and Cordula Wagner and Maaike Langelaan",
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Medication-related adverse events during hospitalization : a retrospective patient record review study in The Netherlands. / Damen, Nikki L.; Baines, Rebecca; Wagner, Cordula; Langelaan, Maaike.

In: Pharmacoepidemiology and Drug Safety, Vol. 26, No. 1, 01.01.2017, p. 32-39.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Medication-related adverse events during hospitalization

T2 - a retrospective patient record review study in The Netherlands

AU - Damen, Nikki L.

AU - Baines, Rebecca

AU - Wagner, Cordula

AU - Langelaan, Maaike

PY - 2017/1/1

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N2 - Purpose: Medication-related adverse events (MRAEs) are an important priority for patient safety. Results from Dutch AE studies showed that—despite various improvement initiatives—the incidence of preventable MRAEs did not decline. The aim of this study is to describe the characteristics of MRAEs during hospitalizations using national patient data from records of patients admitted to Dutch hospitals in 2008 and 2011/2012. Methods: Trained nurses and physicians reviewed the randomly selected records of 8071 patients admitted to one of 20 hospitals in 2008 or 2011/2012 during a two-stage review process. Patient and admission characteristics were collected. After identification of a MRAE, physicians determined their potential preventability, drug type, related prescribing factors, and potential consequences. Results: The physicians identified 928 adverse events (AEs) in 857 admissions, of which 218 (15.2%) were medication-related. They judged 55 (18.4%) of these as preventable. Preventability of MRAEs was high in anticoagulant treatment (42.5%). Haematoma (39.0%) and intra-cerebral haemorrhage (25.5%) were common types of anticoagulant-related AEs. Anticoagulant-related AEs were often related to dosage factors (46.9%) and often resulted in an intervention (80.2%), of which 40.2% was judged as preventable. Conclusions: This study provided detailed information on MRAEs during hospital admissions in The Netherlands. A substantial proportion of AEs was medication-related (15.2%), of which 18.4% was judged to be preventable. As preventability in MRAEs was especially high in anticoagulant treatment (42.5%), those medications are a threat to patient safety. Future research and new safety programs should focus on prevention of AEs related to this medication group.

AB - Purpose: Medication-related adverse events (MRAEs) are an important priority for patient safety. Results from Dutch AE studies showed that—despite various improvement initiatives—the incidence of preventable MRAEs did not decline. The aim of this study is to describe the characteristics of MRAEs during hospitalizations using national patient data from records of patients admitted to Dutch hospitals in 2008 and 2011/2012. Methods: Trained nurses and physicians reviewed the randomly selected records of 8071 patients admitted to one of 20 hospitals in 2008 or 2011/2012 during a two-stage review process. Patient and admission characteristics were collected. After identification of a MRAE, physicians determined their potential preventability, drug type, related prescribing factors, and potential consequences. Results: The physicians identified 928 adverse events (AEs) in 857 admissions, of which 218 (15.2%) were medication-related. They judged 55 (18.4%) of these as preventable. Preventability of MRAEs was high in anticoagulant treatment (42.5%). Haematoma (39.0%) and intra-cerebral haemorrhage (25.5%) were common types of anticoagulant-related AEs. Anticoagulant-related AEs were often related to dosage factors (46.9%) and often resulted in an intervention (80.2%), of which 40.2% was judged as preventable. Conclusions: This study provided detailed information on MRAEs during hospital admissions in The Netherlands. A substantial proportion of AEs was medication-related (15.2%), of which 18.4% was judged to be preventable. As preventability in MRAEs was especially high in anticoagulant treatment (42.5%), those medications are a threat to patient safety. Future research and new safety programs should focus on prevention of AEs related to this medication group.

KW - adverse events

KW - anticoagulant treatment

KW - hospitals

KW - medication errors

KW - patient safety

KW - pharmacoepidemiology

KW - retrospective studies

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DO - 10.1002/pds.4037

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