Abstract

Background: Medication use during pregnancy and lactation can be unavoidable, but knowledge on safety for the fetus or breastfed infant is limited among patients and healthcare providers. Research aim: This study aimed to determine (a) the prevalence of medication use in pregnant and lactating women in a tertiary academic center, (b) the types and safety of these medicines, and (c) the influence of medication use on initiation of breastfeeding. Methods: This study used a cross-sectional survey among women (N = 292) who underwent high-risk or low-risk deliveries. Data about their use of prescribed, over-the-counter, and homeopathic medication during pregnancy were obtained through a structured interview, followed by a questionnaire during lactation. Safety was classified according to the risk classification system from the Dutch Teratological Information Service. Results: Overall, 95.5% of participants used medication. One third of participants used at least one medicine with an unknown risk for the fetus. Teratogenic medication was used by 6.5% of participants, whereas 29.5% used medication with a (suspected) pharmacological effect on the fetus. Lactation was initiated by 258 (88.7%) participants, of which 84.2% used medication while breastfeeding. In 3.8% of participants, this medication was classified unsafe, but none used medication with an unknown risk. One-third of the nonlactating participants decided not to initiate breastfeeding because of medication use. In 70% of participants, this decision was appropriate. Conclusion: The prevalence of overall use of medication in Dutch pregnant and lactating women admitted to a tertiary center was high. There is an urgent need for pharmacometric studies for determination of the safe use of the most frequently used medicines during pregnancy or lactation.
Original languageEnglish
Pages (from-to)154-164
Number of pages11
JournalJournal of Human Lactation
Volume35
Issue number1
Early online date1 Jun 2018
DOIs
Publication statusPublished - 1 Feb 2019

Cite this

@article{58df7f642305438e9678b23565b75f18,
title = "Medication Use During Pregnancy and Lactation in a Dutch Population",
abstract = "Background: Medication use during pregnancy and lactation can be unavoidable, but knowledge on safety for the fetus or breastfed infant is limited among patients and healthcare providers. Research aim: This study aimed to determine (a) the prevalence of medication use in pregnant and lactating women in a tertiary academic center, (b) the types and safety of these medicines, and (c) the influence of medication use on initiation of breastfeeding. Methods: This study used a cross-sectional survey among women (N = 292) who underwent high-risk or low-risk deliveries. Data about their use of prescribed, over-the-counter, and homeopathic medication during pregnancy were obtained through a structured interview, followed by a questionnaire during lactation. Safety was classified according to the risk classification system from the Dutch Teratological Information Service. Results: Overall, 95.5{\%} of participants used medication. One third of participants used at least one medicine with an unknown risk for the fetus. Teratogenic medication was used by 6.5{\%} of participants, whereas 29.5{\%} used medication with a (suspected) pharmacological effect on the fetus. Lactation was initiated by 258 (88.7{\%}) participants, of which 84.2{\%} used medication while breastfeeding. In 3.8{\%} of participants, this medication was classified unsafe, but none used medication with an unknown risk. One-third of the nonlactating participants decided not to initiate breastfeeding because of medication use. In 70{\%} of participants, this decision was appropriate. Conclusion: The prevalence of overall use of medication in Dutch pregnant and lactating women admitted to a tertiary center was high. There is an urgent need for pharmacometric studies for determination of the safe use of the most frequently used medicines during pregnancy or lactation.",
author = "{de Waard}, Marita and Blomjous, {Birgit S.} and Hol, {Marinka L. F.} and Sie, {Sintha D.} and Corpeleijn, {Willemijn E.} and {van Goudoever}, {Johannes (Hans) B.} and {van Weissenbruch}, {Mirjam M.}",
year = "2019",
month = "2",
day = "1",
doi = "10.1177/0890334418775630",
language = "English",
volume = "35",
pages = "154--164",
journal = "Journal of Human Lactation",
issn = "0890-3344",
publisher = "SAGE Publications Inc.",
number = "1",

}

Medication Use During Pregnancy and Lactation in a Dutch Population. / de Waard, Marita; Blomjous, Birgit S.; Hol, Marinka L. F.; Sie, Sintha D.; Corpeleijn, Willemijn E.; van Goudoever, Johannes (Hans) B.; van Weissenbruch, Mirjam M.

In: Journal of Human Lactation, Vol. 35, No. 1, 01.02.2019, p. 154-164.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Medication Use During Pregnancy and Lactation in a Dutch Population

AU - de Waard, Marita

AU - Blomjous, Birgit S.

AU - Hol, Marinka L. F.

AU - Sie, Sintha D.

AU - Corpeleijn, Willemijn E.

AU - van Goudoever, Johannes (Hans) B.

AU - van Weissenbruch, Mirjam M.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Background: Medication use during pregnancy and lactation can be unavoidable, but knowledge on safety for the fetus or breastfed infant is limited among patients and healthcare providers. Research aim: This study aimed to determine (a) the prevalence of medication use in pregnant and lactating women in a tertiary academic center, (b) the types and safety of these medicines, and (c) the influence of medication use on initiation of breastfeeding. Methods: This study used a cross-sectional survey among women (N = 292) who underwent high-risk or low-risk deliveries. Data about their use of prescribed, over-the-counter, and homeopathic medication during pregnancy were obtained through a structured interview, followed by a questionnaire during lactation. Safety was classified according to the risk classification system from the Dutch Teratological Information Service. Results: Overall, 95.5% of participants used medication. One third of participants used at least one medicine with an unknown risk for the fetus. Teratogenic medication was used by 6.5% of participants, whereas 29.5% used medication with a (suspected) pharmacological effect on the fetus. Lactation was initiated by 258 (88.7%) participants, of which 84.2% used medication while breastfeeding. In 3.8% of participants, this medication was classified unsafe, but none used medication with an unknown risk. One-third of the nonlactating participants decided not to initiate breastfeeding because of medication use. In 70% of participants, this decision was appropriate. Conclusion: The prevalence of overall use of medication in Dutch pregnant and lactating women admitted to a tertiary center was high. There is an urgent need for pharmacometric studies for determination of the safe use of the most frequently used medicines during pregnancy or lactation.

AB - Background: Medication use during pregnancy and lactation can be unavoidable, but knowledge on safety for the fetus or breastfed infant is limited among patients and healthcare providers. Research aim: This study aimed to determine (a) the prevalence of medication use in pregnant and lactating women in a tertiary academic center, (b) the types and safety of these medicines, and (c) the influence of medication use on initiation of breastfeeding. Methods: This study used a cross-sectional survey among women (N = 292) who underwent high-risk or low-risk deliveries. Data about their use of prescribed, over-the-counter, and homeopathic medication during pregnancy were obtained through a structured interview, followed by a questionnaire during lactation. Safety was classified according to the risk classification system from the Dutch Teratological Information Service. Results: Overall, 95.5% of participants used medication. One third of participants used at least one medicine with an unknown risk for the fetus. Teratogenic medication was used by 6.5% of participants, whereas 29.5% used medication with a (suspected) pharmacological effect on the fetus. Lactation was initiated by 258 (88.7%) participants, of which 84.2% used medication while breastfeeding. In 3.8% of participants, this medication was classified unsafe, but none used medication with an unknown risk. One-third of the nonlactating participants decided not to initiate breastfeeding because of medication use. In 70% of participants, this decision was appropriate. Conclusion: The prevalence of overall use of medication in Dutch pregnant and lactating women admitted to a tertiary center was high. There is an urgent need for pharmacometric studies for determination of the safe use of the most frequently used medicines during pregnancy or lactation.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/29969343

U2 - 10.1177/0890334418775630

DO - 10.1177/0890334418775630

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SP - 154

EP - 164

JO - Journal of Human Lactation

JF - Journal of Human Lactation

SN - 0890-3344

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