Abstract
Original language | English |
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Pages (from-to) | 170-182 |
Journal | Behavior Genetics |
Volume | 46 |
Issue number | 2 |
DOIs | |
Publication status | Published - Mar 2016 |
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Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium. / van den Berg, Stephanie M.; de Moor, Marleen H. M.; Verweij, Karin J. H.; Krueger, Robert F.; Luciano, Michelle; Vasquez, Alejandro Arias; Matteson, Lindsay K.; Derringer, Jaime; Esko, Tonu; Amin, Najaf; Gordon, Scott D.; Hansell, Narelle K.; Hart, Amy B.; Seppala, Ilkka; Huffman, Jennifer E.; Konte, Bettina; Lahti, Jari; Lee, Minyoung; Miller, Mike; Nutile, Teresa; Tanaka, Toshiko; Teumer, Alexander; Viktorin, Alexander; Wedenoja, Juho; Abdellaoui, Abdel; Abecasis, Goncalo R.; Adkins, Daniel E.; Agrawal, Arpana; Allik, Jueri; Appel, Katja; Bigdeli, Timothy B.; Busonero, Fabio; Campbell, Harry; Costa, Paul T.; Smith, George Davey; Davies, Gail; de Wit, Harriet; Ding, Jun; Engelhardt, Barbara E.; Eriksson, Johan G.; Fedko, Iryna O.; Ferrucci, Luigi; Franke, Barbara; Giegling, Ina; Grucza, Richard; Hartmann, Annette M.; Heath, Andrew C.; Heinonen, Kati; Henders, Anjali K.; Homuth, Georg; Hottenga, Jouke-Jan; Iacono, William G.; Janzing, Joost; Jokela, Markus; Karlsson, Robert; Kemp, John P.; Kirkpatrick, Matthew G.; Latvala, Antti; Lehtimaki, Terho; Liewald, David C.; Madden, Pamela A. F.; Magri, Chiara; Magnusson, Patrik K. E.; Marten, Jonathan; Maschio, Andrea; Mbarek, Hamdi; Medland, Sarah E.; Mihailov, Evelin; Milaneschi, Yuri; Montgomery, Grant W.; Nauck, Matthias; Nivard, Michel G.; Ouwens, Klaasjan G.; Palotie, Aarno; Pettersson, Erik; Polasek, Ozren; Qian, Yong; Pulkki-Raback, Laura; Raitakari, Olli T.; Realo, Anu; Rose, Richard J.; Ruggiero, Daniela; Schmidt, Carsten O.; Slutske, Wendy S.; Sorice, Rossella; Starr, John M.; St Pourcain, Beate; Sutin, Angelina R.; Timpson, Nicholas J.; Trochet, Holly; Vermeulen, Sita; Vuoksimaa, Eero; Widen, Elisabeth; Wouda, Jasper; Wright, Margaret J.; Zgaga, Lina; Porteous, David; Minelli, Alessandra; Palmer, Abraham A.; Rujescu, Dan; Ciullo, Marina; Hayward, Caroline; Rudan, Igor; Metspalu, Andres; Kaprio, Jaakko; Deary, Ian J.; Raikkonen, Katri; Wilson, James F.; Keltikangas-Jarvinen, Liisa; Bierut, Laura J.; Hettema, John M.; Grabe, Hans J.; Penninx, Brenda W. J. H.; van Duijn, Cornelia M.; Evans, David M.; Schlessinger, David; Pedersen, Nancy L.; Terracciano, Antonio; McGue, Matt; Martin, Nicholas G.; Boomsma, Dorret I.
In: Behavior Genetics, Vol. 46, No. 2, 03.2016, p. 170-182.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium
AU - van den Berg, Stephanie M.
AU - de Moor, Marleen H. M.
AU - Verweij, Karin J. H.
AU - Krueger, Robert F.
AU - Luciano, Michelle
AU - Vasquez, Alejandro Arias
AU - Matteson, Lindsay K.
AU - Derringer, Jaime
AU - Esko, Tonu
AU - Amin, Najaf
AU - Gordon, Scott D.
AU - Hansell, Narelle K.
AU - Hart, Amy B.
AU - Seppala, Ilkka
AU - Huffman, Jennifer E.
AU - Konte, Bettina
AU - Lahti, Jari
AU - Lee, Minyoung
AU - Miller, Mike
AU - Nutile, Teresa
AU - Tanaka, Toshiko
AU - Teumer, Alexander
AU - Viktorin, Alexander
AU - Wedenoja, Juho
AU - Abdellaoui, Abdel
AU - Abecasis, Goncalo R.
AU - Adkins, Daniel E.
AU - Agrawal, Arpana
AU - Allik, Jueri
AU - Appel, Katja
AU - Bigdeli, Timothy B.
AU - Busonero, Fabio
AU - Campbell, Harry
AU - Costa, Paul T.
AU - Smith, George Davey
AU - Davies, Gail
AU - de Wit, Harriet
AU - Ding, Jun
AU - Engelhardt, Barbara E.
AU - Eriksson, Johan G.
AU - Fedko, Iryna O.
AU - Ferrucci, Luigi
AU - Franke, Barbara
AU - Giegling, Ina
AU - Grucza, Richard
AU - Hartmann, Annette M.
AU - Heath, Andrew C.
AU - Heinonen, Kati
AU - Henders, Anjali K.
AU - Homuth, Georg
AU - Hottenga, Jouke-Jan
AU - Iacono, William G.
AU - Janzing, Joost
AU - Jokela, Markus
AU - Karlsson, Robert
AU - Kemp, John P.
AU - Kirkpatrick, Matthew G.
AU - Latvala, Antti
AU - Lehtimaki, Terho
AU - Liewald, David C.
AU - Madden, Pamela A. F.
AU - Magri, Chiara
AU - Magnusson, Patrik K. E.
AU - Marten, Jonathan
AU - Maschio, Andrea
AU - Mbarek, Hamdi
AU - Medland, Sarah E.
AU - Mihailov, Evelin
AU - Milaneschi, Yuri
AU - Montgomery, Grant W.
AU - Nauck, Matthias
AU - Nivard, Michel G.
AU - Ouwens, Klaasjan G.
AU - Palotie, Aarno
AU - Pettersson, Erik
AU - Polasek, Ozren
AU - Qian, Yong
AU - Pulkki-Raback, Laura
AU - Raitakari, Olli T.
AU - Realo, Anu
AU - Rose, Richard J.
AU - Ruggiero, Daniela
AU - Schmidt, Carsten O.
AU - Slutske, Wendy S.
AU - Sorice, Rossella
AU - Starr, John M.
AU - St Pourcain, Beate
AU - Sutin, Angelina R.
AU - Timpson, Nicholas J.
AU - Trochet, Holly
AU - Vermeulen, Sita
AU - Vuoksimaa, Eero
AU - Widen, Elisabeth
AU - Wouda, Jasper
AU - Wright, Margaret J.
AU - Zgaga, Lina
AU - Porteous, David
AU - Minelli, Alessandra
AU - Palmer, Abraham A.
AU - Rujescu, Dan
AU - Ciullo, Marina
AU - Hayward, Caroline
AU - Rudan, Igor
AU - Metspalu, Andres
AU - Kaprio, Jaakko
AU - Deary, Ian J.
AU - Raikkonen, Katri
AU - Wilson, James F.
AU - Keltikangas-Jarvinen, Liisa
AU - Bierut, Laura J.
AU - Hettema, John M.
AU - Grabe, Hans J.
AU - Penninx, Brenda W. J. H.
AU - van Duijn, Cornelia M.
AU - Evans, David M.
AU - Schlessinger, David
AU - Pedersen, Nancy L.
AU - Terracciano, Antonio
AU - McGue, Matt
AU - Martin, Nicholas G.
AU - Boomsma, Dorret I.
PY - 2016/3
Y1 - 2016/3
N2 - Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion.
AB - Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion.
KW - Personality
KW - Phenotype harmonization
KW - Common genetic variants
KW - Imputation
KW - Polygenic risk
U2 - 10.1007/s10519-015-9735-5
DO - 10.1007/s10519-015-9735-5
M3 - Article
C2 - 26362575
VL - 46
SP - 170
EP - 182
JO - Behavior Genetics
JF - Behavior Genetics
SN - 0001-8244
IS - 2
ER -