Metabolic patterns across core features in dementia with lewy bodies

Silvia Morbelli, Andrea Chincarini, Matthias Brendel, Axel Rominger, Rose Bruffaerts, Rik Vandenberghe, Milica G. Kramberger, Maja Trost, Valentina Garibotto, Nicolas Nicastro, Giovanni B. Frisoni, Afina W. Lemstra, Jessica van der Zande, Andrea Pilotto, Alessandro Padovani, Sara Garcia-Ptacek, Irina Savitcheva, Miguel A. Ochoa-Figueroa, Annette Davidsson, Valle CamachoEnrico Peira, Dario Arnaldi, Matteo Bauckneht, Matteo Pardini, Gianmario Sambuceti, Dag Aarsland, Flavio Nobili

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: To identify brain regions whose metabolic impairment contributes to dementia with Lewy bodies (DLB) clinical core features expression and to assess the influence of severity of global cognitive impairment on the DLB hypometabolic pattern. Methods: Brain fluorodeoxyglucose positron emission tomography and information on core features were available in 171 patients belonging to the imaging repository of the European DLB Consortium. Principal component analysis was applied to identify brain regions relevant to the local data variance. A linear regression model was applied to generate core-feature–specific patterns controlling for the main confounding variables (Mini-Mental State Examination [MMSE], age, education, gender, and center). Regression analysis to the locally normalized intensities was performed to generate an MMSE-sensitive map. Results: Parkinsonism negatively covaried with bilateral parietal, precuneus, and anterior cingulate metabolism; visual hallucinations (VH) with bilateral dorsolateral–frontal cortex, posterior cingulate, and parietal metabolism; and rapid eye movement sleep behavior disorder (RBD) with bilateral parieto-occipital cortex, precuneus, and ventrolateral–frontal metabolism. VH and RBD shared a positive covariance with metabolism in the medial temporal lobe, cerebellum, brainstem, basal ganglia, thalami, and orbitofrontal and sensorimotor cortex. Cognitive fluctuations negatively covaried with occipital metabolism and positively with parietal lobe metabolism. MMSE positively covaried with metabolism in the left superior frontal gyrus, bilateral–parietal cortex, and left precuneus, and negatively with metabolism in the insula, medial frontal gyrus, hippocampus in the left hemisphere, and right cerebellum. Interpretation: Regions of more preserved metabolism are relatively consistent across the variegate DLB spectrum. By contrast, core features were associated with more prominent hypometabolism in specific regions, thus suggesting a close clinical–imaging correlation, reflecting the interplay between topography of neurodegeneration and clinical presentation in DLB patients. Ann Neurol 2019;85:715–725.

Original languageEnglish
Pages (from-to)715-725
Number of pages11
JournalAnnals of Neurology
Volume85
Issue number5
DOIs
Publication statusPublished - 1 May 2019

Cite this

Morbelli, S., Chincarini, A., Brendel, M., Rominger, A., Bruffaerts, R., Vandenberghe, R., ... Nobili, F. (2019). Metabolic patterns across core features in dementia with lewy bodies. Annals of Neurology, 85(5), 715-725. https://doi.org/10.1002/ana.25453