Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 614-619 |
| Journal | Biological Psychiatry |
| Volume | 65 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2009 |
| Externally published | Yes |
Cite this
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Methylphenidate Restores Link Between Stop-Signal Sensory Impact and Successful Stopping in Adults with Attention-Deficit/Hyperactivity Disorder. / Overtoom, Carin C. E.; Bekker, Evelijne M.; van der Molen, Maurits W.; Verbaten, Marinus N.; Kooij, J. J. Sandra; Buitelaar, Jan K.; Kenemans, J. Leon.
In: Biological Psychiatry, Vol. 65, No. 7, 2009, p. 614-619.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Methylphenidate Restores Link Between Stop-Signal Sensory Impact and Successful Stopping in Adults with Attention-Deficit/Hyperactivity Disorder
AU - Overtoom, Carin C. E.
AU - Bekker, Evelijne M.
AU - van der Molen, Maurits W.
AU - Verbaten, Marinus N.
AU - Kooij, J. J. Sandra
AU - Buitelaar, Jan K.
AU - Kenemans, J. Leon
PY - 2009
Y1 - 2009
N2 - Background: The ability to revise one's action plans, as reflected in so-called stopping performance, is of fundamental importance to adaptive behavior. Previous studies in children and adults with attention-deficit/hyperactivity disorder (ADHD) have revealed impaired stopping, which improved after the administration of methylphenidate (MPH). Event-related brain potentials revealed that one crucial mechanism in adequate stopping is the link between the cortical areas that process the signal to stop and the motor system (stop N1). This stop N1 was severely compromised in adults with ADHD. The present study investigates whether methylphenidate can restore the stop N1, in addition to improving stopping performance. The acute effect of a serotonergic reuptake inhibition on these parameters was also assessed. Methods: Twelve adult combined-type ADHD patients received either placebo, MPH .4 mg/kg or .6 mg/kg, or 20 mg paroxetine in a double-blind, randomized, within-subjects design. Results: The .6 mg/kg dose of methylphenidate improved stopping performance, whereas it did not affect go reaction time (RT). It also restored the stop N1 that was absent under placebo. Methylphenidate reduced a later stop-related potential, the stop P3, which may reflect monitoring of failed stops. Paroxetine had no effect on stopping performance or on stop N1, but it reduced stop P3. Conclusions: A .6 mg/kg dose of methylphenidate improves stopping performance and directly targets a stop-related brain mechanism that has been reported before to be compromised in a group of ADHD patients. This mechanism was not influenced by acute serotonergic reuptake inhibition. © 2009 Society of Biological Psychiatry.
AB - Background: The ability to revise one's action plans, as reflected in so-called stopping performance, is of fundamental importance to adaptive behavior. Previous studies in children and adults with attention-deficit/hyperactivity disorder (ADHD) have revealed impaired stopping, which improved after the administration of methylphenidate (MPH). Event-related brain potentials revealed that one crucial mechanism in adequate stopping is the link between the cortical areas that process the signal to stop and the motor system (stop N1). This stop N1 was severely compromised in adults with ADHD. The present study investigates whether methylphenidate can restore the stop N1, in addition to improving stopping performance. The acute effect of a serotonergic reuptake inhibition on these parameters was also assessed. Methods: Twelve adult combined-type ADHD patients received either placebo, MPH .4 mg/kg or .6 mg/kg, or 20 mg paroxetine in a double-blind, randomized, within-subjects design. Results: The .6 mg/kg dose of methylphenidate improved stopping performance, whereas it did not affect go reaction time (RT). It also restored the stop N1 that was absent under placebo. Methylphenidate reduced a later stop-related potential, the stop P3, which may reflect monitoring of failed stops. Paroxetine had no effect on stopping performance or on stop N1, but it reduced stop P3. Conclusions: A .6 mg/kg dose of methylphenidate improves stopping performance and directly targets a stop-related brain mechanism that has been reported before to be compromised in a group of ADHD patients. This mechanism was not influenced by acute serotonergic reuptake inhibition. © 2009 Society of Biological Psychiatry.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=61549092485&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/19103443
U2 - 10.1016/j.biopsych.2008.10.048
DO - 10.1016/j.biopsych.2008.10.048
M3 - Article
VL - 65
SP - 614
EP - 619
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 7
ER -