Methylphenidate significantly improves declarative memory functioning of adults with ADHD

Joris C. Verster, Evelijne M. Bekker, J. J. Sandra Kooij, Jan K. Buitelaar, Marinus N. Verbaten, Edmund R. Volkerts, Berend Olivier

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Declarative memory deficits are common in untreated adults with attention-deficit hyperactivity disorder (ADHD), but limited evidence exists to support improvement after treatment with methylphenidate. The objective of this study was to examine the effects of methylphenidate on memory functioning of adults with ADHD. Methods: Eighteen adults with ADHD who were clinical responders to methylphenidate participated in this randomized crossover trial. After 3 days of no treatment, patients received in random order either their usual methylphenidate dose (mean: 14.7 mg; range: 10-30 mg) or placebo, separated by a 6-7-day washout period. Patients performed an immediate word recall test 1 h after treatment administration. Three hours after intake, patients performed the second part of the memory test (delayed word recall and a recognition test). Results: Delayed recognition and immediate recall was similar on treatment and on placebo. Delayed word recall was significantly better in the methylphenidate than in the placebo condition (F 1, 17∈=∈7.0, p∈<∈0.017). A significant correlation was found between prestudy CES-D depression scores and difference scores on delayed recall (r∈=∈0.602, p∈<∈0.008). Conclusion: Methylphenidate improves declarative memory functioning in patients with ADHD. New studies should further examine whether subclinical depressive symptoms mediate the effect of methylphenidate on declarative memory. © 2010 The Author(s).
Original languageEnglish
Pages (from-to)277-281
JournalPsychopharmacology
Volume212
Issue number2
DOIs
Publication statusPublished - 2010
Externally publishedYes

Cite this

Verster, J. C., Bekker, E. M., Kooij, J. J. S., Buitelaar, J. K., Verbaten, M. N., Volkerts, E. R., & Olivier, B. (2010). Methylphenidate significantly improves declarative memory functioning of adults with ADHD. Psychopharmacology, 212(2), 277-281. https://doi.org/10.1007/s00213-010-1952-2
Verster, Joris C. ; Bekker, Evelijne M. ; Kooij, J. J. Sandra ; Buitelaar, Jan K. ; Verbaten, Marinus N. ; Volkerts, Edmund R. ; Olivier, Berend. / Methylphenidate significantly improves declarative memory functioning of adults with ADHD. In: Psychopharmacology. 2010 ; Vol. 212, No. 2. pp. 277-281.
@article{5f86e1c97b2044e19f151179a5a288f7,
title = "Methylphenidate significantly improves declarative memory functioning of adults with ADHD",
abstract = "Background: Declarative memory deficits are common in untreated adults with attention-deficit hyperactivity disorder (ADHD), but limited evidence exists to support improvement after treatment with methylphenidate. The objective of this study was to examine the effects of methylphenidate on memory functioning of adults with ADHD. Methods: Eighteen adults with ADHD who were clinical responders to methylphenidate participated in this randomized crossover trial. After 3 days of no treatment, patients received in random order either their usual methylphenidate dose (mean: 14.7 mg; range: 10-30 mg) or placebo, separated by a 6-7-day washout period. Patients performed an immediate word recall test 1 h after treatment administration. Three hours after intake, patients performed the second part of the memory test (delayed word recall and a recognition test). Results: Delayed recognition and immediate recall was similar on treatment and on placebo. Delayed word recall was significantly better in the methylphenidate than in the placebo condition (F 1, 17∈=∈7.0, p∈<∈0.017). A significant correlation was found between prestudy CES-D depression scores and difference scores on delayed recall (r∈=∈0.602, p∈<∈0.008). Conclusion: Methylphenidate improves declarative memory functioning in patients with ADHD. New studies should further examine whether subclinical depressive symptoms mediate the effect of methylphenidate on declarative memory. {\circledC} 2010 The Author(s).",
author = "Verster, {Joris C.} and Bekker, {Evelijne M.} and Kooij, {J. J. Sandra} and Buitelaar, {Jan K.} and Verbaten, {Marinus N.} and Volkerts, {Edmund R.} and Berend Olivier",
year = "2010",
doi = "10.1007/s00213-010-1952-2",
language = "English",
volume = "212",
pages = "277--281",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "2",

}

Verster, JC, Bekker, EM, Kooij, JJS, Buitelaar, JK, Verbaten, MN, Volkerts, ER & Olivier, B 2010, 'Methylphenidate significantly improves declarative memory functioning of adults with ADHD' Psychopharmacology, vol. 212, no. 2, pp. 277-281. https://doi.org/10.1007/s00213-010-1952-2

Methylphenidate significantly improves declarative memory functioning of adults with ADHD. / Verster, Joris C.; Bekker, Evelijne M.; Kooij, J. J. Sandra; Buitelaar, Jan K.; Verbaten, Marinus N.; Volkerts, Edmund R.; Olivier, Berend.

In: Psychopharmacology, Vol. 212, No. 2, 2010, p. 277-281.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Methylphenidate significantly improves declarative memory functioning of adults with ADHD

AU - Verster, Joris C.

AU - Bekker, Evelijne M.

AU - Kooij, J. J. Sandra

AU - Buitelaar, Jan K.

AU - Verbaten, Marinus N.

AU - Volkerts, Edmund R.

AU - Olivier, Berend

PY - 2010

Y1 - 2010

N2 - Background: Declarative memory deficits are common in untreated adults with attention-deficit hyperactivity disorder (ADHD), but limited evidence exists to support improvement after treatment with methylphenidate. The objective of this study was to examine the effects of methylphenidate on memory functioning of adults with ADHD. Methods: Eighteen adults with ADHD who were clinical responders to methylphenidate participated in this randomized crossover trial. After 3 days of no treatment, patients received in random order either their usual methylphenidate dose (mean: 14.7 mg; range: 10-30 mg) or placebo, separated by a 6-7-day washout period. Patients performed an immediate word recall test 1 h after treatment administration. Three hours after intake, patients performed the second part of the memory test (delayed word recall and a recognition test). Results: Delayed recognition and immediate recall was similar on treatment and on placebo. Delayed word recall was significantly better in the methylphenidate than in the placebo condition (F 1, 17∈=∈7.0, p∈<∈0.017). A significant correlation was found between prestudy CES-D depression scores and difference scores on delayed recall (r∈=∈0.602, p∈<∈0.008). Conclusion: Methylphenidate improves declarative memory functioning in patients with ADHD. New studies should further examine whether subclinical depressive symptoms mediate the effect of methylphenidate on declarative memory. © 2010 The Author(s).

AB - Background: Declarative memory deficits are common in untreated adults with attention-deficit hyperactivity disorder (ADHD), but limited evidence exists to support improvement after treatment with methylphenidate. The objective of this study was to examine the effects of methylphenidate on memory functioning of adults with ADHD. Methods: Eighteen adults with ADHD who were clinical responders to methylphenidate participated in this randomized crossover trial. After 3 days of no treatment, patients received in random order either their usual methylphenidate dose (mean: 14.7 mg; range: 10-30 mg) or placebo, separated by a 6-7-day washout period. Patients performed an immediate word recall test 1 h after treatment administration. Three hours after intake, patients performed the second part of the memory test (delayed word recall and a recognition test). Results: Delayed recognition and immediate recall was similar on treatment and on placebo. Delayed word recall was significantly better in the methylphenidate than in the placebo condition (F 1, 17∈=∈7.0, p∈<∈0.017). A significant correlation was found between prestudy CES-D depression scores and difference scores on delayed recall (r∈=∈0.602, p∈<∈0.008). Conclusion: Methylphenidate improves declarative memory functioning in patients with ADHD. New studies should further examine whether subclinical depressive symptoms mediate the effect of methylphenidate on declarative memory. © 2010 The Author(s).

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77957376765&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/20645078

U2 - 10.1007/s00213-010-1952-2

DO - 10.1007/s00213-010-1952-2

M3 - Article

VL - 212

SP - 277

EP - 281

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 2

ER -