Mevastatin increases eNO synthase expression and inhibits lipid peroxidation in human endothelial cells

Casper G. Schalkwijk*, Bastiaan Van Dam, Coen D.A. Stehouwer, Victor W.M. Van Hinsbergh

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Statins can protect endothelial activation independent from their lipid-lowering effects. To gain more insight in mechanisms via which HMG-CoA inhibition may attenuate endothelial activation, we assessed the effects of mevastatin on eNOS expression of non- and modified-LDL treated endothelial cells and on basal and hydrogen peroxide-induced lipid peroxidation. Oxidized-LDL (Ox-LDL), but not glycated or acylated LDL decreased eNOS expression in human endothelial cells. The extent to which Ox-LDL decreases eNOS expression depends on the extent of modification of Ox-LDL. Mevastatin increased eNOS-expression, both in the presence and absence of Ox-LDL. In addition, mevastatin decreased the H2O2-induced (100 μM) lipid peroxidation in endothelial cells. This study shows that mevastatin has protective effects on endothelial cells by inducing eNOS and by inhibiting lipid peroxidation.

Original languageEnglish
Pages (from-to)179-184
Number of pages6
JournalClinical Hemorheology and Microcirculation
Volume37
Issue number1-2
Publication statusPublished - 6 Jul 2007

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