Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family

J. M. Rozemuller; P. Eikelenboom; S. T. Pals; F. C. Stam

doi:10.1016/0304-3940(89)90547-8

Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family

J. M. Rozemuller^*, P. Eikelenboom, S. T. Pals, F. C. Stam

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Immunostaining for glycoproteins of the LFA-1 family (leucocyte function-associated antigens) was demonstrated on cells in the corona around senile plaques in Alzheimer's disease (AD) and in small glial cells in the subcortex of patients with AD and controls. These cells, which are usually referred to as microglial cells, showed positive immunohistochemical staining with monoclonal antibodies directed against the α-chains of all 3 LFA-1 family members, i.e. LFA-1, iC3b-receptor and P150,95, as well as with a monoclonal antibody against the common β-chain. In the corona a diffuse staining for a ligand of LFA-1, intercellular adhesion molecule (ICAM)-1, was found as well. It is suggested that these molecules of the LFA-1 family may have a function in the dynamics of neuritic degeneration and sprouting.

Original language	English
Pages (from-to)	288-292
Number of pages	5
Journal	Neuroscience Letters
Volume	101
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(89)90547-8
Publication status	Published - 3 Jul 1989

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title = "Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family",

abstract = "Immunostaining for glycoproteins of the LFA-1 family (leucocyte function-associated antigens) was demonstrated on cells in the corona around senile plaques in Alzheimer's disease (AD) and in small glial cells in the subcortex of patients with AD and controls. These cells, which are usually referred to as microglial cells, showed positive immunohistochemical staining with monoclonal antibodies directed against the α-chains of all 3 LFA-1 family members, i.e. LFA-1, iC3b-receptor and P150,95, as well as with a monoclonal antibody against the common β-chain. In the corona a diffuse staining for a ligand of LFA-1, intercellular adhesion molecule (ICAM)-1, was found as well. It is suggested that these molecules of the LFA-1 family may have a function in the dynamics of neuritic degeneration and sprouting.",

keywords = "Alzheimer's disease, Integrin, Leucocyte adhesion molecule, Microglial cell",

author = "Rozemuller, {J. M.} and P. Eikelenboom and Pals, {S. T.} and Stam, {F. C.}",

year = "1989",

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doi = "10.1016/0304-3940(89)90547-8",

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T1 - Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family

AU - Rozemuller, J. M.

AU - Eikelenboom, P.

AU - Pals, S. T.

AU - Stam, F. C.

PY - 1989/7/3

Y1 - 1989/7/3

N2 - Immunostaining for glycoproteins of the LFA-1 family (leucocyte function-associated antigens) was demonstrated on cells in the corona around senile plaques in Alzheimer's disease (AD) and in small glial cells in the subcortex of patients with AD and controls. These cells, which are usually referred to as microglial cells, showed positive immunohistochemical staining with monoclonal antibodies directed against the α-chains of all 3 LFA-1 family members, i.e. LFA-1, iC3b-receptor and P150,95, as well as with a monoclonal antibody against the common β-chain. In the corona a diffuse staining for a ligand of LFA-1, intercellular adhesion molecule (ICAM)-1, was found as well. It is suggested that these molecules of the LFA-1 family may have a function in the dynamics of neuritic degeneration and sprouting.

AB - Immunostaining for glycoproteins of the LFA-1 family (leucocyte function-associated antigens) was demonstrated on cells in the corona around senile plaques in Alzheimer's disease (AD) and in small glial cells in the subcortex of patients with AD and controls. These cells, which are usually referred to as microglial cells, showed positive immunohistochemical staining with monoclonal antibodies directed against the α-chains of all 3 LFA-1 family members, i.e. LFA-1, iC3b-receptor and P150,95, as well as with a monoclonal antibody against the common β-chain. In the corona a diffuse staining for a ligand of LFA-1, intercellular adhesion molecule (ICAM)-1, was found as well. It is suggested that these molecules of the LFA-1 family may have a function in the dynamics of neuritic degeneration and sprouting.

KW - Alzheimer's disease

KW - Integrin

KW - Leucocyte adhesion molecule

KW - Microglial cell

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JF - Neuroscience Letters

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ER -

Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family

Abstract

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