Microvascular dysfunction in obesity: A potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension

Amy M. Jonk*, Alfons J.H.M. Houben, Renate T. De Jongh, Erik H. Serné, Nicoloaas C. Schaper, Coen D.A. Stehouwer

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Obesity is an important risk factor for insulin resistance and hypertension and plays a central role in the metabolic syndrome. Insight into the pathophysiology of this syndrome may lead to new treatments. This paper has reviewed the evidence for an important role for the microcirculation as a possible link between obesity, insulin resistance and hypertension.

Original languageEnglish
Pages (from-to)252-260
Number of pages9
JournalPhysiology
Volume22
Issue number4
DOIs
Publication statusPublished - 1 Aug 2007

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