Microvascular dysfunction: Potential role in the pathogenesis of obesity-associated hypertension and insulin resistance

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

The intertwined epidemics of obesity and related disorders such as hypertension, insulin resistance, type 2 diabetes, and subsequent cardiovascular disease pose a major public health challenge. To meet this challenge, we must understand the interplay between adipose tissue and the vasculature. Microvascular dysfunction is important not only in the development of obesityrelated target-organ damage, but also in the development of cardiovascular risk factors such as hypertension and insulin resistance. The present chapter examines the role of microvascular dysfunction as an explanation for the associations among obesity, hypertension and impaired insulin-mediated glucose disposal. We also discuss communicative pathways from adipose tissue to the microcirculation.

Original languageEnglish
Title of host publicationMicrocirculation and Insulin Resistance
PublisherBentham Science Publishers Ltd.
Pages41-54
Number of pages14
ISBN (Print)9781608056835
DOIs
Publication statusPublished - 1 Dec 2009

Cite this

@inbook{58189f38fdc34f938ac8f3fc733e6bbe,
title = "Microvascular dysfunction: Potential role in the pathogenesis of obesity-associated hypertension and insulin resistance",
abstract = "The intertwined epidemics of obesity and related disorders such as hypertension, insulin resistance, type 2 diabetes, and subsequent cardiovascular disease pose a major public health challenge. To meet this challenge, we must understand the interplay between adipose tissue and the vasculature. Microvascular dysfunction is important not only in the development of obesityrelated target-organ damage, but also in the development of cardiovascular risk factors such as hypertension and insulin resistance. The present chapter examines the role of microvascular dysfunction as an explanation for the associations among obesity, hypertension and impaired insulin-mediated glucose disposal. We also discuss communicative pathways from adipose tissue to the microcirculation.",
keywords = "Hypertension, Insulin resistance, Microcirculation, Obesity",
author = "Sern{\'e}, {Erik H.} and Meijer, {Rick I.} and {De Boer}, {Michiel P.} and {De Jongh}, {Renate T.} and Ijzerman, {Richard G.} and Wineke Bakker and Eringa, {Etto C.}",
year = "2009",
month = "12",
day = "1",
doi = "10.2174/978160805057410901010041",
language = "English",
isbn = "9781608056835",
pages = "41--54",
booktitle = "Microcirculation and Insulin Resistance",
publisher = "Bentham Science Publishers Ltd.",

}

Microvascular dysfunction : Potential role in the pathogenesis of obesity-associated hypertension and insulin resistance. / Serné, Erik H.; Meijer, Rick I.; De Boer, Michiel P.; De Jongh, Renate T.; Ijzerman, Richard G.; Bakker, Wineke; Eringa, Etto C.

Microcirculation and Insulin Resistance. Bentham Science Publishers Ltd., 2009. p. 41-54.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

TY - CHAP

T1 - Microvascular dysfunction

T2 - Potential role in the pathogenesis of obesity-associated hypertension and insulin resistance

AU - Serné, Erik H.

AU - Meijer, Rick I.

AU - De Boer, Michiel P.

AU - De Jongh, Renate T.

AU - Ijzerman, Richard G.

AU - Bakker, Wineke

AU - Eringa, Etto C.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - The intertwined epidemics of obesity and related disorders such as hypertension, insulin resistance, type 2 diabetes, and subsequent cardiovascular disease pose a major public health challenge. To meet this challenge, we must understand the interplay between adipose tissue and the vasculature. Microvascular dysfunction is important not only in the development of obesityrelated target-organ damage, but also in the development of cardiovascular risk factors such as hypertension and insulin resistance. The present chapter examines the role of microvascular dysfunction as an explanation for the associations among obesity, hypertension and impaired insulin-mediated glucose disposal. We also discuss communicative pathways from adipose tissue to the microcirculation.

AB - The intertwined epidemics of obesity and related disorders such as hypertension, insulin resistance, type 2 diabetes, and subsequent cardiovascular disease pose a major public health challenge. To meet this challenge, we must understand the interplay between adipose tissue and the vasculature. Microvascular dysfunction is important not only in the development of obesityrelated target-organ damage, but also in the development of cardiovascular risk factors such as hypertension and insulin resistance. The present chapter examines the role of microvascular dysfunction as an explanation for the associations among obesity, hypertension and impaired insulin-mediated glucose disposal. We also discuss communicative pathways from adipose tissue to the microcirculation.

KW - Hypertension

KW - Insulin resistance

KW - Microcirculation

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=84882637536&partnerID=8YFLogxK

U2 - 10.2174/978160805057410901010041

DO - 10.2174/978160805057410901010041

M3 - Chapter

SN - 9781608056835

SP - 41

EP - 54

BT - Microcirculation and Insulin Resistance

PB - Bentham Science Publishers Ltd.

ER -