Microvascular function has no menstrual-cycle-dependent variation in healthy ovulatory women

I.J.G. Ketel, C.D.A. Stehouwer, E.H. Serne, D.M. Poel, L. Groot, C. Kager, P.G.A. Hompes, R.R. Homburg, J.W.R. Twisk, Y.M. Smulders, C.B. Lambalk

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: Hyper-and hypoestrogenism that persist for a long time can affect vascular and metabolic function. However, it is not clear whether the same is true for subtle sex hormone changes (i.e., during the menstrual cycle). Methods: Twenty-one healthy normal-weight women with regular cycles were studied during the early-follicular (day 3 +/- 2), late-follicular (day 12 +/- 2), and midlutcal (day 20 +/- 3) phases. Microvascular function was assessed by skin iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP), by skin-capillary recruitment after arterial and venous occlusion (i.e., capillaroscopy), and by Fourier analysis of resting skin laser Doppler flow at rest (i.e., vasomotion). Insulin sensitivity (i.e., homeostasis model assessment) and blood pressure were also determined during the study days. Results: Three women were excluded from analyses because they were anovulatory. Skin microvascular responses to ACh and SNP, capillary function, vasomotion, insulin sensitivity, and blood pressure did not differ between the three phases (P >= 0.1). Further, microvascular function did not correlate with plasma-estrogen levels (r = -0.06-0.2; P >= 0.2). Conclusions: Microvascular function does not demonstrate a clear menstrual-cycle-dependent variation. Microcirculation (2009) 16, 714-724. dai:10.3109/10739680903110779
Original languageUndefined/Unknown
Pages (from-to)714-724
JournalMicrocirculation
Volume16
Issue number8
DOIs
Publication statusPublished - 2009

Cite this

Ketel, I.J.G. ; Stehouwer, C.D.A. ; Serne, E.H. ; Poel, D.M. ; Groot, L. ; Kager, C. ; Hompes, P.G.A. ; Homburg, R.R. ; Twisk, J.W.R. ; Smulders, Y.M. ; Lambalk, C.B. / Microvascular function has no menstrual-cycle-dependent variation in healthy ovulatory women. In: Microcirculation. 2009 ; Vol. 16, No. 8. pp. 714-724.
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abstract = "Objective: Hyper-and hypoestrogenism that persist for a long time can affect vascular and metabolic function. However, it is not clear whether the same is true for subtle sex hormone changes (i.e., during the menstrual cycle). Methods: Twenty-one healthy normal-weight women with regular cycles were studied during the early-follicular (day 3 +/- 2), late-follicular (day 12 +/- 2), and midlutcal (day 20 +/- 3) phases. Microvascular function was assessed by skin iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP), by skin-capillary recruitment after arterial and venous occlusion (i.e., capillaroscopy), and by Fourier analysis of resting skin laser Doppler flow at rest (i.e., vasomotion). Insulin sensitivity (i.e., homeostasis model assessment) and blood pressure were also determined during the study days. Results: Three women were excluded from analyses because they were anovulatory. Skin microvascular responses to ACh and SNP, capillary function, vasomotion, insulin sensitivity, and blood pressure did not differ between the three phases (P >= 0.1). Further, microvascular function did not correlate with plasma-estrogen levels (r = -0.06-0.2; P >= 0.2). Conclusions: Microvascular function does not demonstrate a clear menstrual-cycle-dependent variation. Microcirculation (2009) 16, 714-724. dai:10.3109/10739680903110779",
author = "I.J.G. Ketel and C.D.A. Stehouwer and E.H. Serne and D.M. Poel and L. Groot and C. Kager and P.G.A. Hompes and R.R. Homburg and J.W.R. Twisk and Y.M. Smulders and C.B. Lambalk",
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Microvascular function has no menstrual-cycle-dependent variation in healthy ovulatory women. / Ketel, I.J.G.; Stehouwer, C.D.A.; Serne, E.H.; Poel, D.M.; Groot, L.; Kager, C.; Hompes, P.G.A.; Homburg, R.R.; Twisk, J.W.R.; Smulders, Y.M.; Lambalk, C.B.

In: Microcirculation, Vol. 16, No. 8, 2009, p. 714-724.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Microvascular function has no menstrual-cycle-dependent variation in healthy ovulatory women

AU - Ketel, I.J.G.

AU - Stehouwer, C.D.A.

AU - Serne, E.H.

AU - Poel, D.M.

AU - Groot, L.

AU - Kager, C.

AU - Hompes, P.G.A.

AU - Homburg, R.R.

AU - Twisk, J.W.R.

AU - Smulders, Y.M.

AU - Lambalk, C.B.

PY - 2009

Y1 - 2009

N2 - Objective: Hyper-and hypoestrogenism that persist for a long time can affect vascular and metabolic function. However, it is not clear whether the same is true for subtle sex hormone changes (i.e., during the menstrual cycle). Methods: Twenty-one healthy normal-weight women with regular cycles were studied during the early-follicular (day 3 +/- 2), late-follicular (day 12 +/- 2), and midlutcal (day 20 +/- 3) phases. Microvascular function was assessed by skin iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP), by skin-capillary recruitment after arterial and venous occlusion (i.e., capillaroscopy), and by Fourier analysis of resting skin laser Doppler flow at rest (i.e., vasomotion). Insulin sensitivity (i.e., homeostasis model assessment) and blood pressure were also determined during the study days. Results: Three women were excluded from analyses because they were anovulatory. Skin microvascular responses to ACh and SNP, capillary function, vasomotion, insulin sensitivity, and blood pressure did not differ between the three phases (P >= 0.1). Further, microvascular function did not correlate with plasma-estrogen levels (r = -0.06-0.2; P >= 0.2). Conclusions: Microvascular function does not demonstrate a clear menstrual-cycle-dependent variation. Microcirculation (2009) 16, 714-724. dai:10.3109/10739680903110779

AB - Objective: Hyper-and hypoestrogenism that persist for a long time can affect vascular and metabolic function. However, it is not clear whether the same is true for subtle sex hormone changes (i.e., during the menstrual cycle). Methods: Twenty-one healthy normal-weight women with regular cycles were studied during the early-follicular (day 3 +/- 2), late-follicular (day 12 +/- 2), and midlutcal (day 20 +/- 3) phases. Microvascular function was assessed by skin iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP), by skin-capillary recruitment after arterial and venous occlusion (i.e., capillaroscopy), and by Fourier analysis of resting skin laser Doppler flow at rest (i.e., vasomotion). Insulin sensitivity (i.e., homeostasis model assessment) and blood pressure were also determined during the study days. Results: Three women were excluded from analyses because they were anovulatory. Skin microvascular responses to ACh and SNP, capillary function, vasomotion, insulin sensitivity, and blood pressure did not differ between the three phases (P >= 0.1). Further, microvascular function did not correlate with plasma-estrogen levels (r = -0.06-0.2; P >= 0.2). Conclusions: Microvascular function does not demonstrate a clear menstrual-cycle-dependent variation. Microcirculation (2009) 16, 714-724. dai:10.3109/10739680903110779

U2 - 10.3109/10739680903199186

DO - 10.3109/10739680903199186

M3 - Article

VL - 16

SP - 714

EP - 724

JO - Microcirculation

JF - Microcirculation

SN - 1073-9688

IS - 8

ER -