Migration of specific antibody-forming cells during the secondary immune response against horseradish peroxidase

A. A. Geldof*, M. B. v.d. Ende

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Mice were primed subcutaneously in the hind footpads with horseradish peroxidase (HRP) and boosted intravenously 10 weeks later. Removal of the popliteal lymph nodes (draining the site of primary immunization) before the booster injection markedly depressed the secondary immune response in the spleen and bone marrow. This was taken as evidence that the secondary humoral immune response against HRP in the spleen and bone marrow is largely dependent upon immigration of cells from the popliteal lymph nodes after the booster injection. In rats primed subcutaneously in the hind footpads with HRP, antibody-forming cells were demonstrated in the blood, but not in the thoracic duct lymph 3 days after an intravenous booster injection with HRP.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalVirchows Archiv B Cell Pathology Including Molecular Pathology
Volume45
Issue number1
DOIs
Publication statusPublished - 1 Jan 1984

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