Minor histocompatibility antigens in GVL

Tuna Mutis, Els Goulmy

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

In syngeneic bone marrow transplantation (BMT) and in recipients of autologous BMT, relapse rates are high. No MHC or minor histocompatibility antigen (mHag) disparities exist and thus no alloreactivities can be induced. This is clearly different in allogeneic BMT, where the relapse rates are significantly lower and a relationship is seen between the graft-versus leukemia (GVL) effect and acute and chronic graft-versus-host disease (GVHD). Likewise, donor lymphocyte infusion (DLI) therapy, inducing remission in relapsed chronic myeloid leukemia (CML) after allogeneic BMT, is frequently accompanied by GVHD. Thus, one may conclude that alloreactive donor T cells are involved in antileukemia reactivities. Human mHag are polymorphic antigens that are independent from HLA, expressed on leukemic cells, and recognized by alloreactive immune bone marrow donor T cells. It is therefore likely that in the HLA-identical situation, mHag participate in GVL reactivities. This review does not cover the information regarding the GVL effect of murine mHag. These and other experimental animal studies are described in Chapter 3. Here we summarize current knowledge of the putative impact of human mHag on the GVL effect in BMT and discusses the possible clinical application of mHag for immunotherapy of leukemia.

Original languageEnglish
Title of host publicationAllogeneic Immunotherapy for Malignant Diseases
PublisherCRC Press
Pages119-133
Number of pages15
ISBN (Electronic)9780203909508
ISBN (Print)9780824767815
Publication statusPublished - 1 Jan 2000

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