MiRNA profiling for diagnosis, prognosis and stratification of cancer treatment in cholangiocarcinoma

Jisce R. Puik, Laura L. Meijer, Tessa Y.S. Le Large, Mireia Mato Prado, Adam E. Frampton, Geert Kazemier, Elisa Giovannetti

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Cholangiocarcinoma (CCA) is a lethal malignancy originating from the biliary tract epithelium. Most patients are diagnosed at an advanced stage. Even after resection with curative intent, prognosis remains poor. Previous studies have reported the evolving role of miRNAs as novel biomarkers in cancer diagnosis, prognostication and chemotherapy response. Various miRNAs, such as miR-21, miR-26, miR-122 and miR-150, have been identified as possible blood-based biomarkers for noninvasive diagnosis of CCA. Moreover, epithelial-mesenchymal transition (EMT)- and angiogenesis-associated miRNAs have been implicated in tumor cell dissemination and are able to determine clinical outcome. In fact, miRNAs involved in cell survival might even determine chemotherapy response. This review provides an overview of known miRNAs as CCA-specific biomarkers.

Original languageEnglish
Pages (from-to)1343-1358
Number of pages16
JournalPharmacogenomics
Volume18
Issue number14
DOIs
Publication statusPublished - 1 Sep 2017

Cite this

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title = "MiRNA profiling for diagnosis, prognosis and stratification of cancer treatment in cholangiocarcinoma",
abstract = "Cholangiocarcinoma (CCA) is a lethal malignancy originating from the biliary tract epithelium. Most patients are diagnosed at an advanced stage. Even after resection with curative intent, prognosis remains poor. Previous studies have reported the evolving role of miRNAs as novel biomarkers in cancer diagnosis, prognostication and chemotherapy response. Various miRNAs, such as miR-21, miR-26, miR-122 and miR-150, have been identified as possible blood-based biomarkers for noninvasive diagnosis of CCA. Moreover, epithelial-mesenchymal transition (EMT)- and angiogenesis-associated miRNAs have been implicated in tumor cell dissemination and are able to determine clinical outcome. In fact, miRNAs involved in cell survival might even determine chemotherapy response. This review provides an overview of known miRNAs as CCA-specific biomarkers.",
keywords = "bile duct cancer, cholangiocarcinoma, diagnosis, liquid biopsy, miRNA, prediction, prognosis",
author = "Puik, {Jisce R.} and Meijer, {Laura L.} and {Le Large}, {Tessa Y.S.} and Prado, {Mireia Mato} and Frampton, {Adam E.} and Geert Kazemier and Elisa Giovannetti",
year = "2017",
month = "9",
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language = "English",
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MiRNA profiling for diagnosis, prognosis and stratification of cancer treatment in cholangiocarcinoma. / Puik, Jisce R.; Meijer, Laura L.; Le Large, Tessa Y.S.; Prado, Mireia Mato; Frampton, Adam E.; Kazemier, Geert; Giovannetti, Elisa.

In: Pharmacogenomics, Vol. 18, No. 14, 01.09.2017, p. 1343-1358.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - MiRNA profiling for diagnosis, prognosis and stratification of cancer treatment in cholangiocarcinoma

AU - Puik, Jisce R.

AU - Meijer, Laura L.

AU - Le Large, Tessa Y.S.

AU - Prado, Mireia Mato

AU - Frampton, Adam E.

AU - Kazemier, Geert

AU - Giovannetti, Elisa

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Cholangiocarcinoma (CCA) is a lethal malignancy originating from the biliary tract epithelium. Most patients are diagnosed at an advanced stage. Even after resection with curative intent, prognosis remains poor. Previous studies have reported the evolving role of miRNAs as novel biomarkers in cancer diagnosis, prognostication and chemotherapy response. Various miRNAs, such as miR-21, miR-26, miR-122 and miR-150, have been identified as possible blood-based biomarkers for noninvasive diagnosis of CCA. Moreover, epithelial-mesenchymal transition (EMT)- and angiogenesis-associated miRNAs have been implicated in tumor cell dissemination and are able to determine clinical outcome. In fact, miRNAs involved in cell survival might even determine chemotherapy response. This review provides an overview of known miRNAs as CCA-specific biomarkers.

AB - Cholangiocarcinoma (CCA) is a lethal malignancy originating from the biliary tract epithelium. Most patients are diagnosed at an advanced stage. Even after resection with curative intent, prognosis remains poor. Previous studies have reported the evolving role of miRNAs as novel biomarkers in cancer diagnosis, prognostication and chemotherapy response. Various miRNAs, such as miR-21, miR-26, miR-122 and miR-150, have been identified as possible blood-based biomarkers for noninvasive diagnosis of CCA. Moreover, epithelial-mesenchymal transition (EMT)- and angiogenesis-associated miRNAs have been implicated in tumor cell dissemination and are able to determine clinical outcome. In fact, miRNAs involved in cell survival might even determine chemotherapy response. This review provides an overview of known miRNAs as CCA-specific biomarkers.

KW - bile duct cancer

KW - cholangiocarcinoma

KW - diagnosis

KW - liquid biopsy

KW - miRNA

KW - prediction

KW - prognosis

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U2 - 10.2217/pgs-2017-0010

DO - 10.2217/pgs-2017-0010

M3 - Review article

VL - 18

SP - 1343

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JO - Pharmacogenomics

JF - Pharmacogenomics

SN - 1462-2416

IS - 14

ER -