Models for cancer skeletal metastasis: A reappraisal of Batson's plexus

Albert A. Geldof*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

While skeletal metastasis in prostate cancer is a major and frequent complication, literature data on the mechanisms involved are quite confusing. Recent efforts, however, to establish appropriate animal models for skeletal metastasis have finally yielded positive results which may provide clarity in this discussion. Models involving both human prostate cancer cell transplantation in nude mice as well as syngeneic rat models have contributed to the accumulated evidence in favor of the hypothesis of Batson. According to this hypothesis, prostate tumor cells reach the vertebral venous plexus of the spine especially under transient conditions of increased intra-abdominal pressure and lead to metastatic tumor deposits in the vertebrae. Animal models displaying skeletal metastasis in conjunction with analysis of pathological findings have been instrumental in validating this concept. It is to be expected that such animal models will contribute to the development and optimization of new treatment approaches for prostate cancer bone metastasis.

Original languageEnglish
Pages (from-to)1535-1539
Number of pages5
JournalAnticancer Research
Volume17
Issue number3 A
Publication statusPublished - 1 Jul 1997

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