TY - JOUR
T1 - Modifiable Risk Factors for Prevention of Dementia in Midlife, Late Life and the Oldest-Old
T2 - Validation of the LIBRA Index
AU - Vos, Stephanie J.B.
AU - Van Boxtel, Martin P.J.
AU - Schiepers, Olga J.G.
AU - Deckers, Kay
AU - De Vugt, Marjolein
AU - Carrière, Isabelle
AU - Dartigues, Jean François
AU - Peres, Karine
AU - Artero, Sylvaine
AU - Ritchie, Karen
AU - Galluzzo, Lucia
AU - Scafato, Emanuele
AU - Frisoni, Giovanni B.
AU - Huisman, Martijn
AU - Comijs, Hannie C.
AU - Sacuiu, Simona F.
AU - Skoog, Ingmar
AU - Irving, Kate
AU - O'Donnell, Catherine A.
AU - Verhey, Frans R.J.
AU - Visser, Pieter Jelle
AU - Köhler, Sebastian
PY - 2017
Y1 - 2017
N2 - Background: Recently, the LIfestyle for BRAin health (LIBRA) index was developed to assess an individual's prevention potential for dementia. Objective: We investigated the predictive validity of the LIBRA index for incident dementia in midlife, late life, and the oldest-old. Methods: 9,387 non-demented individuals were recruited from the European population-based DESCRIPAstudy.An individual'sLIBRAindexwas calculated solely based on modifiable risk factors: depression, diabetes, physical activity, hypertension, obesity, smoking, hypercholesterolemia, coronary heart disease, and mild/moderate alcohol use. Cox regression was used to test the predictive validity of LIBRA for dementia at follow-up (mean 7.2 y, range 1 16). Results: In midlife (55 69 y, n = 3,256) and late life (70 79 y, n = 4,320), the risk for dementia increased with higher LIBRA scores. Individuals in the intermediate- and high-risk groups had a higher risk of dementia than those in the low-risk group. In the oldest-old (80 97 y, n = 1,811), higher LIBRA scores did not increase the risk for dementia. Conclusion: LIBRA might be a useful tool to identify individuals for primary prevention interventions of dementia in midlife, and maybe in late life, but not in the oldest-old.
AB - Background: Recently, the LIfestyle for BRAin health (LIBRA) index was developed to assess an individual's prevention potential for dementia. Objective: We investigated the predictive validity of the LIBRA index for incident dementia in midlife, late life, and the oldest-old. Methods: 9,387 non-demented individuals were recruited from the European population-based DESCRIPAstudy.An individual'sLIBRAindexwas calculated solely based on modifiable risk factors: depression, diabetes, physical activity, hypertension, obesity, smoking, hypercholesterolemia, coronary heart disease, and mild/moderate alcohol use. Cox regression was used to test the predictive validity of LIBRA for dementia at follow-up (mean 7.2 y, range 1 16). Results: In midlife (55 69 y, n = 3,256) and late life (70 79 y, n = 4,320), the risk for dementia increased with higher LIBRA scores. Individuals in the intermediate- and high-risk groups had a higher risk of dementia than those in the low-risk group. In the oldest-old (80 97 y, n = 1,811), higher LIBRA scores did not increase the risk for dementia. Conclusion: LIBRA might be a useful tool to identify individuals for primary prevention interventions of dementia in midlife, and maybe in late life, but not in the oldest-old.
KW - Aging
KW - dementia
KW - modifiable risk factors
KW - prevention
UR - http://www.scopus.com/inward/record.url?scp=85019263466&partnerID=8YFLogxK
U2 - 10.3233/JAD-161208
DO - 10.3233/JAD-161208
M3 - Article
C2 - 28453475
AN - SCOPUS:85019263466
VL - 58
SP - 537
EP - 547
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 2
ER -