Molecular imaging in dementia: Past, present, and future

Robert Laforce, Jean-Paul Soucy, Leila Sellami, Caroline Dallaire-Théroux, Francis Brunet, David Bergeron, Bruce L. Miller, Rik Ossenkoppele

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Molecular imaging techniques using 18F-fluorodeoxyglucose, amyloid tracers, and, more recently, tau ligands have taken dementia research by storm and undoubtedly improved our understanding of neurodegenerative diseases. The ability to image in vivo the pathological substrates of degenerative diseases and visualize their downstream impact has led to improved models of pathogenesis, better differential diagnosis of atypical conditions, as well as focused subject selection and monitoring of treatment in clinical trials aimed at delaying or preventing the symptomatic phase of Alzheimer's disease. In this article, we present the main molecular imaging techniques used in research and practice. We further summarize the key findings brought about by each technique individually and more recently, as adjuncts to each other. Specific limitations of each imaging modality are discussed, as well as recommendations to overcome them. A nonvalidated clinical algorithm is proposed for earlier and more accurate identification of complex/atypical neurodegenerative diseases.
Original languageEnglish
Pages (from-to)1522-1552
JournalAlzheimer's and Dementia
Volume14
Issue number11
DOIs
Publication statusPublished - 2018

Cite this

Laforce, R., Soucy, J-P., Sellami, L., Dallaire-Théroux, C., Brunet, F., Bergeron, D., ... Ossenkoppele, R. (2018). Molecular imaging in dementia: Past, present, and future. Alzheimer's and Dementia, 14(11), 1522-1552. https://doi.org/10.1016/j.jalz.2018.06.2855