Monocyte activation and disease activity in multiple sclerosis. A longitudinal analysis of serum MRP8/14 levels

Sarah Floris, Annette van der Goes, Joep Killestein, Dirk L Knol, Frederik Barkhof, Chris H Polman, Christine D Dijkstra, Helga E de Vries, Jan F Meilof

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In active multiple sclerosis (MS) lesions macrophages expressing myeloid related protein (MRP) 8/14 are present. The aim of this study was to determine whether serum levels of MRP8/14 complexes are related to disease activity in MS. In a longitudinal study of 16 relapsing remitting (RR) MS patients that underwent monthly gadolinium diethylentriaminepenta acid (Gd-DTPA) magnetic resonance imaging (MRI), the relation between serum MRP8/14 levels and disease activity was investigated. Patients were participating in a monoclonal antibody study targeting a specific T cell population (Vbeta5.2/5.3+ T-cells). In time, within patients large variations in serum MRP8/14 levels were observed. Serum MRP8/14 levels were not related to changes in clinical disease activity or increase in Gd-DTPA lesion enhancement. Neither did comparison of active (>1 relapse in follow-up period) with inactive (0-1 relapse) MS patients reveal any differences in MRP8/14 levels. Therefore, we conclude that although MRP8/14 expression is a good histopathological marker for monocyte activation, serum levels of these proteins do not correlate with disease activity in RR MS.

Original languageEnglish
Pages (from-to)172-7
Number of pages6
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - Mar 2004

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