Morphology and flow cytometry

Katja Sockel, Frank Kroschinsky, Uta Oelschlaegel, Arjan A. van de Loosdrecht

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

Despite the rapid development of molecular markers during the last years, the morphology of blood and bone marrow cells still keeps the crucial role for diagnosis and subclassification of the different subtypes of myelodysplastic syndromes (MDS), as recently confirmed by the new 2016 WHO classification [1]. Nevertheless, morphologic diagnosis is not always self-evident. While increased blast cells are often in-line with advanced MDS subtypes, early forms with mild morphological changes can represent a diagnostic challenge. Especially in these cases, morphologic experience is crucial but should be embedded into further information on disease history, exclusion of other underlying diseases, as well as additional cytogenetic, molecular, and immunophenotypic data to confirm diagnosis of MDS.
Original languageEnglish
Title of host publicationHematologic Malignancies
PublisherSpringer Verlag
Pages3-13
DOIs
Publication statusPublished - 2018

Publication series

NameHematologic Malignancies
ISSN (Print)2197-9766
ISSN (Electronic)2197-9774

Cite this

Sockel, K., Kroschinsky, F., Oelschlaegel, U., & van de Loosdrecht, A. A. (2018). Morphology and flow cytometry. In Hematologic Malignancies (pp. 3-13). (Hematologic Malignancies). Springer Verlag. https://doi.org/10.1007/978-3-319-76879-3_1
Sockel, Katja ; Kroschinsky, Frank ; Oelschlaegel, Uta ; van de Loosdrecht, Arjan A. / Morphology and flow cytometry. Hematologic Malignancies. Springer Verlag, 2018. pp. 3-13 (Hematologic Malignancies).
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Sockel, K, Kroschinsky, F, Oelschlaegel, U & van de Loosdrecht, AA 2018, Morphology and flow cytometry. in Hematologic Malignancies. Hematologic Malignancies, Springer Verlag, pp. 3-13. https://doi.org/10.1007/978-3-319-76879-3_1

Morphology and flow cytometry. / Sockel, Katja; Kroschinsky, Frank; Oelschlaegel, Uta; van de Loosdrecht, Arjan A.

Hematologic Malignancies. Springer Verlag, 2018. p. 3-13 (Hematologic Malignancies).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

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AB - Despite the rapid development of molecular markers during the last years, the morphology of blood and bone marrow cells still keeps the crucial role for diagnosis and subclassification of the different subtypes of myelodysplastic syndromes (MDS), as recently confirmed by the new 2016 WHO classification [1]. Nevertheless, morphologic diagnosis is not always self-evident. While increased blast cells are often in-line with advanced MDS subtypes, early forms with mild morphological changes can represent a diagnostic challenge. Especially in these cases, morphologic experience is crucial but should be embedded into further information on disease history, exclusion of other underlying diseases, as well as additional cytogenetic, molecular, and immunophenotypic data to confirm diagnosis of MDS.

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Sockel K, Kroschinsky F, Oelschlaegel U, van de Loosdrecht AA. Morphology and flow cytometry. In Hematologic Malignancies. Springer Verlag. 2018. p. 3-13. (Hematologic Malignancies). https://doi.org/10.1007/978-3-319-76879-3_1