Moving towards a cure in genetics: what is needed to bring somatic gene therapy to the clinic?

Martina C. Cornel, Heidi C. Howard, Daniel Lim, Vence L. Bonham, Kirmo Wartiovaara

Research output: Contribution to journalArticleAcademicpeer-review


Clinical trials using somatic gene editing (e.g., CRISPR–Cas9) have started in Europe and the United States and may provide safe and effective treatment and cure, not only for cancers but also for some monogenic conditions. In a workshop at the 2018 European Human Genetics Conference, the challenges of bringing somatic gene editing therapies to the clinic were discussed. The regulatory process needs to be considered early in the clinical development pathway to produce the data necessary to support the approval by the European Medicines Agency. The roles and responsibilities for geneticists may include counselling to explain the treatment possibilities and safety interpretation.

Original languageEnglish
Pages (from-to)484-487
Number of pages4
JournalEuropean Journal of Human Genetics
Issue number3
Publication statusPublished - 1 Mar 2019

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