MR venography of multiple sclerosis

I. Leng Tan, Ronald A. Van Schijndel, Petra J W Pouwels, Marianne A A Van Walderveen, Juergen R. Reichenbach, Radu A. Manoliu, Frederik Barkhof

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND AND PURPOSE: The distribution of multiple sclerosis (MS) lesions in the brain follows a specific pattern, with most lesions in the periventricular regions and in the deep white matter; histopathologic studies have shown a perivenous distribution. The aim of this study was to illustrate these distribution patterns in vivo using high-resolution MR venography. METHODS: Seventeen MS patients underwent MR imaging at 1.5 T. Venographic studies were obtained with a 3D gradient-echo technique. MS lesions were identified on T2-weighted images, and their shape, orientation, and location were compared with the venous anatomy on the venograms. RESULTS: The use of contrast material facilitated the visualization of small veins and increased the number of veins seen. A total of 95 MS lesions could be identified on both the T2-weighted series and the venograms; a central vein was visible in all 43 periventricular lesions and in all but one of the 52 focal deep white matter lesions. The typical ovoid shape and orientation of the long axis of the MS lesions correlated well with the course of these veins. CONCLUSION: With MR venography, the perivenous distribution of MS lesions in the brain can be visualized in vivo. The venous anatomy defines the typical form and orientation of these lesions.

Original languageEnglish
Pages (from-to)1039-1042
Number of pages4
JournalAmerican Journal of Neuroradiology
Volume21
Issue number6
Publication statusPublished - 30 Jun 2000

Cite this

Tan, I. L., Van Schijndel, R. A., Pouwels, P. J. W., Van Walderveen, M. A. A., Reichenbach, J. R., Manoliu, R. A., & Barkhof, F. (2000). MR venography of multiple sclerosis. American Journal of Neuroradiology, 21(6), 1039-1042.
Tan, I. Leng ; Van Schijndel, Ronald A. ; Pouwels, Petra J W ; Van Walderveen, Marianne A A ; Reichenbach, Juergen R. ; Manoliu, Radu A. ; Barkhof, Frederik. / MR venography of multiple sclerosis. In: American Journal of Neuroradiology. 2000 ; Vol. 21, No. 6. pp. 1039-1042.
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abstract = "BACKGROUND AND PURPOSE: The distribution of multiple sclerosis (MS) lesions in the brain follows a specific pattern, with most lesions in the periventricular regions and in the deep white matter; histopathologic studies have shown a perivenous distribution. The aim of this study was to illustrate these distribution patterns in vivo using high-resolution MR venography. METHODS: Seventeen MS patients underwent MR imaging at 1.5 T. Venographic studies were obtained with a 3D gradient-echo technique. MS lesions were identified on T2-weighted images, and their shape, orientation, and location were compared with the venous anatomy on the venograms. RESULTS: The use of contrast material facilitated the visualization of small veins and increased the number of veins seen. A total of 95 MS lesions could be identified on both the T2-weighted series and the venograms; a central vein was visible in all 43 periventricular lesions and in all but one of the 52 focal deep white matter lesions. The typical ovoid shape and orientation of the long axis of the MS lesions correlated well with the course of these veins. CONCLUSION: With MR venography, the perivenous distribution of MS lesions in the brain can be visualized in vivo. The venous anatomy defines the typical form and orientation of these lesions.",
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Tan, IL, Van Schijndel, RA, Pouwels, PJW, Van Walderveen, MAA, Reichenbach, JR, Manoliu, RA & Barkhof, F 2000, 'MR venography of multiple sclerosis' American Journal of Neuroradiology, vol. 21, no. 6, pp. 1039-1042.

MR venography of multiple sclerosis. / Tan, I. Leng; Van Schijndel, Ronald A.; Pouwels, Petra J W; Van Walderveen, Marianne A A; Reichenbach, Juergen R.; Manoliu, Radu A.; Barkhof, Frederik.

In: American Journal of Neuroradiology, Vol. 21, No. 6, 30.06.2000, p. 1039-1042.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - MR venography of multiple sclerosis

AU - Tan, I. Leng

AU - Van Schijndel, Ronald A.

AU - Pouwels, Petra J W

AU - Van Walderveen, Marianne A A

AU - Reichenbach, Juergen R.

AU - Manoliu, Radu A.

AU - Barkhof, Frederik

PY - 2000/6/30

Y1 - 2000/6/30

N2 - BACKGROUND AND PURPOSE: The distribution of multiple sclerosis (MS) lesions in the brain follows a specific pattern, with most lesions in the periventricular regions and in the deep white matter; histopathologic studies have shown a perivenous distribution. The aim of this study was to illustrate these distribution patterns in vivo using high-resolution MR venography. METHODS: Seventeen MS patients underwent MR imaging at 1.5 T. Venographic studies were obtained with a 3D gradient-echo technique. MS lesions were identified on T2-weighted images, and their shape, orientation, and location were compared with the venous anatomy on the venograms. RESULTS: The use of contrast material facilitated the visualization of small veins and increased the number of veins seen. A total of 95 MS lesions could be identified on both the T2-weighted series and the venograms; a central vein was visible in all 43 periventricular lesions and in all but one of the 52 focal deep white matter lesions. The typical ovoid shape and orientation of the long axis of the MS lesions correlated well with the course of these veins. CONCLUSION: With MR venography, the perivenous distribution of MS lesions in the brain can be visualized in vivo. The venous anatomy defines the typical form and orientation of these lesions.

AB - BACKGROUND AND PURPOSE: The distribution of multiple sclerosis (MS) lesions in the brain follows a specific pattern, with most lesions in the periventricular regions and in the deep white matter; histopathologic studies have shown a perivenous distribution. The aim of this study was to illustrate these distribution patterns in vivo using high-resolution MR venography. METHODS: Seventeen MS patients underwent MR imaging at 1.5 T. Venographic studies were obtained with a 3D gradient-echo technique. MS lesions were identified on T2-weighted images, and their shape, orientation, and location were compared with the venous anatomy on the venograms. RESULTS: The use of contrast material facilitated the visualization of small veins and increased the number of veins seen. A total of 95 MS lesions could be identified on both the T2-weighted series and the venograms; a central vein was visible in all 43 periventricular lesions and in all but one of the 52 focal deep white matter lesions. The typical ovoid shape and orientation of the long axis of the MS lesions correlated well with the course of these veins. CONCLUSION: With MR venography, the perivenous distribution of MS lesions in the brain can be visualized in vivo. The venous anatomy defines the typical form and orientation of these lesions.

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Tan IL, Van Schijndel RA, Pouwels PJW, Van Walderveen MAA, Reichenbach JR, Manoliu RA et al. MR venography of multiple sclerosis. American Journal of Neuroradiology. 2000 Jun 30;21(6):1039-1042.