MRI-guided immunotherapy development for multiple sclerosis in a primate

Bert A 't Hart; Paul Smith; Sandra Amor; Gustav J Strijkers; Erwin L A Blezer

doi:10.1016/S1359-6446(05)03673-1

MRI-guided immunotherapy development for multiple sclerosis in a primate

Bert A 't Hart, Paul Smith, Sandra Amor, Gustav J Strijkers, Erwin L A Blezer

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Multiple sclerosis is a serious neurological disease that affects 1 in 1000 young adults in Europe and the USA. The development of an effective therapy for this enigmatic disease is plagued by the failure of many treatments to reproduce in patients the promising effects observed in animal models. This review describes a new preclinical model in a non-human primate that might help to bridge the gap between currently used animal models and the patients.

Original language	English
Pages (from-to)	58-66
Number of pages	9
Journal	Drug Discovery Today
Volume	11
Issue number	1-2
DOIs	https://doi.org/10.1016/S1359-6446(05)03673-1
Publication status	Published - Jan 2006

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10.1016/S1359-6446(05)03673-1

Cite this

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title = "MRI-guided immunotherapy development for multiple sclerosis in a primate",

abstract = "Multiple sclerosis is a serious neurological disease that affects 1 in 1000 young adults in Europe and the USA. The development of an effective therapy for this enigmatic disease is plagued by the failure of many treatments to reproduce in patients the promising effects observed in animal models. This review describes a new preclinical model in a non-human primate that might help to bridge the gap between currently used animal models and the patients.",

keywords = "Animals, Brain, Callithrix, Disease Models, Animal, Immunotherapy, Magnetic Resonance Imaging, Multiple Sclerosis, Journal Article, Research Support, Non-U.S. Gov't, Review",

author = "{'t Hart}, {Bert A} and Paul Smith and Sandra Amor and Strijkers, {Gustav J} and Blezer, {Erwin L A}",

year = "2006",

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language = "English",

volume = "11",

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journal = "Drug Discovery Today",

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AU - 't Hart, Bert A

AU - Smith, Paul

AU - Amor, Sandra

AU - Strijkers, Gustav J

AU - Blezer, Erwin L A

PY - 2006/1

Y1 - 2006/1

N2 - Multiple sclerosis is a serious neurological disease that affects 1 in 1000 young adults in Europe and the USA. The development of an effective therapy for this enigmatic disease is plagued by the failure of many treatments to reproduce in patients the promising effects observed in animal models. This review describes a new preclinical model in a non-human primate that might help to bridge the gap between currently used animal models and the patients.

AB - Multiple sclerosis is a serious neurological disease that affects 1 in 1000 young adults in Europe and the USA. The development of an effective therapy for this enigmatic disease is plagued by the failure of many treatments to reproduce in patients the promising effects observed in animal models. This review describes a new preclinical model in a non-human primate that might help to bridge the gap between currently used animal models and the patients.

KW - Animals

KW - Brain

KW - Callithrix

KW - Disease Models, Animal

KW - Immunotherapy

KW - Magnetic Resonance Imaging

KW - Multiple Sclerosis

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1016/S1359-6446(05)03673-1

DO - 10.1016/S1359-6446(05)03673-1

M3 - Review article

C2 - 16478692

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VL - 11

SP - 58

EP - 66

JO - Drug Discovery Today

JF - Drug Discovery Today

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ER -