MRP8/14 and neutrophil elastase for predicting treatment response and occurrence of flare in patients with juvenile idiopathic arthritis

Anouk M Barendregt, Saskia R Veldkamp, Petra C E Hissink Muller, Annemarie van de Geer, Cathelijn Aarts, E Charlotte van Gulik, Marco W Schilham, Christoph Kessel, Mischa P Keizer, Robert Hemke, Amara Nassar-Sheikh Rashid, Koert M Dolman, Dieneke Schonenberg-Meinema, Rebecca Ten Cate, J Merlijn van den Berg, Mario Maas, Taco W Kuijpers

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Objective: To study two neutrophil activation markers, myeloid-related protein (MRP) 8/14 and neutrophil elastase (NE), for their ability to predict treatment response and flare in patients with JIA. Methods: Using samples from two cohorts (I and II), we determined MRP8/14 and NE levels of 32 (I) and 81 (II) patients with new-onset, DMARD-naïve arthritis and compared patients who responded to treatment (defined as fulfilling ≥ adjusted ACRpedi50 response and/or inactive disease) with non-responders (defined as fulfilling < adjusted ACRpedi50 response and/or active disease) at 6 and 12 months. Secondly, we compared biomarker levels of 54 (I) and 34 (II) patients with clinically inactive disease who did or did not suffer from a flare of arthritis after 6 or 12 months. Receiver operating characteristic analyses were carried out to study the predictive value of MRP8/14 and NE for treatment response and flare. Results: For both cohorts, baseline MRP8/14 and NE levels for patients who did or did not respond to treatment were not different. Also, MRP8/14 and NE levels were not different in patients who did or did not flare. Receiver operating characteristic analysis of MRP8/14 and NE demonstrated areas under the curve <0.7 in both cohorts. Conclusion: In our cohorts, MRP8/14 and NE could not predict treatment response. Also, when patients had inactive disease, neither marker could predict flares.

Original languageEnglish
Pages (from-to)2392-2401
Number of pages10
JournalRheumatology (Oxford, England)
Issue number9
Publication statusPublished - 1 Sep 2020

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