MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells

E. Saeland, M.A.W.P. de Jong, A. Nabatov, H. Kalay, Y. van Kooyk, T.B.H. Geijtenbeek

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Mother-to-child transmission of human immunodeficiency virus-1 (HIV-1) occurs frequently via breast-feeding. HIV-1 targets DC-SIGN+ dendritic cells (DCs) in mucosal areas that allow efficient transmission of the virus to T cells. Here, we demonstrate that the epithelial mucin MUC1, abundant in milk, efficiently bound to DC-SIGN on DC. The O-linked glycans within the mucin domain contained Lewis X structures, that were specifically recognized by the receptor. Interestingly, MUC1 prevented DC-SIGN-mediated transmission of HIV-1 from DCs to CD4+ T cells. We hypothesize that repetitive units of Lewis X, within the mucin domain, play an important role in inhibiting transmission of HIV-1 from mother to child. (C) 2009 Elsevier Ltd. All rights reserved
Original languageUndefined/Unknown
Pages (from-to)2309-2316
JournalMolecular Immunology
Volume46
Issue number11-12
DOIs
Publication statusPublished - 2009

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