Multi-contrast, isotropic, single-slab 3D MR imaging in multiple sclerosis

Bastiaan Moraal, Stefan D. Roosendaal, Petra J W Pouwels, Hugo Vrenken, Ronald A. Van Schijndel, Dominik S. Meier, Charles R G Guttmann, Jeroen J G Geurts, Frederik Barkhof

Research output: Contribution to journalErratumAcademicpeer-review

Abstract

To describe signal and contrast properties of an isotropic, single-slab 3D dataset [double inversion-recovery (DIR), fluid-attenuated inversion recovery (FLAIR), T2, and T1-weighted magnetization prepared rapid acquisition gradient-echo (MPRAGE)] and to evaluate its performance in detecting multiple sclerosis (MS) brain lesions compared to 2D T2-weighted spin-echo (T2SE). All single-slab 3D sequences and 2D-T2SE were acquired in 16 MS patients and 9 age-matched healthy controls. Lesions were scored independently by two raters and characterized anatomically. Two-tailed Bonferroni-corrected Student's t-tests were used to detect differences in lesion detection between the various sequences per anatomical area after log-transformation. In general, signal and contrast properties of the 3D sequences enabled improved detection of MS brain lesions compared to 2D-T2SE. Specifically, 3D-DIR showed the highest detection of intracortical and mixed WM-GM lesions, whereas 3D-FLAIR showed the highest total number of WM lesions. Both 3D-DIR and 3D-FLAIR showed the highest number of infratentorial lesions. 3D-T2 and 3D-MPRAGE did not improve lesion detection compared to 2D-T2SE. Multi-contrast, isotropic, single-slab 3D MRI allowed an improved detection of both GM and WM lesions compared to 2D-T2SE. A selection of single-slab 3D contrasts, for example, 3D-FLAIR and 3D-DIR, could replace 2D sequences in the radiological practice.

Original languageEnglish
Pages (from-to)33-42
Number of pages10
JournalNeuroradiology Journal
Volume22
Issue numberSUPPL. 1
Publication statusPublished - 27 Nov 2009

Cite this

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title = "Multi-contrast, isotropic, single-slab 3D MR imaging in multiple sclerosis",
abstract = "To describe signal and contrast properties of an isotropic, single-slab 3D dataset [double inversion-recovery (DIR), fluid-attenuated inversion recovery (FLAIR), T2, and T1-weighted magnetization prepared rapid acquisition gradient-echo (MPRAGE)] and to evaluate its performance in detecting multiple sclerosis (MS) brain lesions compared to 2D T2-weighted spin-echo (T2SE). All single-slab 3D sequences and 2D-T2SE were acquired in 16 MS patients and 9 age-matched healthy controls. Lesions were scored independently by two raters and characterized anatomically. Two-tailed Bonferroni-corrected Student's t-tests were used to detect differences in lesion detection between the various sequences per anatomical area after log-transformation. In general, signal and contrast properties of the 3D sequences enabled improved detection of MS brain lesions compared to 2D-T2SE. Specifically, 3D-DIR showed the highest detection of intracortical and mixed WM-GM lesions, whereas 3D-FLAIR showed the highest total number of WM lesions. Both 3D-DIR and 3D-FLAIR showed the highest number of infratentorial lesions. 3D-T2 and 3D-MPRAGE did not improve lesion detection compared to 2D-T2SE. Multi-contrast, isotropic, single-slab 3D MRI allowed an improved detection of both GM and WM lesions compared to 2D-T2SE. A selection of single-slab 3D contrasts, for example, 3D-FLAIR and 3D-DIR, could replace 2D sequences in the radiological practice.",
keywords = "Cortical, DIR, FLAIR, Flow artifacts, Infratentorial",
author = "Bastiaan Moraal and Roosendaal, {Stefan D.} and Pouwels, {Petra J W} and Hugo Vrenken and {Van Schijndel}, {Ronald A.} and Meier, {Dominik S.} and Guttmann, {Charles R G} and Geurts, {Jeroen J G} and Frederik Barkhof",
year = "2009",
month = "11",
day = "27",
language = "English",
volume = "22",
pages = "33--42",
journal = "The Neuroradiology Journal",
issn = "1971-4009",
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}

Multi-contrast, isotropic, single-slab 3D MR imaging in multiple sclerosis. / Moraal, Bastiaan; Roosendaal, Stefan D.; Pouwels, Petra J W; Vrenken, Hugo; Van Schijndel, Ronald A.; Meier, Dominik S.; Guttmann, Charles R G; Geurts, Jeroen J G; Barkhof, Frederik.

In: Neuroradiology Journal, Vol. 22, No. SUPPL. 1, 27.11.2009, p. 33-42.

Research output: Contribution to journalErratumAcademicpeer-review

TY - JOUR

T1 - Multi-contrast, isotropic, single-slab 3D MR imaging in multiple sclerosis

AU - Moraal, Bastiaan

AU - Roosendaal, Stefan D.

AU - Pouwels, Petra J W

AU - Vrenken, Hugo

AU - Van Schijndel, Ronald A.

AU - Meier, Dominik S.

AU - Guttmann, Charles R G

AU - Geurts, Jeroen J G

AU - Barkhof, Frederik

PY - 2009/11/27

Y1 - 2009/11/27

N2 - To describe signal and contrast properties of an isotropic, single-slab 3D dataset [double inversion-recovery (DIR), fluid-attenuated inversion recovery (FLAIR), T2, and T1-weighted magnetization prepared rapid acquisition gradient-echo (MPRAGE)] and to evaluate its performance in detecting multiple sclerosis (MS) brain lesions compared to 2D T2-weighted spin-echo (T2SE). All single-slab 3D sequences and 2D-T2SE were acquired in 16 MS patients and 9 age-matched healthy controls. Lesions were scored independently by two raters and characterized anatomically. Two-tailed Bonferroni-corrected Student's t-tests were used to detect differences in lesion detection between the various sequences per anatomical area after log-transformation. In general, signal and contrast properties of the 3D sequences enabled improved detection of MS brain lesions compared to 2D-T2SE. Specifically, 3D-DIR showed the highest detection of intracortical and mixed WM-GM lesions, whereas 3D-FLAIR showed the highest total number of WM lesions. Both 3D-DIR and 3D-FLAIR showed the highest number of infratentorial lesions. 3D-T2 and 3D-MPRAGE did not improve lesion detection compared to 2D-T2SE. Multi-contrast, isotropic, single-slab 3D MRI allowed an improved detection of both GM and WM lesions compared to 2D-T2SE. A selection of single-slab 3D contrasts, for example, 3D-FLAIR and 3D-DIR, could replace 2D sequences in the radiological practice.

AB - To describe signal and contrast properties of an isotropic, single-slab 3D dataset [double inversion-recovery (DIR), fluid-attenuated inversion recovery (FLAIR), T2, and T1-weighted magnetization prepared rapid acquisition gradient-echo (MPRAGE)] and to evaluate its performance in detecting multiple sclerosis (MS) brain lesions compared to 2D T2-weighted spin-echo (T2SE). All single-slab 3D sequences and 2D-T2SE were acquired in 16 MS patients and 9 age-matched healthy controls. Lesions were scored independently by two raters and characterized anatomically. Two-tailed Bonferroni-corrected Student's t-tests were used to detect differences in lesion detection between the various sequences per anatomical area after log-transformation. In general, signal and contrast properties of the 3D sequences enabled improved detection of MS brain lesions compared to 2D-T2SE. Specifically, 3D-DIR showed the highest detection of intracortical and mixed WM-GM lesions, whereas 3D-FLAIR showed the highest total number of WM lesions. Both 3D-DIR and 3D-FLAIR showed the highest number of infratentorial lesions. 3D-T2 and 3D-MPRAGE did not improve lesion detection compared to 2D-T2SE. Multi-contrast, isotropic, single-slab 3D MRI allowed an improved detection of both GM and WM lesions compared to 2D-T2SE. A selection of single-slab 3D contrasts, for example, 3D-FLAIR and 3D-DIR, could replace 2D sequences in the radiological practice.

KW - Cortical

KW - DIR

KW - FLAIR

KW - Flow artifacts

KW - Infratentorial

UR - http://www.scopus.com/inward/record.url?scp=70450201548&partnerID=8YFLogxK

M3 - Erratum

VL - 22

SP - 33

EP - 42

JO - The Neuroradiology Journal

JF - The Neuroradiology Journal

SN - 1971-4009

IS - SUPPL. 1

ER -