Abstract

Background: Multicentric reticulohistiocytosis is a rare form of non-langerhans cell histiocytosis presenting with skin changes and erosive arthritis. Infiltration of histiocytes and multinucleated giant cells are typical histological findings and confirm the diagnosis. Case presentation: This case report describes a newly diagnosed case of multicentric reticulohistiocytosis in a healthy 26-year-old female originally from the Philippines. Eruption of papules and nodules on the hands and pain in multiple joints were the main complaints at the initial presentation. Radiographical findings of erosions in the small hand and feet joints were impressive. Initial histological findings did not match the clinical image, although later the clinical diagnosis was supported by histological findings in additional biopsies. Conclusions: Although initial histological findings did not match the clinical image, additional biopsies were valuable to confirm the diagnosis.
Original languageEnglish
Article number647
JournalBMC Research Notes
Volume11
Issue number1
DOIs
Publication statusPublished - 2018

Cite this

@article{b1dcd738f8af41c2980aa3bb00879690,
title = "Multicentric reticulohistiocytosis: A case report",
abstract = "Background: Multicentric reticulohistiocytosis is a rare form of non-langerhans cell histiocytosis presenting with skin changes and erosive arthritis. Infiltration of histiocytes and multinucleated giant cells are typical histological findings and confirm the diagnosis. Case presentation: This case report describes a newly diagnosed case of multicentric reticulohistiocytosis in a healthy 26-year-old female originally from the Philippines. Eruption of papules and nodules on the hands and pain in multiple joints were the main complaints at the initial presentation. Radiographical findings of erosions in the small hand and feet joints were impressive. Initial histological findings did not match the clinical image, although later the clinical diagnosis was supported by histological findings in additional biopsies. Conclusions: Although initial histological findings did not match the clinical image, additional biopsies were valuable to confirm the diagnosis.",
author = "Azad{\`e}h Farokhi and {van Vugt}, {Richard M.} and Rick Hoekzema and Nurmohamed, {Michael T.}",
year = "2018",
doi = "10.1186/s13104-018-3753-3",
language = "English",
volume = "11",
journal = "BMC Research Notes",
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publisher = "BioMed Central",
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}

Multicentric reticulohistiocytosis: A case report. / Farokhi, Azadèh; van Vugt, Richard M.; Hoekzema, Rick; Nurmohamed, Michael T.

In: BMC Research Notes, Vol. 11, No. 1, 647, 2018.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Multicentric reticulohistiocytosis: A case report

AU - Farokhi, Azadèh

AU - van Vugt, Richard M.

AU - Hoekzema, Rick

AU - Nurmohamed, Michael T.

PY - 2018

Y1 - 2018

N2 - Background: Multicentric reticulohistiocytosis is a rare form of non-langerhans cell histiocytosis presenting with skin changes and erosive arthritis. Infiltration of histiocytes and multinucleated giant cells are typical histological findings and confirm the diagnosis. Case presentation: This case report describes a newly diagnosed case of multicentric reticulohistiocytosis in a healthy 26-year-old female originally from the Philippines. Eruption of papules and nodules on the hands and pain in multiple joints were the main complaints at the initial presentation. Radiographical findings of erosions in the small hand and feet joints were impressive. Initial histological findings did not match the clinical image, although later the clinical diagnosis was supported by histological findings in additional biopsies. Conclusions: Although initial histological findings did not match the clinical image, additional biopsies were valuable to confirm the diagnosis.

AB - Background: Multicentric reticulohistiocytosis is a rare form of non-langerhans cell histiocytosis presenting with skin changes and erosive arthritis. Infiltration of histiocytes and multinucleated giant cells are typical histological findings and confirm the diagnosis. Case presentation: This case report describes a newly diagnosed case of multicentric reticulohistiocytosis in a healthy 26-year-old female originally from the Philippines. Eruption of papules and nodules on the hands and pain in multiple joints were the main complaints at the initial presentation. Radiographical findings of erosions in the small hand and feet joints were impressive. Initial histological findings did not match the clinical image, although later the clinical diagnosis was supported by histological findings in additional biopsies. Conclusions: Although initial histological findings did not match the clinical image, additional biopsies were valuable to confirm the diagnosis.

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