Older (> 65 years) patients who are being treated by different specialists for multiple medical problems are at increased risk of medication-related adverse effects. Unfortunately, little is known about the efficacy and safety of many medicines in these vulnerable patients. General practitioners can limit the risk of adverse effects by following the recommendations of the 'Polypharmacy for the Elderly' guideline and by using the START (Screening Tool to Alert doctors to Right Treatment) and STOPP (Screening Tool of Older Person's Prescriptions) criteria of the guideline. In addition, GPs can work with pharmacists to provide integrated pharmaceutical care by system atically evaluating the medicines prescribed using the stepwise approach of the STRIP (Systematic Tool to Reduce Inappropriate Prescribing). However, a number of preconditions for a good evaluation of medications have still to be met.